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Odontoestomatología

versão impressa ISSN 0797-0374versão On-line ISSN 1688-9339

Odontoestomatología vol.25 no.42 Montevideo  2023  Epub 01-Dez-2023

https://doi.org/10.22592/ode2023n42e419 

Case report

Proliferative verrucous leukoplakia mimicking oral lichen planus: case report and literature review

Leucoplasia verrucosa proliferativa simulando líquen plano oral: relato de caso e revisão da literatura

1 São Paulo State University, Institute of Science and Technology, Department of Biosciences and Oral Diagnosis, São José dos Campos, São Paulo, Brazil. e-mail: mateus.dutra@unesp.br

2 São Paulo State University, Institute of Science and Technology, Department of Biosciences and Oral Diagnosis, São José dos Campos, São Paulo, Brazil.

3 University of Chile, Faculty of Dentistry, Department of Pathology and Oral Medicine, Santiago, Chile.

4 São Paulo State University, Institute of Science and Technology, Department of Biosciences and Oral Diagnosis, São José dos Campos, São Paulo, Brazil.

5 São Paulo State University, Institute of Science and Technology, Department of Biosciences and Oral Diagnosis, São José dos Campos, São Paulo, Brazil.


Abstract

This report presents the clinical, microscopic and immunohistochemical aspects of a case of proliferative verrucous leukoplakia (PVL) mimicking oral lichen planus (OLP) in a 66-year-old woman. We also review the literature reporting cases of PVL mimicking OLP, where we found a higher prevalence in women who do not consume tobacco or alcohol. The initial manifestation of lichenoid areas was around the age of 59, with the diagnosis of PVL being established on average 6 years later, while malignant transformation occurred in 8 of the 22 cases at an average of 3.7 years after the final diagnosis of PVL. We emphasize the need for a close follow-up of any patient presenting white lesions of the oral mucosa. Lesions that are clinically and microscopically compatible with lichenoid reactions or OLP must be investigated and differentiated from PVL, which has a worse prognosis.

Keywords: Oral leukoplakia; Oral lichen planus; CD20; Syndecan-1; B- Lymphocytes

Resumo

Este relato apresenta os aspectos clínicos, microscópicos e imuno-histoquímicos de um caso de leucoplasia verrucosa proliferativa (LPV) mimetizando líquen plano oral (LPO) em uma paciente do sexo feminino de 66 anos. Também revisamos a literatura relatando casos de LPV mimetizando LPO, onde encontramos maior prevalência em mulheres que não consomem tabaco ou álcool, com manifestação inicial de áreas liquenoides por volta dos 59 anos, sendo estabelecido o diagnóstico de LPV em média 6 anos depois, enquanto a transformação maligna ocorreu em 8 dos 22 casos em média 3,7 anos após o diagnóstico final de LPV. Ressaltamos a necessidade de acompanhamento rigoroso de qualquer paciente que apresente lesões brancas da mucosa oral, devendo ser investigadas lesões clinicamente e microscopicamente compatíveis com reações liquenóides ou LPO e diferenciadas da LPV, que tem pior prognóstico

Palavras-chave: Leucoplasia oral; Líquen Plano Oral; CD20; Syndecan-1; Linfócitos-B

Resumen

Este reporte presenta los aspectos clínicos, microscópicos e inmunohistoquímicos de un caso de leucoplasia verrugosa proliferativa (LVP) simulando liquen plano oral (LPO) en una paciente de 66 años. También revisamos la literatura reportando casos de LVP simulando LPO, donde encontramos una mayor prevalencia en mujeres que no consumen tabaco ni alcohol, con una manifestación inicial de áreas liquenoides alrededor de los 59 años, estableciéndose el diagnóstico de LVP en promedio 6 años después, mientras que la transformación maligna ocurrió en 8 de los 22 casos en un promedio de 3,7 años después del diagnóstico final de LVP. Resaltamos la necesidad de un seguimiento estrecho de todo paciente que presente lesiones blanquecinas de la mucosa oral, que las lesiones clínica y microscópicamente compatibles con reacciones liquenoides o LPO deben ser investigadas y diferenciadas de la LVP, que tienen peor pronóstico.

Palabras clave: Leucoplasia oral; Liquen plano oral; CD20; Syndecan-1; Linfócitos B.

INTRODUCTION

Proliferative verrucous leukoplakia (PVL) is a non-homogeneous form of oral leukoplakia (OL). It is characterized by multifocal, slow-growing white plaques that are refractory to therapeutic procedures and have high rates of recurrence and malignancy (1-3) ranging from 70 to 100% of all cases (4-7).

In the early stages, it may present clinicopathological aspects similar to oral lichen planus (OLP) (3,8) which is an immunologically mediated mucocutaneous disease with a malignant transformation rate of approximately 1.4% (9). Clinically, both can present as multifocal white plaques or striae, bilaterally affecting the buccal mucosa and the alveolar ridge, attached gingiva, tongue, and lips (10,11). The verrucous conformation formed by surface keratin is an important clinical finding that contributes to the distinction between PVL and OLP (12-14). Both affect predominantly women in their 60s who do not use tobacco or alcohol (15,16). Given the overlapping clinical and epidemiological characteristics of PVL and OLP, relying solely on these factors for diagnosis is insufficient. Therefore, microscopic evaluation becomes imperative (11,17).

Microscopic findings of OLP can closely resemble those observed in PVL, but PVL can present dysplasia ranging from mild to severe, or, in some instances, reveal a squamous cell carcinoma (5). However, PVL lacks uniformity, thus tissues from the same patient and different anatomical locations may differ from each other (12,18). Areas affected by PVL might exhibit a banded lymphocytic infiltrate, and by combining the clinical and microscopic features, a misdiagnosis of OLP may be established, especially in early cases where there is no epithelial dysplasia (13,18-20).

This report presents the clinical and microscopic aspects observed in a case of PVL mimicking OLP and discusses the protein expression of CD20 and CD138 for the identification of B cells in the subepithelial inflammatory infiltrate of the lesions. The literature on reported cases of PVL mimicking OLP is also reviewed, in order to outline a clinical and epidemiological profile of these patients, as well as the average time of change from diagnosis to PVL and the average time of malignant transformation.

CASE REPORT

A 66-year-old Latin-American woman presented to the Stomatology Clinic of Institute of Science and Technology, São Paulo State University (ICT-UNESP) reporting white patches in her mouth and a burning sensation. During the anamnesis, she denied addictions such as smoking or alcohol consumption. She also reported being hypertensive and the daily use of Losartan® 25 mg orally. On general physical examination, purplish patches were noted in the tibiofemoral joint region. On intraoral physical examination, white striae were bilaterally observed on the buccal mucosa (Figures 1A and B).

Figure 1: Photos of initial clinical manifestations, white striae on the buccal mucosa. A. Right buccal mucosa. B. Left buccal mucosa. 

Given the clinical suspicion of OLP and lichenoid reaction (LR), an incisional biopsy was performed on the right buccal mucosa. Microscopic examination revealed a mucosal fragment covered by stratified squamous epithelium with hyperkeratosis, sawtooth-shaped epithelial ridges, exocytosis towards the lower epithelial portion, and a band of inflammatory lymphocytic infiltrate in the lamina propria beneath the epithelium (Figure 2A).

Figure 2:  Microphotographs of biopsies 

To rule out the clinical hypothesis of LR to Losartan®, the physician was asked to replace the antihypertensive drug, which improved the clinical condition, and the diagnosis of OLP was established. However, due to the COVID-19 pandemic, the patient returned for a follow-up visit three years after the initial diagnosis of OLP. White striae were noticed on the lower lip and tongue edge, multiple white plaques with a leathery surface that had a 5 mm diameter maximum located on the buccal floor, attached gingiva, and alveolar ridge of the mandible on the left and right sides that extended to the buccal mucosa, non-homogeneous and with areas of verrucous appearance (Figures 3A-D).

Figure 3 Photos of clinical manifestations before the second biopsy revealing white striae. A. Lower lip. B. Tongue border. Non-homogeneous and verrucous appearance of white plaque C. Buccal mucosa. D. Lower right alveolar ridge. 

Incisional biopsies were performed on the right buccal mucosa and lower anterior gingiva, under the hypothesis of PVL. Microscopically, fragments of the buccal mucosa exhibited ortho-keratinized stratified squamous epithelium, with areas of evident granular layer, atrophy, spongiosis, and lymphocytic exocytosis. In the lamina propria, a band of inflammatory lymphocytic infiltrate was observed in the subepithelial region (Figure 2. D), and the histopathological diagnosis was compatible with OLP. Examination of the lower anterior attached gingiva showed keratinized stratified squamous epithelium, with an evident granular layer and abrupt change in the keratinization pattern, an area of intense atrophy, rectification of the basal layer and some mitoses not restricted to this layer. The lamina propria showed moderate diffuse chronic inflammatory infiltrate, and the histopathological diagnosis was hyperkeratosis with moderate epithelial dysplasia (Figure 2G). Based on the clinical features of the lesions and the histopathological characteristics, the final diagnosis of PVL was made. The patient is currently under follow-up.

Immunohistochemistry reactions were performed for CD20 and CD138 proteins (Table 1). CD20 and CD138 were diffusely labeled on the inflammatory cells of the connective tissue of all biopsies performed. Epithelial intercellular junctions were positive for CD138 (Figures 2. B, C, E, F, H, and I).

Table 1: Antibodies, clones, sources, nature of antibodies, and dilution tested 

Antibody CD20 CD138
Type Monoclonal Monoclonal
Clone L26 ZR251
Company Dako, Denmark Zeta Corporation, USA
Nature of antibodies Mouse Rabbit
Dilution tested 1:200 1:100

LITERATURE REVIEW

The Pubmed database was used to search for reported cases of PVL with initial presentation as LR or OLP, until April 2023. The MesH terms used for the search were “proliferative verrucous leukoplakia” AND “oral lichen planus” and “proliferative verrucous leukoplakia” AND “lichenoid”. The search yielded 59 and 22 results, respectively. Of these, only case and series reports were studied, resulting in 5 articles. As an inclusion criterion, the articles should be published in English and the patients should have the final diagnosis of PVL but preceded by a diagnosis or clinical appearance of LR or OLP. Of the 5 articles only 3 met all inclusion criteria and were included in the review. Information collected was: gender, age at initial diagnosis, tobacco and alcohol use, initial diagnosis, the mean time interval from diagnosis of LR/OLP to PVL, a clinical or histopathological final diagnosis of PVL, histological findings, information on verrucous areas or not, whether there was malignant transformation, and how long after the diagnosis of PVL. The epidemiological data of the cases (n=22) is summarized in Table 2. The prevalence was reported in women (n=19), who at the time of diagnosis did not consume tobacco (n=22) or alcohol (n=12), with an initial manifestation of lichenoid areas around 59 years of median age.

Table 2: Data extracted from the cases included in the literature review. 

Lopes et al., 2015 Garcia-Pola et al., 2016 McCarthy et al., 2022
Number of cases 1 (100%) 14 (100%) 7 (100%)
Female 1 (100%) 11 (78,57%) 7 (100%)
Non/ex-smoker 1/0 (100/0%) 11/3 (78,58/21,42%) 5/2 (71,42/28,57%)
Alcohol consumption 0 (0%) 3 (21,42%) NR
Average age at initial diagnosis (years) 64 56 57
Initial diagnosis clinical clinical/histological clinical/histological
PVL diagnosis clinical/histological clinical/histological clinical/histological
Mean time interval of diagnosis from OLP/LR to PVL (years) NR 4 8
Histological findings mild/moderate epithelial dysplasia hyperkeratosis and verrucous hyperplasia verrucous hyperplasia and severe epithelial dysplasia
Verrucous areas 0 14 (100%) 7 (100%)
Oral cancer diagnosis - number of cases 1 (100%) 4 (28,57%) 3 (42,85%)
Oral cancer diagnosis - how long after PVL diagnosis 15 months average of 9 years average of 11 months

NR- non reported.

In 21 cases, the initial diagnosis of LR or OLP was confirmed by biopsy, and the average time of diagnosis change from LR or OLP to PVL was 6 years. The diagnosis of PVL was made clinically and histologically and only one case did not have a verrucous aspect. 8 of 22 cases progressed to squamous cell carcinoma, with a median of 3.7 years after the initial diagnosis of PVL (Table 2).

DISCUSSION

This study reports the case of a patient who initially presented clinical and microscopic characteristics similar to LR and OLP, as she presented white striae on the buccal mucosa and was using antihypertensive medication (21,22). The antihypertensive medication was replaced by the physician and there was no change in her lesions, ruling out the diagnosis of LR (21). After 4 years of follow-up, there was a change in the clinical scenario and the hypothesis of PVL was formulated, since it has an epidemiology similar to that described in OLP (15,16). PVL is characterized by multifocal white plaques, which may or may not have a verrucous surface (8,15). Plus, in the early stages, it may present a striated pattern as in OLP (23).

PVL and OLP also share similar microscopic characteristics, as PVL can present a banded lymphocytic infiltrate, favoring a misdiagnosis of LR or OLP(5,10,11,13,17,19,24-26). What contributed to the differentiation between LR, OLP, and PVL is the presence of epithelial dysplasia and a papillary/verrucous surface that are absent in LR and OLP. However, these findings may not be present in early cases of PVL (14,21,27,28). The incisional biopsies of the buccal mucosa in this case met the microscopic criteria for OLP. However, one of the fragments from the second biopsy revealed the presence of epithelial dysplasia and an abrupt change in the keratinization pattern, favoring the diagnosis of PVL.

Although there are no biomarkers to differentiate between PVL and OLP, some proteins, such as CD20 and CD138, can contribute to the prognosis. CD138 is useful to reveal the cohesion between epithelial cells: the greater the degree of dysplasia, the lower the CD138 staining at epithelial intercellular junctions (24). In this report, there was immunopositivity for CD138 among epithelial cells, as there was moderate dysplasia. Its hypoexpression indicates dysregulation of cell adhesion, increasing the spread of neoplasm cells due to lower adherence and resistance to apoptosis, associated with a worse prognosis (30-32). CD138 expression was also noted in the inflammatory cells present in the lamina propria, revealing the presence of B lymphocytes or plasma cells that are not normally seen in OLP (33), contrasting with the findings of Mahdavi et al. (34), who reported B cells in the inflammatory infiltrate of OLP through protein expression of CD20. In this report, CD20 expression was observed in the subepithelial inflammatory infiltrate. Characterization of the cells present in the inflammatory infiltrate, using CD20 and CD138 antibodies, was not useful to distinguish OLP from PVL, but analysis of CD138 expression is valid for assessing the cohesion between epithelial cells.

The question as to whether OLP turned into PVL or PVL initially presented with characteristics of OLP has been discussed. Lopes et al. (13), reported a case of a woman who presented white striae with atrophic areas in the buccal mucosa bilaterally with the hypothesis of LR excluded after metal restorations were replaced without resolution. Incisional biopsies revealed hyperkeratosis and acanthosis with mild epithelial dysplasia, suggesting the diagnosis of PVL, similar to the present report. However, after 15 months another biopsy revealed the diagnosis of squamous cell carcinoma. Our patient has been followed up for 48 months, with no signs of malignant transformation.

In our report, the transition time from OLP to PVL was similar to Garcia-Pola et al.’s (26) findings, since they reported that 4 years was the average time for the development of multifocal, plaque-like verrucous lesions. In some cases, there was also malignant transformation during the follow-up period(11,26,35).

Malignant transformation of OLP is a subject of great discussion and it occurs in 1.4% of cases (9). Thus, the case series described above could be cases of PVL misdiagnosed as OLP, since PVL may initially present as white spots with lichenoid characteristics, which later evolves into the classic clinical features. It should be included in the differential diagnosis of lesions with lichenoid changes, both clinically and microscopically (27,35).

There is no consensus on whether PVL evolves from OLP, whether its initial presentation mimics OLP, or whether the two lesions can occur simultaneously in the same patient. That being said, the last hypothesis is not supported by any reports published in the current English literature. The hypothesis that PVL mimics OLP is the most plausible for this report, since the biopsy performed during the follow-up period showed clinical and microscopic characteristics similar to OLP and the other to PVL.

CONCLUSIONS

Lesions that appear whitish and are consistent with RL or LPO must be investigated and distinguished from LVP. It's crucial to closely monitor patients diagnosed with whitish lesions, as clinical changes may manifest, and consequently, the diagnosis, which is essential in cases of LVP given its unfavorable prognosis and high rates of malignant transformation.

​​Additionally, we conclude that the reported cases of LVP mimicking OLP were more prevalent among women who were non-smokers and non-alcohol consumers. The onset of lichenoid areas typically occurs around the age of 59, and the diagnosis of LVP is established, on average, six years later. The malignant transformation occurred in 8 out of the 22 reported cases, with an average of 3.7 years following the final diagnosis of LVP.

References

1. Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles MÁ, Kerr AR, et al. Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer. Oral Dis. 2021 Nov;27(8):1862-1880. [ Links ]

2. Hansen LS, Olson JA, Silverman S Jr. Proliferative verrucous leukoplakia. A long-term study of thirty patients. Oral Surg Oral Med Oral Pathol. 1985;60:285-98. [ Links ]

3. Warnakulasuriya S. Clinical features and presentation of oral potentially malignant disorders. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125:582-90. [ Links ]

4. Pentenero M, Meleti M, Vescovi P, Gandolfo S. Oral proliferative verrucous leucoplakia: are there particular features for such an ambiguous entity? A systematic review. Br J Dermatol. 2014;170:1039-47. [ Links ]

5. Villa A, Menon RS, Kerr AR, De Abreu Alves F, Guollo A, Ojeda D, et al. Proliferative leukoplakia: Proposed new clinical diagnostic criteria. Oral Dis. 2018;24:749-60. [ Links ]

6. Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, et al. Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype. Head Neck. 2020;42:539-555. [ Links ]

7. Alkan U, Bachar G, Nachalon Y, Zlotogorsky A, Levin EG, Kaplan I. Proliferative verrucous leukoplakia: a clinicopathological comparative study. Int J Oral Maxillofac Surg. 2022;51:1027-1033. [ Links ]

8. Aguirre-Urizar JM. Proliferative multifocal leukoplakia better name that proliferative verrucous leukoplakia. World J Surg Oncol. 2011;9:122. [ Links ]

9. González-Moles MÁ, Ramos-García P, Warnakulasuriya S. An appraisal of highest quality studies reporting malignant transformation of oral lichen planus based on a systematic review. Oral Dis. 2021;27:1908-1918. [ Links ]

10. van der Meij EH, van der Waal I. Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications. J Oral Pathol Med. 2003;32:507-12. [ Links ]

11. McCarthy C, Kazmi A, Austin T, Ho MW, Chengot P, Rajlawt BP, et al. The development of Proliferative Verrucous Leukoplakia on a background of oral lichen planus: A case series. Adv in Oral and Maxil Surg. 2022;6:100263. [ Links ]

12. Gillenwater AM, Vigneswaran N, Fatani H, Saintigny P, El-Naggar AK. Proliferative verrucous leukoplakia (PVL): a review of an elusive pathologic entity! Adv Anat Pathol. 2013;20:416-23. [ Links ]

13. Lopes MA, Feio P, Santos-Silva AR, Vargas PA. Proliferative verrucous leukoplakia may initially mimic lichenoid reactions. World J Clin Cases. 2015;3:861-863. [ Links ]

14. Gilligan G, Garola F, Piemonte E, Leonardi N, Panico R, Warnakulasuriya S. Lichenoid proliferative leukoplakia, lichenoid lesions with evolution to proliferative leukoplakia or a continuum of the same precancerous condition? A revised hypothesis. J Oral Pathol Med. 2021;50:129-135. [ Links ]

15. Carrozzo M, Porter S, Mercadante V, Fedele S. Oral lichen planus: A disease or a spectrum of tissue reactions? Types, causes, diagnostic algorhythms, prognosis, management strategies. Periodontol. 2019;80:105-125. [ Links ]

16. González-Moles MÁ, Warnakulasuriya S, González-Ruiz I, González-Ruiz L, Ayén Á, Lenouvel D, et al. Worldwide prevalence of oral lichen planus: A systematic review and meta-analysis. Oral Dis. 2021;27:813-828. [ Links ]

17. Cerero-Lapiedra R, Baladé-Martínez D, Moreno-López LA, Esparza-Gómez G, Bagán JV. Proliferative verrucous leukoplakia: a proposal for diagnostic criteria. Med Oral Patol Oral Cir Bucal. 2010;15:e839-45. [ Links ]

18. Ranganathan K, Kavitha L. Oral epithelial dysplasia: Classifications and clinical relevance in risk assessment of oral potentially malignant disorders. J Oral Maxillofac Pathol. 2019;23:19-27. [ Links ]

19. Morton TH, Cabay RJ, Epstein JB. Proliferative verrucous leukoplakia and its progression to oral carcinoma: report of three cases. J Oral Pathol Med. 2007;36:315-8. [ Links ]

20. Goodson ML, Sloan P, Robinson CM, Cocks K, Thomson PJ. Oral precursor lesions and malignant transformation--who, where, what, and when? Br J Oral Maxillofac Surg. 2015;53:831-5. [ Links ]

21. van der Waal I. Oral lichen planus and oral lichenoid lesions; a critical appraisal with emphasis on the diagnostic aspects. Med Oral Patol Oral Cir Bucal. 2009 Jul 1;14:E310-4. [ Links ]

22. Serrano-Sánchez P, Bagán JV, Jiménez-Soriano, Sarrión G. Drug-induced oral lichenoid reactions. A literature review. J Clin Exp Dent. 2010;2:e71-5. [ Links ]

23. Barba-Montero C, Lorenzo-Pouso AI, Gándara-Vila P, Blanco-Carrión A, Marichalar-Mendía X, García-García A, et al. Lichenoid areas may arise in early stages of proliferative verrucous leukoplakia: A long-term study of 34 patients. J Oral Pathol Med. 2022;51:573-581. [ Links ]

24. Müller S. Oral manifestations of dermatologic disease: a focus on lichenoid lesions. Head Neck Pathol. 2011;5:36-40. [ Links ]

25. Abadie WM, Partington EJ, Fowler CB, Schmalbach CE. Optimal Management of Proliferative Verrucous Leukoplakia: A Systematic Review of the Literature. Otolaryngol Head Neck Surg. 2015;153:504-11. [ Links ]

26. Garcia-Pola MJ, Llorente-Pendás S, González-Garcia M, García-Martín JM. The development of proliferative verrucous leukoplakia in oral lichen planus. A preliminary study. Med Oral Patol Oral Cir Bucal. 2016;21:e328-34. [ Links ]

27. Müller S. Oral epithelial dysplasia, atypical verrucous lesions and oral potentially malignant disorders: focus on histopathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125:591-602. [ Links ]

28. Davidova LA, Fitzpatrick SG, Bhattacharyya I, Cohen DM, Islam MN. Lichenoid Characteristics in Premalignant Verrucous Lesions and Verrucous Carcinoma of the Oral Cavity. Head Neck Pathol. 2019;13:573-9. [ Links ]

30. Wang H, Leavitt L, Ramaswamy R, Rapraeger AC. Interaction of syndecan and alpha6beta4 integrin cytoplasmic domains: regulation of ErbB2-mediated integrin activation. J Biol Chem. 2010;285:13569-79. [ Links ]

31. Anttonen A, Kajanti M, Heikkilä P, Jalkanen M, Joensuu H. Syndecan-1 expression has prognostic significance in head and neck carcinoma. Br J Cancer. 1999;79:558-64. [ Links ]

32. Gharbaran R. Advances in the molecular functions of syndecan-1 (SDC1/CD138) in the pathogenesis of malignancies. Crit Rev Oncol Hematol. 2015;94:1-17. [ Links ]

33. Gupta S, Jawanda MK. Oral Lichen Planus: An Update on Etiology, Pathogenesis, Clinical Presentation, Diagnosis and Management. Indian J Dermatol. 2015;60:222-9. [ Links ]

34. Mahdavi N, Aminishakib P, Soltani N. Presence of B Cells and Plasma Cells in Oral Lichen Planus. J Dent. 2020;21:209-214. [ Links ]

35. McParland H, Warnakulasuriya S. Lichenoid morphology could be an early feature of oral proliferative verrucous leukoplakia. J Oral Pathol Med. 2021;50:229-235. [ Links ]

Nota:Conflict of Interest StatementAuthorship contribution noteAcceptance note:

Received: July 20, 2023; Accepted: November 12, 2023

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