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vol.37 número 3Traumatismo cráneo-encefálico (TCE) y anticoagulación: Aspectos esenciales. índice de autoresíndice de assuntospesquisa de artigos
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Archivos de Medicina Interna

versão impressa ISSN 0250-3816versão On-line ISSN 1688-423X


HACKEMBRUCH, H. Jochen; PERNA, Abayubá; GAYE, Andrés  e  CAAMANO, José. Lambert Syndrome - Eaton: Clinical and neurophysiological characteristics. Arch. Med Int [online]. 2015, vol.37, n. 3, pp.163-166. ISSN 0250-3816.

Abstract:   Lambert Eaton myasthenic syndrome (LEMS) is an uncommon neuromuscular joint disease, usually infra diagnosed, with characteristic but nonspecific clinical symptoms but very typical neurophysiological findings. In most cases it is a paraneoplastic syndrome although idiopathic  forms also exist. We describe the case of a patient with typical clinical presentation and neurophysiological findings that allowed the diagnosis. The initial screening for hidden malignancy was negative, but the follow up is essential to rule it out given its strong association. The evolution was satisfactory with symptomatic treatment. We discuss the pathophysiology of the disorder, establishing as fundamental fact, the presence of antibodies against presynaptic voltage-dependent calcium channels, which is essential to understand the symptomatic treatment. We review the features that are associated with increased risk of hidden malignancy and propose a follow-up strategy to throw it off early

Palavras-chave : Eaton Lambert; Myasthenic síndrome; Paraneoplastic syndrome.

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