Resumo

VICENTA PAPARELLA, Cecilia; PAVESI, Adriana Beatriz; FELDMAN, Rodolfo Néstor  e  BOUVET, Beatriz Reina. Importance of the assessment of oxidative stress in human semen. Arch. Med Int [online]. 2015, vol.37, n. 1, pp.7-14. ISSN 0250-3816.

Data from Medline, Science Direct, Endocrine Society and organisms of information of Argentina Society of Andrology were used to study and interpret the effect of oxidative stress (OS) in the reproductive process. The living things use the oxygen for energy they release reactive oxygen species (ROS). There andrology situations enviromental factors, chemical agents that increase of proinflammatory cytokines, OS generated by altering the regulation of spermatogenesis process. The spermatozoids due to high concentration of polyunsaturated fatty acids (PFA) in its membrane are sensitive to the oxidative damage induced for ROS and it also contain low levels of antioxidant enzymes for their limited cytoplasm. OS induced peroxidative damage in sperm membrane and DNA fragmentation in the nuclear and mitochondrial genomes. The modified sperm stress test (MOST) estimates sperm resistance to lipoperoxidation. The ROS increased in men with reproductive disorders and its correlation with seminal alterations reveal the importance of the evaluation of OS in the study of man consulting for infertility.

Palavras-chave : Oxidative stress; Reproductive process; Reactive oxygen species; Spermatozoid; Men infertility.