Resumo

GIACHETTO 1, Gustavo et al. Uso de vancomicina en servicios de internación pediátrica del Centro Hospitalario Pereira Rossell. Arch. Pediatr. Urug. [online]. 2006, vol.77, n.2, pp.118-124. ISSN 1688-1249.

Summary Introduction: between 2002- 2004 vancomycin use in the CHPR triplicated due to an increased prescription at the pediatric hospitalization services. It is necessary to establish an alertness program in order to avoid antimicrobial resistance and unnecessary cost raise. Objective: to analyze vancomycin use in the pediatric hospitalisation services of the CHPR to identify resistance risk factors. Methods: an observational study took place between July and August 2005; hospitalized children who were being treated with vancomycin were included. Prescription characteristics were analysed (indication, dosage, plasmatic monitorization, withdrawal reasons, microbiologic study) using “Antibiotic therapy guidelines of Pediatric Hospital CHPR” and “Recommendations for Preventing the Spread of Vancomycin Resistance” from the Centre for Disease Control and Prevention of United States (CDC) as a gold standard. Results: 31 of 434 children included in the study received vancomycin. Vancomycin use was more common in neonatal (n=9) and children (n=6) intensive care units and hematoncology (n=6). Prophylactic use was not observed. Therapeutic indications were adjusted to the recommendation in 12 children. Vancomycin resistance risk factors identified were: prolonged empirical use (n=20), prolonged treatment (n=6), its use although alternatives (n=8), inadecuate dosage (n=5). Conclusions: during the studied period several problems related to vancomycin use were identified. It is necessary to create corrective strategies to improve its use

Palavras-chave :  VANCOMYCIN; VANCOMYCIN RESISTANCE;   RISK FACTORS.

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