Resumo

DANIELA, Lens et al. Trombofilia y pérdida recurrente de embarazo. Rev. Méd. Urug. [online]. 2004, vol.20, n.2, pp.106-113. ISSN 1688-0390.

Summary Hematologists and obstetricians have been studying the incidence of prothrombotic factors in recurrent pregnancy loss. The progressive identification of different thrombophilic pathologies is a challenge for diagnosis new causes of recurrent pregnancy loss. The study included 115 women with recurrent pregnancy loss with no hormonal, anatomic, infectious and genetic causes. Thrombophilic causes were determined and compared with a control group. Among prothrombotic factors, the prevalence of antiphospholipid /anticoagulante lúpico antibodies was higher (p<0.0001 OR=8.85 IC95% 3.8-20.8), lipoproteine (a) (p<0.0001 OR=6.05 IC95% 2.5-14.3), factor V Leiden (p<0.0005 OR=5 IC95% 1.5-21), factor II G20210A (p<0.0005 OR=4 IC95% 1.4-11.5) and MTHFR C677T variant homocigota (p<0.0002 OR=2.4 IC95% 1.1-5.1). Association of two or more thrombotic risk factors was seen in 65% women, therefore thromophilic analysis must be complete.

Palavras-chave : TROMBOFILIA; ABORTO HABITUAL.

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