Resumo

PEDREIRA, Walter; ANZALONE, Leonardo; ALVEZ, Marcelo  e  CAFFERATTA, Alina. Fosfomicina trometamol. Una opción terapéutica válida en infecciones urinarias bajas . Rev. Méd. Urug. [online]. 2003, vol.19, n.2, pp.107-116. ISSN 1688-0390.

Summary Low urinary infection is a frequent pathology in women with good prognosis but high morbility. Fosfomycin is a phosphoric acid derivative able to alter bacterial wall. Its activity comprises most of the uropathogenic agents with a 1% resistance in Escherichia coli, the most important uropathogen. Trometamol facilitates absorbtion of fosfomycin obtaining urinary concentration with therapeutic range lasting for three days after a 3 g dose. Objectives: to determine the clinical/microbiological efficacy and safety of a single-3 g dose of fosfomycin trometamol (Fosfurol) in women with low non-complicated urinary infection. Methods: a multicenter, randomized, non-comparative prospective study was undertaken. Fifty-four patients of public health centers and one private clinic presented symptoms of low urinary infection without taking antibiotics the previous 15 days. Urine was collected using reactives for abnormal elements and cultures for bactriuria. Patients with urinary infection received a single-3 g dose of fosfomycin trometamol. Strains were identified and sensitivity was studied. A clinical and microbiological follow up was done at the first and third week. Results: germens were isolated as follow: 41 Escherichia coli, 4 Staphylococcus saprophyticus, 4 Proteus sp, 1 Enterococcus sp, 2 Klebsiella sp, 1 Streptococcus agalactiae and 1 Enterobacter sp. Only 3 strains of Staphylococcus saprophyticus and one strain of Klebsiella sp presented resistance in vitro. Conclusions: low fosfomycin resistance in vitro altogether with high clinical-microbiological efficacy and tolerance to this antimicrobian indicate that it is a useful therapeutic in treating non-complicated urinary infections in women.

Palavras-chave : INFECCIONES URINARIAS [quimioterapia]; FOSFOMICINA [uso terapéutico]; TROMETAMOL [uso terapéutico].

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