<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2393-6797</journal-id>
<journal-title><![CDATA[Revista Uruguaya de Medicina Interna ]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Urug. Med. Int.]]></abbrev-journal-title>
<issn>2393-6797</issn>
<publisher>
<publisher-name><![CDATA[Sociedad de Medicina Interna del Uruguay]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2393-67972026000101403</article-id>
<article-id pub-id-type="doi">10.26445/11.01.5</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Hipoacusia sensorioneural autoinmune: ¿cuándo plantear y cómo tratar?]]></article-title>
<article-title xml:lang="en"><![CDATA[Autoimmune sensorineural hearing loss: when to consider and how to treat?]]></article-title>
<article-title xml:lang="pt"><![CDATA[Perda auditiva neurossensorial autoimune: quando considerar e como tratar?]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sanguinetti]]></surname>
<given-names><![CDATA[Maximiliano]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cairoli]]></surname>
<given-names><![CDATA[Ernesto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[D´Albora]]></surname>
<given-names><![CDATA[Ricardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mónaco]]></surname>
<given-names><![CDATA[María Julia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Asistencial Médica (Institución Asistencia Médica Colectiva - IAMC) Departamento de Medicina Interna ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Maldonado</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Administración de Servicios de Salud del Estado (ASSE) Hospital Pasteur Departamento de emergencia]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de la República Facultad de Medicina Unidad Académica de Otorrinolaringología]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad del Museo Social Argentino  ]]></institution>
<addr-line><![CDATA[Buenos Aires ]]></addr-line>
<country>Argentina</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2026</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2026</year>
</pub-date>
<volume>11</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S2393-67972026000101403&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S2393-67972026000101403&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S2393-67972026000101403&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La hipoacusia sensorioneural (HSN) autoinmune es una causa poco frecuente dentro de las HSN súbitas y rápidamente progresivas del adulto, que puede presentarse como una manifestación clínica aislada de enfermedad autoinmune, o bien formando parte de una enfermedad autoinmune o inflamatoria sistémica subyacente. No existen marcadores inmunológicos o inflamatorios específicos, debiendo plantear su diagnóstico cuando se instala a forma de HSN rápidamente progresiva, siendo esto una bandera roja para sospechar la existencia de una enfermedad inmunomediada del oído interno. Una vez hecho el diagnóstico de HSN independientemente de la etiología planteada, debe iniciarse tratamiento con glucocorticoides como primera línea, debiendo en casos de HSN autoinmune continuar el mismo con inmunosupresores, no existiendo una recomendación específica, pudiendo el metotrexate ser la opción inicial.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Autoimmune sensorineural hearing loss (SNHL) is a rare cause of sudden and rapidly progressive SNHL in adults. It can present as an isolated clinical manifestation of autoimmune disease or as part of an underlying systemic autoimmune or inflammatory disease. There are no specific immunological or inflammatory markers, and its diagnosis should be considered when it presents as rapidly progressive SNHL, which is a red flag for suspecting an immune-mediated disease of the inner ear. Once SNHL is diagnosed, regardless of the etiology, treatment should begin with glucocorticoids as first-line therapy. In cases of autoimmune SNHL, treatment should be continued with immunosuppressants. There is no specific recommendation for immunosuppressants, but methotrexate may be the initial option.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo A perda auditiva neurossensorial autoimune (PANS) é uma causa rara de PANS súbita e rapidamente progressiva em adultos. Pode se apresentar como uma manifestação clínica isolada de doença autoimune ou como parte de uma doença autoimune ou inflamatória sistêmica subjacente. Não existem marcadores imunológicos ou inflamatórios específicos, e seu diagnóstico deve ser considerado quando se apresenta como PANS rapidamente progressiva, o que é um sinal de alerta para suspeitar de uma doença imunomediada do ouvido interno. Uma vez diagnosticada a PANS, independentemente da etiologia, o tratamento deve começar com glicocorticoides como terapia de primeira linha. Em casos de PANS autoimune, o tratamento deve ser continuado com imunossupressores. Não há recomendação específica para imunossupressores, mas o metotrexato pode ser a opção inicial.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[hipoacusia sensorioneural]]></kwd>
<kwd lng="es"><![CDATA[hipoacusia sensorio neural autoinmune]]></kwd>
<kwd lng="es"><![CDATA[enfermedad autoinmune del oído interno]]></kwd>
<kwd lng="es"><![CDATA[prednisona]]></kwd>
<kwd lng="es"><![CDATA[inmunosupresores]]></kwd>
<kwd lng="es"><![CDATA[metotrexate]]></kwd>
<kwd lng="en"><![CDATA[sensorineural hearing loss]]></kwd>
<kwd lng="en"><![CDATA[autoimmune sensorineural hearing loss]]></kwd>
<kwd lng="en"><![CDATA[autoimmune inner ear disease]]></kwd>
<kwd lng="en"><![CDATA[prednisone]]></kwd>
<kwd lng="en"><![CDATA[immunosuppressants]]></kwd>
<kwd lng="en"><![CDATA[methotrexate]]></kwd>
<kwd lng="pt"><![CDATA[perda auditiva neurossensorial]]></kwd>
<kwd lng="pt"><![CDATA[perda auditiva neurossensorial autoimune]]></kwd>
<kwd lng="pt"><![CDATA[doença autoimune do ouvido interno]]></kwd>
<kwd lng="pt"><![CDATA[prednisona]]></kwd>
<kwd lng="pt"><![CDATA[imunossupressores]]></kwd>
<kwd lng="pt"><![CDATA[metotrexato]]></kwd>
</kwd-group>
</article-meta>
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