<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2393-6797</journal-id>
<journal-title><![CDATA[Revista Uruguaya de Medicina Interna ]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Urug. Med. Int.]]></abbrev-journal-title>
<issn>2393-6797</issn>
<publisher>
<publisher-name><![CDATA[Sociedad de Medicina Interna del Uruguay]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2393-67972020000100041</article-id>
<article-id pub-id-type="doi">10.26445/05.01.5</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Hemofilia adquirida. Presentación de caso clínico y revisión de la bibliografía.]]></article-title>
<article-title xml:lang="en"><![CDATA[Acquired hemophilia. Presentation of clinical case and review of the bibliography.]]></article-title>
<article-title xml:lang="pt"><![CDATA[Hemofilia adquirida. Apresentação de caso clínico e revisão da bibliografia.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vuan]]></surname>
<given-names><![CDATA[María Fiorella]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morin]]></surname>
<given-names><![CDATA[Marie-Anne]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Añón]]></surname>
<given-names><![CDATA[Ximena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Casada]]></surname>
<given-names><![CDATA[Victoria]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sosa]]></surname>
<given-names><![CDATA[Leonardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de la República Facultad de Medicina Clínica Médica B]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<volume>5</volume>
<numero>1</numero>
<fpage>41</fpage>
<lpage>46</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S2393-67972020000100041&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S2393-67972020000100041&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S2393-67972020000100041&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen. La hemofilia adquirida es un trastorno de la coagulación poco frecuente causado por autoanticuerpos circulantes que inhiben factores de la coagulación, principalmente el F VIII. Un porcentaje considerable de pacientes con hemofilia adquirida mueren a causa de un diagnóstico tardío con el consecuente retraso en el inicio del tratamiento. Los objetivos principales del tratamiento son controlar el sangrado, erradicar el inhibidor y tratar los trastornos subyacentes que se logren identificar. Presentamos el caso de una mujer de 72 años con el antecedente de una artritis reumatoidea que se presentó con un síndrome hemorragíparo de tipo coagulopático de aparición espontánea.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract. Acquired hemophilia is a rare coagulation disorder caused by circulating autoantibodies that inhibit coagulation factors, primarily F VIII. A considerable percentage of patients with acquired hemophilia die due to a late diagnosis with the consequent delay in the start of treatment. The main goals of treatment are to control bleeding, eradicate the inhibitor and treat underlying disorders that can be identified. We present the case of a 72-year-old woman with a history of rheumatoid arthritis who presented with a coagulopathic hemorrhagic syndrome of spontaneous onset.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo. A hemofilia adquirida é um distúrbio raro da coagulação causado por autoanticorpos circulantes que inibem fatores de coagulação, principalmente F VIII. Uma porcentagem considerável de pacientes com hemofilia adquirida morre devido a um diagnóstico tardio com o consequente atraso no início do tratamento. Os principais objetivos do tratamento são controlar o sangramento, erradicar o inibidor e tratar os distúrbios subjacentes que podem ser identificados. Apresentamos o caso de uma mulher de 72 anos com história de artrite reumatoide que apresentou síndrome hemorrágica coagulopática de início espontâneo.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[autoanticuerpos]]></kwd>
<kwd lng="es"><![CDATA[factor VIII]]></kwd>
<kwd lng="es"><![CDATA[hemofilia adquirida]]></kwd>
<kwd lng="en"><![CDATA[autoantibodies]]></kwd>
<kwd lng="en"><![CDATA[factor VIII]]></kwd>
<kwd lng="en"><![CDATA[Acquired hemophilia]]></kwd>
<kwd lng="pt"><![CDATA[autoanticorpos]]></kwd>
<kwd lng="pt"><![CDATA[fator VIII]]></kwd>
<kwd lng="pt"><![CDATA[Hemofilia adquirida]]></kwd>
</kwd-group>
</article-meta>
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<article-title xml:lang=""><![CDATA[International recommendations on the diagnosis and treatment of patients with acquired haemophilia]]></article-title>
<person-group person-group-type="editor">
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<source><![CDATA[Haematologica]]></source>
<year>2009</year>
<volume>94</volume>
<numero>4</numero>
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</article>
