<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2393-6797</journal-id>
<journal-title><![CDATA[Revista Uruguaya de Medicina Interna ]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Urug. Med. Int.]]></abbrev-journal-title>
<issn>2393-6797</issn>
<publisher>
<publisher-name><![CDATA[Sociedad de Medicina Interna del Uruguay]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2393-67972017000100013</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Sistema de Soporte Hepático Artificial: ¿Cuándo, a quien y por qué?]]></article-title>
<article-title xml:lang="en"><![CDATA[Artificial Hepatic Support System: When, to whom and why?]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Olivari]]></surname>
<given-names><![CDATA[Daniela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valverde]]></surname>
<given-names><![CDATA[Marcelo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gerona]]></surname>
<given-names><![CDATA[Solange]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Central de las Fuerzas Armadas  ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2017</year>
</pub-date>
<volume>2</volume>
<numero>1</numero>
<fpage>13</fpage>
<lpage>20</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S2393-67972017000100013&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S2393-67972017000100013&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S2393-67972017000100013&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La falla hepática es un problema de salud debido a su incidencia y su elevada mortalidad a corto plazo (40-80%). La súbita alteración de la función hepática lleva a las manifestaciones clínicas características, con desarrollo de encefalopatía hepática, ictericia, coagulopatía, susceptibilidad aumentada a infecciones, síndrome hepato-renal y falla multi-orgánica. Puede ocurrir en pacientes sin enfermedad hepática preexistente (Falla Hepática Aguda) o en un paciente con enfermedad hepática crónica que sufre una descompensación aguda (Falla Aguda sobre Crónica).El trasplante hepático sigue siendo la única alternativa terapéutica con beneficio demostrado en la sobrevida de estos pacientes. Sin embargo este no siempre puede llevarse a cabo debido a la escasez de órganos y/o la presencia de contraindicaciones para el mismo. En este escenario el sistema de soporte hepático artificial extracorpóreo Prometheus® disponible en Uruguay, es fundamental para mantener la condición del paciente hasta la recuperación espontánea de la función hepática o hasta que exista un órgano disponible para el trasplante.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Liver Failure is a health problem because of its incidence and high mortality in short terms (40% to 80%). The sudden impairment of liver function leads to its characteristic clinical manifestations with the development of hepatic encephalopathy, jaundice, coagulation disturbances, increased susceptibility to infections, hemodynamic instability, hepatorenal syndrome and multiorgan failure. It may develop in patients without preexisting liver disease (Acute Liver Failure) or in patients with chronic liver disease with an acute decompensation (Acute on Chronic Liver Failure). Liver transplantation is the only therapeutic choice with demonstrated benefit on survival. However it cannot always be done due to the shortage of donor organs and/or the presence of contraindications. In this scenario the extracorporeal liver support system Prometheus® available in Uruguay is really important for maintaining the patient s condition until the spontaneous recovery of the liver function or until a donor organ becomes available.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Falla Hepática]]></kwd>
<kwd lng="es"><![CDATA[Falla Hepática aguda]]></kwd>
<kwd lng="es"><![CDATA[Falla Hepática Aguda sobre Crónica. TrasplanteHepático]]></kwd>
<kwd lng="es"><![CDATA[SoporteHepático Artificial Extracorpóreo Prometheus®]]></kwd>
<kwd lng="en"><![CDATA[Liver Failure]]></kwd>
<kwd lng="en"><![CDATA[Acute Liver Failure]]></kwd>
<kwd lng="en"><![CDATA[Acute on Chronic Liver Failure]]></kwd>
<kwd lng="en"><![CDATA[Liver Transplantation]]></kwd>
<kwd lng="en"><![CDATA[Prometheus®]]></kwd>
</kwd-group>
</article-meta>
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