<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1688-9339</journal-id>
<journal-title><![CDATA[Odontoestomatología]]></journal-title>
<abbrev-journal-title><![CDATA[Odontoestomatología]]></abbrev-journal-title>
<issn>1688-9339</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Odontología - Universidad de la República]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1688-93392024000201235</article-id>
<article-id pub-id-type="doi">10.22592/ode2024n44e235</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Riesgo de transformación maligna de las lesiones verrucopapilares orales]]></article-title>
<article-title xml:lang="pt"><![CDATA[Risco de transformação maligna de lesões verrucopapilares orais]]></article-title>
<article-title xml:lang="en"><![CDATA[Risk of malignant transformation of oral verrucopapillary lesions]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García Barragán]]></surname>
<given-names><![CDATA[Jorge]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González González]]></surname>
<given-names><![CDATA[Rogelio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bologna Molina]]></surname>
<given-names><![CDATA[Ronell]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Toral Rizo]]></surname>
<given-names><![CDATA[Victor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villanueva Sánchez]]></surname>
<given-names><![CDATA[Germán]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López Verdín]]></surname>
<given-names><![CDATA[Sandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Guadalajara Centro Universitario de Ciencias de la Salud Departamento de Clínicas Odontológicas Integrales]]></institution>
<addr-line><![CDATA[Guadalajara ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Juárez del Estado de Durango Escuela de Odontología Departamento de Investigación]]></institution>
<addr-line><![CDATA[Durango ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de la República Facultad de Odontología Área de Patología Molecular, Diagnóstico en Patología y Medicina Oral]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Autónoma del Estado de México Facultad de Odontología Clínica Orocenter]]></institution>
<addr-line><![CDATA[Toluca de Lerdo ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad Nacional Autónoma de México Escuela Nacional de Estudios Superiores Unidad León Laboratorio de Investigación Interdisciplinaria, Área de Patología Oral y Maxilofacial]]></institution>
<addr-line><![CDATA[León Guanajuato]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Universidad de Guadalajara Centro Universitario de Ciencias de la Salud Instituto de Investigación en Odontología. Departamento de Clínicas Odontológicas Integrales]]></institution>
<addr-line><![CDATA[Guadalajara ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<volume>26</volume>
<numero>44</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S1688-93392024000201235&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S1688-93392024000201235&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S1688-93392024000201235&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivos: evaluar el riesgo potencial maligno mediante la tinción de azul de toluidina y gradificación displásica de las lesiones verrucopapilares de la cavidad oral (LVPO).  Materiales y métodos:  Se identificaron pacientes con LVPO localizados en la cavidad oral, se les aplicó azul de toluidina y posteriormente se evaluó los cambios displásicos para finalmente gradificarlos histopatológicamente en ausente, bajo o alto riesgo de transformación maligna. Pacientes que se negaron a la tinción con AT, no aceptaron la biopsia escisional o el tejido no poseía coilocitos, daño citopático asociado a la presencia del virus papiloma humano fueron eliminados del estudio.  Resultados:  se incluyeron 34 pacientes con LVPO, 4 con tinción positiva al AT (3 fueron considerados intensos y 1 leve).  Conclusiones: las LVPO pueden emitir una tinción positiva al azul de toluidina así como presentar una variedad heterogenea de cambios displásicos arquitecturales y citológicos evaluados histopatologicamente, que en la totalidad de las muestras, de acuerdo al sistema binario, son clasificadas como riesgo leve de transformación maligna.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo  Objetivos:  Avaliar o risco de potencial maligno através da coloração com azul de toluidina e da classificação displásica das lesões verrucopapilares da cavidade oral (LVPO).  Materiais e métodos:  Foram identificados pacientes com LVPO POVE localizados na cavidade oral nos quais foi aplicado azul de toluidina e posteriormente avaliadas as alterações displásicas para finalmente serem classificadas histopatologicamente como ausentes, baixo ou alto risco de transformação maligna. Os pacientes que recusaram a coloração com azul de toluidina AT, não aceitaram a biópsia excisional ou o tinha tecido insuficiente, presença de coilócitos ou dano citopático associado ao papilomavírus humano foram eliminados do estudo.  Resultados: Foram incluídos 34 pacientes com LVPO, dos quais 4 foram interpretados como tendo coloração positiva para azul de toluidina AT positiva, sendo 3 considerados intensos e 1 leve.  Conclusões:  A LVPO pode emitir coloração positiva para azul de toluidina, bem como apresentar uma variedade heterogênea de alterações arquitetônicas e citológicas displásicas avaliadas histopatologicamente, que em todas as amostras, segundo o sistema binário, são classificadas como leve risco de transformação maligna.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objectives: to evaluate the risk of malignant potential through toluidine blue staining and dysplastic grading of verrucous papillary lesions of the oral cavity (VPLO).  Materials and methods:  patients with VPLO located in the oral cavity were identified to whom toluidine blue was applied and dysplastic changes were subsequently evaluated and graded histopathologically as absent, low or high risk of malignant transformation. Patients who refused toluidine blue staining, did not accept excisional biopsy or had insufficient tissue, or the tissue lack of presence of koilocytes, damage associated with the presence of human papilloma virus were eliminated from the study.  Results: Thirty-four patients with VPLO were included, of which 4 were found to have positive toluidine blue staining. Of these, 3 cases were considered intense and 1 was mild.  Conclusions: VPLO may emit a positive stain to toluidine blue as well as present a heterogeneous variety of architectural and cytological dysplastic changes evaluated histopathologically, which in all samples, according to the binary system, are classified as low risk of malignant transformation.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Virus Papiloma Humano]]></kwd>
<kwd lng="es"><![CDATA[Azul de Toluidina]]></kwd>
<kwd lng="es"><![CDATA[Displasia]]></kwd>
<kwd lng="pt"><![CDATA[Papilomavírus Humano]]></kwd>
<kwd lng="pt"><![CDATA[Azul de Toluidina]]></kwd>
<kwd lng="pt"><![CDATA[Displasia]]></kwd>
<kwd lng="en"><![CDATA[Human Papillomavirus]]></kwd>
<kwd lng="en"><![CDATA[Toluidine blue]]></kwd>
<kwd lng="en"><![CDATA[dysplasia]]></kwd>
</kwd-group>
</article-meta>
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