<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1688-1249</journal-id>
<journal-title><![CDATA[Archivos de Pediatría del Uruguay]]></journal-title>
<abbrev-journal-title><![CDATA[Arch. Pediatr. Urug.]]></abbrev-journal-title>
<issn>1688-1249</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Uruguaya de Pediatría]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1688-12492025000301206</article-id>
<article-id pub-id-type="doi">10.31134/ap.96.18</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Isotretinoína para el tratamiento del acné en pediatría: ¿qué es lo que los pediatras deben saber?]]></article-title>
<article-title xml:lang="en"><![CDATA[Isotretinoin for the treatment of acne in pediatrics: what should pediatricians know?]]></article-title>
<article-title xml:lang="pt"><![CDATA[Isotretinoína para o tratamento da acne pediátrica: o que os pediatras devem saber?]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Méndez]]></surname>
<given-names><![CDATA[Lucía]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bermúdez]]></surname>
<given-names><![CDATA[Daniela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Acosta]]></surname>
<given-names><![CDATA[Agustina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,UDELAR Facultad de Medicina Unidad Académica Dermatología]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,UDELAR Facultad de Medicina Unidad Académica Dermatología]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,UDELAR Facultad de Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<volume>96</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S1688-12492025000301206&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S1688-12492025000301206&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S1688-12492025000301206&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La isotretinoína o ácido 13-cis-retinoico es un retinoide derivado de la vitamina A ampliamente utilizado en el tratamiento de casos severos de acné y otras afecciones dermatológicas. Este fármaco se distingue por su capacidad de actuar sobre múltiples aspectos fisiopatológicos del acné, como la reducción del tamaño y la actividad de las glándulas sebáceas, la disminución de la colonización por Cutibacterium acnes y la atenuación de la inflamación. Estas acciones no solo logran un control significativo del acné durante el tratamiento, sino que también pueden ofrecer un efecto sostenido a largo plazo debido a la remodelación estructural de las glándulas sebáceas, lo que disminuye la recurrencia. El acné es una enfermedad que puede dejar cicatrices físicas y psicológicas, por lo que el tratamiento temprano y eficaz es fundamental para prevenir estas complicaciones, mejorando la calidad de vida de los pacientes. Si bien el tratamiento del acné moderado-severo habitualmente es conducido por el dermatólogo, creemos importante que el pediatra esté familiarizado con este fármaco, sus indicaciones, efectos adversos más frecuentes, así como con las complicaciones que puedan presentarse.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Summary: Isotretinoin, or 13-cis-retinoic acid, is a retinoid derived from vitamin A widely used in the treatment of severe cases of acne and other dermatological conditions. This drug is distinguished by its ability to act on multiple pathophysiological aspects of acne, such as reducing the size and activity of the sebaceous glands, reducing colonization by Cutibacterium acnes and attenuating inflammation. These actions not only achieve significant acne control during treatment, but may also offer a sustained long-term effect due to structural remodeling of the sebaceous glands, which decreases recurrence. Acne is a disease that can leave physical and psychological scars, so early and effective treatment is essential to prevent these complications, improving the quality of life of these patients. Although the treatment of moderate-severe acne is usually conducted by a dermatologist, acne isotretinoina we believe it is important that pediatricians become familiar with this drug, its indications, the most frequent adverse effects, as well as the complications that may arise.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo: A isotretinoína, ou ácido 13-cis-retinóico, é um retinóide derivado da vitamina A amplamente utilizado no tratamento de casos graves de acne e outras condições dermatológicas. Este medicamento distingue-se pela sua capacidade de atuar em múltiplos aspectos fisiopatológicos da acne, como a redução do tamanho e da atividade das glândulas sebáceas, a redução da colonização por Cutibacterium acnés e a atenuação da inflamação. Estas ações não só alcançam um controle significativo da acne durante o tratamento, mas também podem oferecer um efeito sustentado a longo prazo devido à remodelação estrutural das glândulas sebáceas, o que diminui a recorrência. A acne é uma doença que pode deixar cicatrizes físicas e psicológicas, por isso o tratamento precoce e eficaz é fundamental para prevenir essas complicações, melhorando a qualidade de vida dos pacientes. Embora o tratamento da acne moderada a grave seja geralmente realizado por um dermatologista, acreditamos ser importante que o pediatra conheça este medicamento, suas indicações, os efeitos adversos mais frequentes, bem como as complicações que podem surgir.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Isotretinoína]]></kwd>
<kwd lng="es"><![CDATA[Acné Vulgar]]></kwd>
<kwd lng="es"><![CDATA[Pediatría]]></kwd>
<kwd lng="en"><![CDATA[Isotretinoin]]></kwd>
<kwd lng="en"><![CDATA[Acne Vulgaris]]></kwd>
<kwd lng="en"><![CDATA[Pediatrics]]></kwd>
<kwd lng="pt"><![CDATA[Isotretinoína]]></kwd>
<kwd lng="pt"><![CDATA[Acne Vulgar]]></kwd>
<kwd lng="pt"><![CDATA[Pediatria]]></kwd>
</kwd-group>
</article-meta>
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