<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1688-0390</journal-id>
<journal-title><![CDATA[Revista Médica del Uruguay]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Méd. Urug.]]></abbrev-journal-title>
<issn>1688-0390</issn>
<publisher>
<publisher-name><![CDATA[Sindicato Médico del Uruguay]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1688-03902025000301203</article-id>
<article-id pub-id-type="doi">10.29193/rmu.41.3.3</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Riesgo de eventos cardiovasculares tras COVID-19 e infecciones respiratorias: un estudio de base poblacional]]></article-title>
<article-title xml:lang="en"><![CDATA[Risk of cardiovascular events after COVID-19 and respiratory infections: a population-based study]]></article-title>
<article-title xml:lang="pt"><![CDATA[Risco de eventos cardiovasculares após COVID-19 e infecções respiratórias: um estudo de base populacional]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Dayan]]></surname>
<given-names><![CDATA[Víctor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cuesta]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cavalleri]]></surname>
<given-names><![CDATA[Fiorella]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Artucio]]></surname>
<given-names><![CDATA[Carolina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Muñoz]]></surname>
<given-names><![CDATA[Matías]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garre]]></surname>
<given-names><![CDATA[Laura]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital de Clínicas  ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Comisión Honoraria para la Salud Cardiovascular  ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<volume>41</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S1688-03902025000301203&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S1688-03902025000301203&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S1688-03902025000301203&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: no existen análisis comparativos entre el COVID-19 y otras infecciones respiratorias en cuanto al riesgo de eventos cardiovasculares (CV). Nuestro objetivo fue evaluar el riesgo de eventos CV en una cohorte nacional de pacientes ingresados por COVID-19 respiratorio u otras infecciones respiratorias.  Materiales y método: realizamos un estudio retrospectivo nacional que incluyó a pacientes que ingresaron por infección por COVID-19 u otra infección respiratoria entre enero de 2020 y diciembre de 2021. El resultado primario fue el evento compuesto de reingreso hospitalario por causas cardiovasculares (RI CV) o muerte CV 90 días después del ingreso índice. Los resultados secundarios incluyeron el riesgo independiente de muerte CV. El modelo de riesgos de sub distribución se ajustó para tener en cuenta los eventos competitivos (muerte por otras causas).  Resultados: 23.041 personas (11.858 respiratorias y 11.183 en la cohorte COVID-19 respectivamente) cumplieron los criterios de inclusión. La supervivencia para el punto final compuesto (RI CV o muerte CV) fue significativamente mayor para la cohorte COVID-19 (99%; IC del 95%: 98%, 99%) en comparación con la cohorte respiratoria (95%; IC del 95%: 95%, 96%; p &lt; 0,001). De manera similar, la supervivencia para la muerte CV fue significativamente mayor para COVID-19 (99%; IC del 95%: 99%, 99%) en comparación con la cohorte respiratoria (97%; IC del 95%: 96%, 97%; p &lt; 0,001). Tras ajustar por edad, sexo y seguro médico, la cohorte respiratoria fue un predictor independiente de mortalidad CV o AR CV (HR=2,72; IC del 95 %: 2,28, 3,25. p&lt;0,05). La cohorte respiratoria se asoció con un mayor riesgo de muerte CV (HR=3,66; IC del 95%: 2,87, 4,67. p&lt;0,05).  Conclusiones: nuestros datos muestran que los pacientes ingresados con COVID-19 no tienen un mayor riesgo de eventos CV (RI CV o muertes CV) en comparación con otras infecciones respiratorias.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: no comparative analyses exist between COVID-19 and other respiratory infections regarding the risk of cardiovascular (CV) events. Our aim was to assess the risk of CV events in a national cohort of patients hospitalized due to respiratory COVID-19 or other respiratory infections.  Materials and methods: we conducted a national retrospective study including patients admitted for COVID-19 or another respiratory infection between January 2020 and December 2021. The primary outcome was the composite of hospital readmission due to CV causes (CV readmission) or CV death within 90 days of the index admission. Secondary outcomes included the independent risk of CV death. A subdistribution hazard model was used to account for competing risks (non-CV death).  Results: a total of 23,041 patients met the inclusion criteria (11,858 in the respiratory cohort and 11,183 in the COVID-19 cohort). Survival for the composite outcome (CV readmission or CV death) was significantly higher in the COVID-19 cohort (99%; 95% CI: 98%, 99%) compared to the respiratory cohort (95%; 95% CI: 95%, 96%; p &lt; 0.001). Similarly, CV death-free survival was significantly higher in the COVID-19 cohort (99%; 95% CI: 99%, 99%) than in the respiratory cohort (97%; 95% CI: 96%, 97%; p &lt; 0.001). After adjusting for age, sex, and health insurance, the respiratory cohort was an independent predictor of CV death or CV readmission (HR=2.72; 95% CI: 2.28, 3.25; p&lt;0.05). The respiratory cohort was also associated with a higher risk of CV death (HR=3.66; 95% CI: 2.87, 4.67; p&lt;0.05).  Conclusions: our data show that patients hospitalized with COVID-19 do not have a higher risk of CV events (CV readmission or CV death) compared to those hospitalized with other respiratory infections.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo  Introdução: não existem análises comparativas entre a COVID-19 e outras infecções respiratórias quanto ao risco de eventos cardiovasculares (CV). Nosso objetivo foi avaliar o risco de eventos CV em uma coorte nacional de pacientes internados por COVID-19 respiratória ou outras infecções respiratórias.  Materiais e métodos: realizamos um estudo retrospectivo nacional que incluiu pacientes internados por infecção por COVID-19 ou outra infecção respiratória entre janeiro de 2020 e dezembro de 2021. O desfecho primário foi o evento composto de reinternação hospitalar por causas cardiovasculares (RCV) ou morte CV em até 90 dias após a internação índice. Os desfechos secundários incluíram o risco independente de morte CV. O modelo de riscos de subdistribuição foi ajustado para considerar eventos competitivos (morte por outras causas).  Resultados: um total de 23.041 pacientes atenderam aos critérios de inclusão (11.858 na coorte respiratória e 11.183 na coorte COVID-19). A sobrevida para o desfecho composto (RCV ou morte CV) foi significativamente maior na coorte COVID-19 (99%; IC 95%: 98%, 99%) em comparação com a coorte respiratória (95%; IC 95%: 95%, 96%; p &lt; 0,001). Da mesma forma, a sobrevida sem morte CV foi maior na coorte COVID-19 (99%; IC 95%: 99%, 99%) em relação à coorte respiratória (97%; IC 95%: 96%, 97%; p &lt; 0,001). Após ajuste por idade, sexo e seguro de saúde, a coorte respiratória foi um preditor independente de morte CV ou RCV (HR=2,72; IC 95%: 2,28, 3,25; p&lt;0,05). A coorte respiratória também foi associada a maior risco de morte CV (HR=3,66; IC 95%: 2,87, 4,67; p&lt;0,05).  Conclusões: nossos dados mostram que os pacientes internados com COVID-19 não apresentam maior risco de eventos CV (RCV ou morte CV) em comparação com aqueles com outras infecções respiratórias.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[Infecciones respiratorias]]></kwd>
<kwd lng="es"><![CDATA[Mortalidad]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[Respiratory infections]]></kwd>
<kwd lng="en"><![CDATA[Mortality]]></kwd>
<kwd lng="pt"><![CDATA[COVID-19]]></kwd>
<kwd lng="pt"><![CDATA[Infecções respiratórias]]></kwd>
<kwd lng="pt"><![CDATA[Mortalidade]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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