<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1688-0390</journal-id>
<journal-title><![CDATA[Revista Médica del Uruguay]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Méd. Urug.]]></abbrev-journal-title>
<issn>1688-0390</issn>
<publisher>
<publisher-name><![CDATA[Sindicato Médico del Uruguay]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1688-03902021000301203</article-id>
<article-id pub-id-type="doi">10.29193/rmu.37.3.3</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Evaluación del consumo en antidepresivos en la población uruguaya entre 2010 y 2014]]></article-title>
<article-title xml:lang="en"><![CDATA[Evaluation of antidepressant use in the Uruguayan population between 2010 and 2014]]></article-title>
<article-title xml:lang="pt"><![CDATA[Avaliação do uso de antidepressivos na população uruguaia entre 2010 e 2014]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pagano]]></surname>
<given-names><![CDATA[Emiliano]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Domínguez]]></surname>
<given-names><![CDATA[Viviana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Speranza]]></surname>
<given-names><![CDATA[Noelia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barboza]]></surname>
<given-names><![CDATA[Leandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tamosiunas]]></surname>
<given-names><![CDATA[Gustavo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de la República Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de la República Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de la República Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de la República Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad de la República Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2021</year>
</pub-date>
<volume>37</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S1688-03902021000301203&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S1688-03902021000301203&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S1688-03902021000301203&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Objetivo:  conocer el consumo de antidepresivos en la población uruguaya en el período 2010-2014.  Material y método:  se realizó un estudio de utilización de medicamentos para evaluar el consumo de antidepresivos utilizando el dato de dispensación de medicamentos de las farmacias de las instituciones participantes. Se utilizó la variable dosis diaria definida (DDD) por 1.000 habitantes/día (DHD).  Resultados:  se incluyó el 69% de la población uruguaya. Las DHD globales de antidepresivos para los años 2010, 2011, 2012, 2013 y 2014 fueron: 26,49, 29,71, 30,17, 30,79 y 32,55 (promedio en los 5 años: 30,04) siendo el aumento porcentual global en dicho período de 22,88%. Los ISRS fueron el grupo de antidepresivos más consumidos. Sertralina fue el antidepresivo más consumido en los 5 años de estudio (DHD 13,65), y el de mayor aumento porcentual fue duloxetina, seguido por escitalopram.  Conclusión:  el consumo de antidepresivos a nivel nacional en el período analizado es inferior al constatado en otros países, con una tendencia al aumento. Éste puede ser visto como una señal para la evaluación evolutiva en el periodo 2015-2020 y para realizar análisis de las prácticas de prescripción y actuales indicaciones, utilizando otras metodologías como los estudios de prevalencia o estudios de indicación-prescripción o de prescripción-indicación.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Objective:  to learn about antidepressant use in the Uruguayan population between 2010 and 2014.  Method: the use of drugs was studied to evaluate the consumption of antidepressants by analysing the dispensing of drugs in the pharmacies that are part of the participating institutions. The study used the defined daily dose variable (DDD) by 1.000 inhabitants/day (DHD).  Results:  69% of the Uruguayan population was included in the study. The global antidepressant dose by inhabitants per day for 2010, 2011, 2012, 2013 and 2014 was 26,49, 29,71, 30,17; 30,79 and 32,55 respectively (average in the five years 30,4) being the global increase of percentage 22,88%5 for that period. The SSRIs (selective serotonin reuptake inhibitor) were the most widely used group of antidepressants. Sertraline was the antidepressant of greatest consumption in the 5 years of the study (DHD 13,65), and the one that presented the highest percentage increase was duloxetine, followed by escitalopram.  Conclusion: antidepressant use at the national level during the period analysed is lower than that seen in other countries, although a tendency to increase was found. This may be interpreted as a sign for the need to evaluate the evolution in the 2015-2020 period, and to conduct studies on prescription practices and current indications using other methodologies, such as prevalence studies or indication-prescription or prescription-indication studies.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Objetivo:  conhecer o consumo de antidepressivos na população uruguaia no período 2010-2014.  Material e método:  foi realizado um estudo sobre o uso de medicamentos para avaliar o consumo de antidepressivos a partir dos dados de dispensação de medicamentos nas farmácias das instituições participantes. Foi utilizada a variável dose diária definida (DDD) por 1.000 habitantes/dia (DHD).  Resultados:  69% da população uruguaia foram incluídas. Os DHDs globais de antidepressivos para os anos de 2010, 2011, 2012, 2013 e 2014 foram: 26,49, 29,71, 30,17; 30,79 e 32,55 (média nos 5 anos, 30,04) sendo o aumento percentual global no referido período de 22,88%. Os inibidores seletivos da recaptação da serotonina foram o grupo de antidepressivos mais amplamente utilizado. A sertralina foi o antidepressivo mais utilizado nos 5 anos do estudo (DHD 13,65), e o que apresentou maior aumento percentual foi a duloxetina, seguida do escitalopram.  Conclusão:  o consumo de antidepressivos em nível nacional no período analisado é inferior ao encontrado em outros países, com tendência de aumento. Isto pode ser visto como um sinal para a avaliação evolutiva no período 2015-2020 e para a realização de análises das práticas de prescrição e indicações atuais, utilizando outras metodologias como estudos de prevalência ou estudos de indicação-prescrição ou prescrição-indicação.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Antidepresivos.]]></kwd>
<kwd lng="en"><![CDATA[Antidepressive agents.]]></kwd>
<kwd lng="pt"><![CDATA[Antidepressivos.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="book">
<collab>National Institute for Health and Care Excellence</collab>
<source><![CDATA[Antidepressant treatment in adults]]></source>
<year>2021</year>
<publisher-name><![CDATA[NICE]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Katzman]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Bleau]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Blier]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Chokka]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Kjernisted]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Van Ameringen]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders]]></article-title>
<source><![CDATA[BMC Psychiatry]]></source>
<year>2014</year>
<volume>14</volume>
<numero>Suppl 1</numero>
<issue>Suppl 1</issue>
<page-range>S1</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="book">
<collab>Organización Mundial de la Salud</collab>
<source><![CDATA[Depresión]]></source>
<year>2020</year>
<publisher-name><![CDATA[OMS]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="book">
<collab>World Health Organization</collab>
<source><![CDATA[Depression and other mental common disorders: global health estimates]]></source>
<year>2017</year>
<publisher-name><![CDATA[WHO]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="">
<collab>Uruguay. Ministerio de Salud Pública</collab>
<source><![CDATA[Día Nacional de Prevención del Suicidio. 17 de julio de 2020]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tognoni]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Laporte]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[From clinical trials to drug utilization studies]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Dukes]]></surname>
<given-names><![CDATA[MN]]></given-names>
</name>
</person-group>
<source><![CDATA[Drug utilization studies: methods and uses]]></source>
<year>1993</year>
<page-range>23-42</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Haaijer-Ruskamp]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Hemminki]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The social aspects of drug use]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Dukes]]></surname>
<given-names><![CDATA[MN]]></given-names>
</name>
</person-group>
<source><![CDATA[Drug utilization studies: methods and uses]]></source>
<year>1993</year>
<page-range>97-124</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Capellá]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Laporte]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Métodos aplicados en estudios descriptivos de utilización de medicamentos]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Laporte]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
<name>
<surname><![CDATA[Tognoni]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Principios de epidemiología del medicamento]]></source>
<year>1998</year>
<edition>2</edition>
<page-range>67-92</page-range><publisher-loc><![CDATA[Barcelona ]]></publisher-loc>
<publisher-name><![CDATA[Masson-Salvat]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="">
<collab>Junta Nacional de Droga</collab>
<source><![CDATA[VII Encuesta nacional sobre consumo de drogas en población general. Informe de investigación. Año 2019]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Teixeira]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Imbriago]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Sarries]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Utilización de antidepresivos en pacientes ambulatorios del Hospital Policial]]></article-title>
<source><![CDATA[Rev Psiquiatr Urug]]></source>
<year>2015</year>
<volume>79</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>39-48</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="book">
<collab>Uruguay. Ministerio de Salud Pública</collab>
<source><![CDATA[Dispensación de medicamentos controlados en Uruguay. Periodo: enero-octubre 2018]]></source>
<year>2018</year>
<publisher-name><![CDATA[MSP]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="book">
<collab>España. Ministerio de Sanidad, Servicios Sociales e Igualdad. Agencia Española de Medicamentos y Productos Sanitarios</collab>
<source><![CDATA[Utilización de medicamentos antidepresivos en España durante el periodo 2000-2013]]></source>
<year>2015</year>
<publisher-name><![CDATA[AEMPS]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gusmão]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Quintão]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The use of antidepressants in Portugal 1995-2009]]></article-title>
<source><![CDATA[Europ Psychiatr]]></source>
<year>2012</year>
<volume>27</volume>
<numero>^s1</numero>
<issue>^s1</issue>
<supplement>1</supplement>
<page-range>1</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Spence]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Roberts]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ariti]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Bardsley]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Focus on: antidepressant prescribing. Trends in the prescribing of antidepressants in primary care.]]></source>
<year>2014</year>
<publisher-name><![CDATA[The Health Foundation]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pratt]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
<name>
<surname><![CDATA[Brody]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
<name>
<surname><![CDATA[Gu]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antidepressant use in persons aged 12 and over United States, 2005-2008]]></article-title>
<source><![CDATA[NCHS Data Brief]]></source>
<year>2011</year>
<numero>76</numero>
<issue>76</issue>
<page-range>1-8</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jirón]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Machado]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ruiz]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Consumo de antidepresivos en Chile entre 1992 y 2004]]></article-title>
<source><![CDATA[Rev méd Chile]]></source>
<year>2008</year>
<volume>136</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1147-54</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="">
<collab>UdelaR. Facultad de Medicina. Departamento de Farmacología y Terapéutica</collab>
<source><![CDATA[Observatorio de Medicamentos]]></source>
<year>2020</year>
</nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arnau]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Vallano]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estudios de utilización de medicamentos]]></article-title>
<source><![CDATA[Medic Salud]]></source>
<year>2000</year>
<volume>3</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>72-7</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="">
<collab>WHO Collaborating Centre for Drug Statistics Methodolog</collab>
<source><![CDATA[ATC DDD Index]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="">
<collab>Uruguay. Instituto Nacional de Estadística</collab>
<source><![CDATA[Estimaciones y Proyecciones de Población]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Almada]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Miraballes]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Agrafojo]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Frecuencia de depresión en los pacientes que consultan en las policlínicas de medicina interna del Hospital de Clínicas Dr Manuel Quintela]]></article-title>
<source><![CDATA[Rev Psiquiatr Urug]]></source>
<year>2014</year>
<volume>78</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>116-30</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="book">
<collab>Organización Panamericana de la Salud</collab>
<source><![CDATA["Depresión: hablemos", dice la OMS, mientras la depresión encabeza la lista de causas de enfermedad]]></source>
<year>2017</year>
<publisher-loc><![CDATA[Ginebra/Washington ]]></publisher-loc>
<publisher-name><![CDATA[OMS/OPS]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="book">
<collab>Uruguay. Ministerio de Salud Pública</collab>
<source><![CDATA[Consumo de Benzodiazepinas y otros sicofármacos en territorio nacional. Periodo: Enero 2014 - Junio 2016]]></source>
<year>2017</year>
<publisher-name><![CDATA[MSP]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="book">
<collab>National Services Scotland</collab>
<source><![CDATA[Medicines for mental health. Financial years 2003/04 to 2012/13]]></source>
<year>2013</year>
<publisher-name><![CDATA[NHS]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="">
<source><![CDATA[Trends in antidepressant consumption. (Presentado en el OECD Health Data National Correspondents meeting, Paris 23 October 2014)]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brett]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Karanges]]></surname>
<given-names><![CDATA[EA]]></given-names>
</name>
<name>
<surname><![CDATA[Daniels]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Buckley]]></surname>
<given-names><![CDATA[NA]]></given-names>
</name>
<name>
<surname><![CDATA[Schneider]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Nassir]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Psychotropic medication use in Australia, 2007 to 2015: changes in annual incidence, prevalence and treatment exposure]]></article-title>
<source><![CDATA[Aust N Z J Psychiatry]]></source>
<year>2017</year>
<volume>51</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>990-9</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Speranza]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Tamosiunas]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Ormaechea]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Perfil de riesgo de los antidepresivos inhibidores selectivos de la recaptación de serotonina (ISRS)]]></article-title>
<source><![CDATA[Rev Urug Med Int]]></source>
<year>2016</year>
<volume>1</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>25-33</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ali]]></surname>
<given-names><![CDATA[MK]]></given-names>
</name>
<name>
<surname><![CDATA[Lam]]></surname>
<given-names><![CDATA[RW]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparative efficacy of escitalopram in the treatment of major depressive disorder]]></article-title>
<source><![CDATA[Neuropsychiatr Dis Treat]]></source>
<year>2011</year>
<volume>7</volume>
<page-range>39-49</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cipriani]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Santilli]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Furukawa]]></surname>
<given-names><![CDATA[TA]]></given-names>
</name>
<name>
<surname><![CDATA[Signoretti]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Nakagawa]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[McGuire]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Escitalopram versus other antidepressive agents for depression]]></article-title>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2009</year>
<numero>2</numero>
<issue>2</issue>
<page-range>CD006532</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Simó Miñana]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aten]]></article-title>
<source><![CDATA[Primaria]]></source>
<year>2012</year>
<volume>44</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>335-47</page-range></nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="book">
<collab>España. Ministerio de Sanidad, Agencia Española de Medicamentos y Productos Sanitarios</collab>
<source><![CDATA[Agomelatina (Thymanax(r), Valdoxan(r)) y toxicidad hepática: nuevas recomendaciones de uso]]></source>
<year>2014</year>
<publisher-name><![CDATA[AEMPS]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pagano]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Perfil farmacológico de agomelatina, un nuevo antidepresivo]]></article-title>
<source><![CDATA[Bol Farmacol]]></source>
<year>2016</year>
<volume>7</volume>
<numero>2</numero>
<issue>2</issue>
</nlm-citation>
</ref>
<ref id="B33">
<label>33</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kennedy]]></surname>
<given-names><![CDATA[SH]]></given-names>
</name>
<name>
<surname><![CDATA[Lam]]></surname>
<given-names><![CDATA[RW]]></given-names>
</name>
<name>
<surname><![CDATA[McIntyre]]></surname>
<given-names><![CDATA[RS]]></given-names>
</name>
<name>
<surname><![CDATA[Tourjman]]></surname>
<given-names><![CDATA[SV]]></given-names>
</name>
<name>
<surname><![CDATA[Bhat]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Blier]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016. Clinical guidelines for the management of adults with major depressive disorder: Section 3. Pharmacological treatments]]></article-title>
<source><![CDATA[Can J Psychiatry]]></source>
<year>2016</year>
<volume>61</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>540-60</page-range></nlm-citation>
</ref>
<ref id="B34">
<label>34</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hansen]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
<name>
<surname><![CDATA[Gartlehner]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Lohr]]></surname>
<given-names><![CDATA[KN]]></given-names>
</name>
<name>
<surname><![CDATA[Gaynes]]></surname>
<given-names><![CDATA[BN]]></given-names>
</name>
<name>
<surname><![CDATA[Carey]]></surname>
<given-names><![CDATA[TS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Efficacy and safety of second-generation antidepressants in the treatment of major depressive disorder]]></article-title>
<source><![CDATA[Ann Intern Med]]></source>
<year>2005</year>
<volume>143</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>415-26</page-range></nlm-citation>
</ref>
<ref id="B35">
<label>35</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pagano]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Domínguez]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Barboza]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Speranza]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Tamosiunas]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mitos en el uso de antidepresivos(1) ¿Cuáles pacientes con depresión precisan un antidepresivo?]]></article-title>
<source><![CDATA[Bol Farmacol]]></source>
<year>2015</year>
<volume>6</volume>
<numero>3</numero>
<issue>3</issue>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
