<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2393-6797</journal-id>
<journal-title><![CDATA[Revista Uruguaya de Medicina Interna ]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Urug. Med. Int.]]></abbrev-journal-title>
<issn>2393-6797</issn>
<publisher>
<publisher-name><![CDATA[Sociedad de Medicina Interna del Uruguay]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2393-67972026000101404</article-id>
<article-id pub-id-type="doi">10.26445/11.01.6</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome de Goodpasture: abordaje diagnóstico desde la sala de urgencias. Reporte de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Goodpasture syndrome: diagnostic approach from the emergency room. Case report]]></article-title>
<article-title xml:lang="pt"><![CDATA[Síndrome de Goodpasture: abordagem diagnóstica no pronto-socorro. Relato de caso]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pretelt Gazabón]]></surname>
<given-names><![CDATA[Juan Manuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vélez Lora]]></surname>
<given-names><![CDATA[Michael Mario]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vargas Plazas]]></surname>
<given-names><![CDATA[Eduard Orlando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Orozco Álvarez]]></surname>
<given-names><![CDATA[Lorena Rocío]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Caicedo Sánchez]]></surname>
<given-names><![CDATA[Diana Carolina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortiz Mejía]]></surname>
<given-names><![CDATA[Nelson Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vargas Gómez]]></surname>
<given-names><![CDATA[Jennifer]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Libre de Barranquilla  ]]></institution>
<addr-line><![CDATA[Atlántico ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Simón Bolívar de Barranquilla Clínica General del Norte ]]></institution>
<addr-line><![CDATA[Barranquilla ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2026</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2026</year>
</pub-date>
<volume>11</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S2393-67972026000101404&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S2393-67972026000101404&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S2393-67972026000101404&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El síndrome de Goodpasture es una vasculitis de pequeños vasos mediada por autoanticuerpos dirigidos contra el colágeno tipo IV, presente en las membranas basales glomerular y alveolar. Clínicamente se manifiesta como un síndrome pulmón-riñón, caracterizado por hemorragia alveolar difusa y glomerulonefritis rápidamente progresiva. Se presenta el caso de una mujer de 61 años con hemoptisis, anemia grave e insuficiencia renal aguda, en quien se documentaron hallazgos radiológicos compatibles con hemorragia alveolar y niveles elevados de anticuerpos anti-membrana basal glomerular. A pesar del tratamiento con corticoides, plasmaféresis y ciclofosfamida, la evolución fue desfavorable. Este caso ilustra la agresividad del síndrome de Goodpasture en adultos mayores, la importancia del diagnóstico temprano, el inicio oportuno del tratamiento inmunosupresor y el abordaje multidisciplinario.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Goodpasture syndrome is a small-vessel vasculitis mediated by autoantibodies directed against type IV collagen, which is found in the glomerular and alveolar basement membranes. Clinically, it presents as a pulmonary-renal syndrome, characterized by diffuse alveolar hemorrhage and rapidly progressive glomerulonephritis. We report the case of a 61-year-old woman with hemoptysis, severe anemia, and acute kidney injury, in whom radiologic findings were consistent with alveolar hemorrhage and high titers of anti-glomerular basement membrane antibodies were documented. Despite treatment with corticosteroids, plasmapheresis, and cyclophosphamide, the clinical course was unfavorable. This case illustrates the aggressiveness of Goodpasture syndrome in older adults, highlighting the importance of early diagnosis, timely initiation of immunosuppressive therapy, and multidisciplinary management.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo A síndrome de Goodpasture é uma vasculite de pequenos vasos mediada por auto-anticorpos direcionados contra o colágeno tipo IV, presente nas membranas basais glomerular e alveolar. Clinicamente, manifesta-se como uma síndrome pulmão-rim, caracterizada por hemorragia alveolar difusa e glomerulonefrite rapidamente progressiva. Apresenta-se o caso de uma mulher de 61 anos com hemoptise, anemia grave e insuficiência renal aguda, na qual foram documentados achados radiológicos compatíveis com hemorragia alveolar e títulos elevados de anticorpos anti-membrana basal glomerular. Apesar do tratamento com corticosteroides, plasmaférese e ciclofosfamida, a evolução foi desfavorável. Este caso ilustra a agressividade da síndrome de Goodpasture em pacientes idosos, ressaltando a importância do diagnóstico precoce, início oportuno da terapia imunossupressora e abordagem multidisciplinar.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Síndrome de Goodpasture, Enfermedad por anticuerpos contra la membrana basal glomerular]]></kwd>
<kwd lng="es"><![CDATA[Glomerulonefritis]]></kwd>
<kwd lng="es"><![CDATA[Hemorragia alveolar difusa]]></kwd>
<kwd lng="en"><![CDATA[Goodpasture Syndrome]]></kwd>
<kwd lng="en"><![CDATA[Anti-Glomerular Basement Membrane Disease]]></kwd>
<kwd lng="en"><![CDATA[Glomerulonephritis]]></kwd>
<kwd lng="en"><![CDATA[Diffuse alveolar hemorrhage]]></kwd>
<kwd lng="pt"><![CDATA[Síndrome de Goodpasture]]></kwd>
<kwd lng="pt"><![CDATA[Doença por anticorpos anti-membrana basal glomerular]]></kwd>
<kwd lng="pt"><![CDATA[Glomerulonefrite]]></kwd>
<kwd lng="pt"><![CDATA[Hemorragia alveolar difusa]]></kwd>
</kwd-group>
</article-meta>
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