<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2393-6797</journal-id>
<journal-title><![CDATA[Revista Uruguaya de Medicina Interna ]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Urug. Med. Int.]]></abbrev-journal-title>
<issn>2393-6797</issn>
<publisher>
<publisher-name><![CDATA[Sociedad de Medicina Interna del Uruguay]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2393-67972022000100041</article-id>
<article-id pub-id-type="doi">10.26445/07.01.5</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Neutropenia febril inducida por metimazol]]></article-title>
<article-title xml:lang="en"><![CDATA[Methimazole-induced febrile neutropenia]]></article-title>
<article-title xml:lang="pt"><![CDATA[Neutropenia febril induzida por metimazol]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Baccelli]]></surname>
<given-names><![CDATA[Augusto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sugo]]></surname>
<given-names><![CDATA[Valentina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Perendones]]></surname>
<given-names><![CDATA[Mercedes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de la República (UdelaR) Facultad de Medicina Clínica Médica 2]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<volume>7</volume>
<numero>1</numero>
<fpage>41</fpage>
<lpage>48</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S2393-67972022000100041&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S2393-67972022000100041&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S2393-67972022000100041&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: Los antitiroideos de síntesis como el metimazol, tienen como uno de sus eventos adversos la neutropenia. Si bien la misma es de baja frecuencia (0.1 - 1%), pueden conducir a infecciones graves con una mortalidad que llega al 4%. El mecanismo patogénico no está claro, se plantean una serie de alteraciones inmunológicas. El tratamiento consiste en la suspensión inmediata del medicamento y el tratamiento del proceso infeccioso. Se presentan dos casos clínicos que se manifiestan una con una infección de piel y partes blandas, y la otra con una neumopatía aguda comunitaria, constatándose una neutropenia febril severa que se vincula al uso de metimazol.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Synthetic antithyroid drugs us methimazole have neutropenia as one of their adverse events. Although it is of low frequency (0.1 - 1%), it can lead to serious infections with a mortality rate of up to 4%. The pathogenic mechanism is not clear, a series of immunological alterations are proposed. The treatment consists of the immediate suspension of the medication and the treatment of the infectious process. Two clinical cases are presented that manifest one with a skin and soft tissue infection, and the other with an acute community lung disease, confirming a severe febrile neutropenia that is linked to the use of methimazole.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo: Drogas antitireoidianas sintéticas como metimazol, têm a neutropenia como um de seus eventos adversos. Embora seja de baixa frequência (0,1 - 1%), pode levar a infecções graves com taxa de mortalidade de até 4%. O mecanismo patogênico não está claro, uma série de alterações imunológicas são propostas. O tratamento consiste na suspensão imediata da medicação e no tratamento do processo infeccioso. São apresentados dois casos clínicos que manifestam um com infecção de pele e tecidos moles e outro com doença pulmonar comunitária aguda, confirmando uma neutropenia febril grave associada ao uso de metimazol.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[metimazol]]></kwd>
<kwd lng="es"><![CDATA[neutropenia febril]]></kwd>
<kwd lng="en"><![CDATA[methimazole]]></kwd>
<kwd lng="en"><![CDATA[febrile neutropenia]]></kwd>
<kwd lng="pt"><![CDATA[metimazol]]></kwd>
<kwd lng="pt"><![CDATA[neutropenia febril]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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