<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1688-9339</journal-id>
<journal-title><![CDATA[Odontoestomatología]]></journal-title>
<abbrev-journal-title><![CDATA[Odontoestomatología]]></abbrev-journal-title>
<issn>1688-9339</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Odontología - Universidad de la República]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1688-93392022000201316</article-id>
<article-id pub-id-type="doi">10.22592/ode2022n40e316</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Reabsorción ósea en la enfermedad periodontal: el papel de rank, rankl y opg. Una revisión de la bibliografía]]></article-title>
<article-title xml:lang="pt"><![CDATA[Reabsorção óssea na doença periodontal: o papel de rank, rankl e opg. Uma revisão da literatura]]></article-title>
<article-title xml:lang="en"><![CDATA[Bone resorption in periodontal disease: the role of RANK, RANKL and OPG. A literature review]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Asquino]]></surname>
<given-names><![CDATA[Natalia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vigil]]></surname>
<given-names><![CDATA[Gabriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pereira-Prado]]></surname>
<given-names><![CDATA[Vanesa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bueno Rossy]]></surname>
<given-names><![CDATA[Luis A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bologna-Molina]]></surname>
<given-names><![CDATA[Ronell]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de la República Facultad de Odontología Cátedra de Periodoncia]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de la República Facultad de Odontología Área de Patología Molecular Estomatológica]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<volume>24</volume>
<numero>40</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S1688-93392022000201316&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S1688-93392022000201316&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S1688-93392022000201316&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  La periodontitis es una de las enfermedades bucales de mayor prevalencia, el estudio de su patogénesis ha avanzado mucho en los últimos años, sin embargo, los detalles de los mecanismos involucrados en la reabsorción ósea no están aún esclarecidos. RANK, RANKL y OPG son proteínas que tienen un rol conocido en otras enfermedades del tejido óseo, en este trabajo se revisó la evidencia sobre su posible participación en la patogenia de la enfermedad periodontal. Es necesaria más evidencia para conocer la relación entre RANK, RANKL, OPG y la reabsorción ósea vinculada a la periodontitis.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo  A periodontite é uma das doenças bucais mais prevalentes, o estudo de sua patogênese avançou muito nos últimos anos, porém, os detalhes dos mecanismos envolvidos na reabsorção óssea ainda não estão esclarecidos. RANK, RANKL e OPG são proteínas que possuem papel conhecido em outras doenças do tecido ósseo, neste trabalho foram revisadas as evidências de sua possível participação na patogênese da doença periodontal. Mais evidências são necessárias para entender a relação entre RANK, RANKL, OPG e reabsorção óssea associada à periodontite.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Periodontitis is one of the most prevalent oral diseases. The study of its pathogenesis has significantly advanced in recent years. However, the details of the mechanisms involved in bone resorption are not clear yet. RANK, RANKL, and OPG are proteins that have a known role in other bone tissue diseases. This paper reviews the evidence of their potential participation in the pathogenesis of periodontal disease. More evidence is needed to understand the relationship between RANK, RANKL, OPG, and bone resorption in periodontitis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[enfermedad periodontal]]></kwd>
<kwd lng="es"><![CDATA[RANK]]></kwd>
<kwd lng="es"><![CDATA[RANKL]]></kwd>
<kwd lng="es"><![CDATA[OPG]]></kwd>
<kwd lng="pt"><![CDATA[doença periodontal]]></kwd>
<kwd lng="pt"><![CDATA[RANK]]></kwd>
<kwd lng="pt"><![CDATA[RANKL]]></kwd>
<kwd lng="pt"><![CDATA[OPG]]></kwd>
<kwd lng="en"><![CDATA[periodontal disease]]></kwd>
<kwd lng="en"><![CDATA[RANK]]></kwd>
<kwd lng="en"><![CDATA[RANKL]]></kwd>
<kwd lng="en"><![CDATA[OPG]]></kwd>
</kwd-group>
</article-meta>
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