<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1688-1249</journal-id>
<journal-title><![CDATA[Archivos de Pediatría del Uruguay]]></journal-title>
<abbrev-journal-title><![CDATA[Arch. Pediatr. Urug.]]></abbrev-journal-title>
<issn>1688-1249</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Uruguaya de Pediatría]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1688-12492026000101302</article-id>
<article-id pub-id-type="doi">10.31134/ap.97.1.7</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome de Cushing exógeno secundario a la administración de corticoides]]></article-title>
<article-title xml:lang="en"><![CDATA[Exogenous Cushing&#8217;s Syndrome secondary to corticosteroid administration]]></article-title>
<article-title xml:lang="pt"><![CDATA[Síndrome de Cushing exógena secundária à administração de corticoides]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[Miguel Ángel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vomero]]></surname>
<given-names><![CDATA[Alejandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Notejane]]></surname>
<given-names><![CDATA[Martín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Purtscher]]></surname>
<given-names><![CDATA[Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garafoni]]></surname>
<given-names><![CDATA[Federico]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Speranza]]></surname>
<given-names><![CDATA[Noelia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[Loreley]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,UDELAR Facultad de Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,UDELAR Facultad de Medicina Unidad Académica Pediatría B]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,UDELAR Facultad de Medicina Unidad Académica de Farmacología y Terapéutica]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,UDELAR Facultad de Medicina Unidad Académica de Farmacología y Terapéutica]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,UDELAR Facultad de Medicina Unidad Académica de Farmacología y Terapéutica]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,UDELAR Facultad de Medicina Unidad Académica Pediatría B]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2026</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2026</year>
</pub-date>
<volume>97</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S1688-12492026000101302&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S1688-12492026000101302&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S1688-12492026000101302&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción: el síndrome de Cushing (SC) es un trastorno endocrinológico caracterizado por niveles elevados y sostenidos de cortisol. En la infancia y adolescencia la causa más frecuente es la administración prolongada de corticoides.  Objetivos: describir el caso de un adolescente que presentaba un SC exógeno; analizar las dificultades en su diagnóstico inicial y reflexionar sobre la prescripción racional de glucocorticoides.  Caso clínico: 11 años, sexo masculino. Antecedente de alopecia areata en tratamiento con prednisona 30 mg/día desde hace cinco meses. Presenta aumento de peso de 15 kg, acompañado de cambios de humor. Instala una semana previo a la consulta poliuria, polidipsia y polifagia acompañada de dolor abdominal. Al examen se constataron elementos característicos de SC. Se realizó el descenso gradual de corticoides con una evolución favorable.  Discusión: el desarrollo del SC exógeno está relacionado con la administración prolongada de corticoides, lo que determina la alteración del eje hipotálamo-hipófisis-adrenal (HHA) con manifestaciones como obesidad central, facies de luna llena, hipertensión arterial, hiperglucemia y osteoporosis. Para minimizar el riesgo es fundamental un diagnóstico precoz, así como la implementación de estrategias para la reducción gradual y controlada de la dosis de corticoides, permitiendo la recuperación funcional del eje HHA.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Summary:  Introduction:  Cushing&#8217;s Syndrome (CS) is an endocrinological disorder characterized by elevated and sustained cortisol levels. In childhood and adolescence, it is the most common cause is corticosteroid prolonged administration.  Objectives:  to describe the case of an adolescent with exogenous CS; analyze the difficulties in its initial diagnosis; and reflect on the rational prescription of glucocorticoids.  Clinical case:  11-year-old male with a history of alopecia areata and treatment with prednisone 30 mg/day for 5 months. Weight gain of 15 kg, accompanied by mood swings, occurred. One week prior to consultation, the patient presented with polyuria, polydipsia, and polyphagia accompanied by abdominal pain. Examination revealed features characteristic of CS. The corticosteroids were gradually tapered, with favorable outcomes.  Discussion:  the development of exogenous CS is related to prolonged administration of corticosteroids, which leads to alterations in the hypothalamic-pituitary-adrenal (HPA) axis, with manifestations such as central obesity, moon-shaped facial features, high blood pressure, hyperglycemia, and osteoporosis. Early diagnosis is essential to minimize this risk, as well as the implementation of strategies for gradual and controlled of the corticosteroid dose, allowing for functional recovery of the HPA axis.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução:  a Síndrome de Cushing (SC) é um transtorno endocrinológico caracterizado por níveis elevados e sustentados de cortisol. Na infância e adolescência, a causa mais frequente é a administração prolongada de corticoides.  Objetivos:  descrever o caso de um adolescente que apresentava uma SC exógena; analisar as dificuldades no seu diagnóstico inicial; e refletir sobre a prescrição racional de glicocorticoides.  Caso Clínico:  paciente de 11 anos, sexo masculino. Antecedente de alopecia areata em tratamento com prednisona 30 mg/dia há 5 meses. Apresentou aumento de peso de 15 kg, acompanhado de alterações de humor. Uma semana antes da consulta, instalou poliúria, polidipsia e polifagia acompanhadas de dor abdominal. Ao exame, constataram-se elementos característicos de SC. Foi realizada a redução gradual dos corticoides com uma evolução favorável.  Discussão:  o desenvolvimento da SC exógena está relacionado com a administração prolongada de corticoides, o que determina a alteração do eixo hipotálamo-hipófise-adrenal (HHA), com manifestações como obesidade central, face em lua cheia, hipertensão arterial, hiperglicemia e osteoporose. Para minimizar o risco, o diagnóstico precoce é fundamental, bem como a implementação de estratégias para a redução gradual e controlada da dose do corticoide, permitindo a recuperação funcional do eixo HHA.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Síndrome de Cushing]]></kwd>
<kwd lng="es"><![CDATA[Corticoesteroides]]></kwd>
<kwd lng="es"><![CDATA[Adolescente]]></kwd>
<kwd lng="en"><![CDATA[Cushing Syndrome]]></kwd>
<kwd lng="en"><![CDATA[Corticosteroids]]></kwd>
<kwd lng="en"><![CDATA[Adolescent]]></kwd>
<kwd lng="pt"><![CDATA[Síndrome de Cushing]]></kwd>
<kwd lng="pt"><![CDATA[Corticoesteroides]]></kwd>
<kwd lng="pt"><![CDATA[Adolescente]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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