1688-1249 1688-1249 S1688-12492021000401812 10.31134/ap.92.s2.8 Uruguay 00 12 2021 00 12 2021 92 nspe2 1 Food and Drug Adninistration 2020 2 World Health Organization 2004 3 2014 2014 11 11 CD001831 4 2009 55 11 11 1081-3 5 2012 3 1 1 6 2018 9 3 3 7 2016 7 7 7 CD011914 8 2014 6 679-86 9 Food and Drug Administration 2018 10 HealthCanada 2021 11 2021