<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1688-1249</journal-id>
<journal-title><![CDATA[Archivos de Pediatría del Uruguay]]></journal-title>
<abbrev-journal-title><![CDATA[Arch. Pediatr. Urug.]]></abbrev-journal-title>
<issn>1688-1249</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Uruguaya de Pediatría]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1688-12492019000400195</article-id>
<article-id pub-id-type="doi">10.31134/ap.90.4.2</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Conocimiento de la prescripción de medicamentos off label en pediatría]]></article-title>
<article-title xml:lang="en"><![CDATA[Level of awareness of pediatric off-line drug prescription]]></article-title>
<article-title xml:lang="pt"><![CDATA[Nível de conhecimento da prescrição de medicamentos off label em pediatria]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zunino]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Assandri]]></surname>
<given-names><![CDATA[Robert]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cartategui]]></surname>
<given-names><![CDATA[Alejandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martorell]]></surname>
<given-names><![CDATA[Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Minetti]]></surname>
<given-names><![CDATA[Mariana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez]]></surname>
<given-names><![CDATA[Jimena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Giachetto]]></surname>
<given-names><![CDATA[Gustavo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,UDELAR Facultad de Medicina Clínica Pediátrica C]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,UDELAR Facultad de Medicina Ciclo Metodología 2. Dr. Medicina]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,UDELAR Facultad de Medicina Clínica Pediátrica C]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2019</year>
</pub-date>
<volume>90</volume>
<numero>4</numero>
<fpage>195</fpage>
<lpage>202</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S1688-12492019000400195&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S1688-12492019000400195&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S1688-12492019000400195&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: Se define prescripción de medicamentos off label como aquella que se realiza en condiciones distintas a las indicadas en la ficha técnica o prospecto y, por lo tanto, diferentes para las que fueron autorizados y registrados. Se desconoce el conocimiento que tienen los pediatras sobre este tema en nuestro medio.  Objetivo:  indagar sobre el conocimiento que tienen estudiantes de posgrado de Pediatría y pediatras sobre la prescripción off label.  Material y método:  encuesta anónima a posgrados de Pediatría y pediatras que desempeñan su actividad en el Centro Hospitalario Pereira Rossell, Asociación Española y Médica Uruguaya. Se indagó acerca del conocimiento del término off label, su definición y prácticas habituales de prescripción. Se seleccionaron cinco fármacos de prescripción frecuente con el fin de indagar sus usos fuera de prospecto.  Resultados:  se encuestaron 63 profesionales, 34 posgrados y 29 pediatras. Refirieron conocer el término off label 25 (40%), de éstos, 10 desconocían el significado del mismo. Lograron identificar los usos off label de adrenalina 18, domperidona 17, loratadina 13, omeprazol 8 y ondansetrón 8.  Conclusiones:  se puede observar que la mayoría de los encuestados no tiene el conocimiento suficiente acerca de esta práctica, pudiendo constituir un problema para su prescripción.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Summary: Off-label drug prescription involves prescribing drugs under different conditions from those described in packaging labels or inserts or to those under which they were originally authorized or registered. In Uruguay, we do not know the level of pediatricians&#8217; awareness about this issue.  Objective: to find out the level of awareness that pediatricians and pediatrics&#8217; postgraduate students have regarding off-label prescriptions.  Materials and methods: anonymous survey to pediatricians and pediatrics&#8217; postgraduate students from the Pereira Rossell Children Hospital, Médica Uruguaya and Asociación Española HMOs. We asked them about their understanding about the term off-label, its definition and habitual prescription practices. We selected five frequently prescribed drugs in order to research about their use outside the package insert.  Results: we surveyed 63 professionals, 34 postgraduates and 29 pediatricians. 25 of them (40%) stated that they were aware of the term off-label, thought 10 of them did not know what the term meant. 18 respondents identified off-label use of adrenaline, 17 of domperidone, 13 of loratadine, 8 of omeprazole and 8 of ondansetron.  Conclusions:  most of the respondents did not have enough awareness or knowledge regarding off-label practices, which can lead to prescription problems.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo: A prescrição de medicamentos off-label é aquela que é realizada em condições diferentes das indicadas na ficha técnica ou prospecto e, portanto, diferentes daquelas para as que os medicamentos foram originalmente ou autorizados e registrados. Não conhecemos o nível de conhecimento que os pediatras têm sobre o assunto em Uruguai.  Objetivo:  investigar o conhecimento que os pediatras e estudantes de pós-graduação em pediatria têm sobre a prescrição off-label.  Materiais e métodos:  pesquisa anónima realizada a pediatras e estudantes de pediatria que trabalham no CHPR, Associação Espanhola e na Médica Uruguaia. Lhes perguntamos sobre o seu conhecimento do termo off-label, sobre sua definição e práticas de prescrição habitual. Selecionamos cinco medicamentos de prescrição frequente e pesquisamos o seu uso fora do folheto informativo.  Resultados:  pesquisamos 63 médicos, 34 pós-graduandos e 29 pediatras. 25 (40%) referiram conhecer o termo off-label. Desses 25, 10 não sabiam o significado do mesmo. Eles conseguiram identificar usos off-label de: adrenalina 18, domperidona 17, loratadina 13, omeprazol 8 e ondansetrom 8.  Conclusões:  a maioria dos entrevistados não tinham suficiente conhecimento sobre esta prática, o que pode ser um problema no momento da prescrição.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Uso fuera de lo indicado]]></kwd>
<kwd lng="es"><![CDATA[Preparaciones farmacéuticas]]></kwd>
<kwd lng="es"><![CDATA[Prescripciones]]></kwd>
<kwd lng="es"><![CDATA[Pediatría.]]></kwd>
<kwd lng="en"><![CDATA[Off label use]]></kwd>
<kwd lng="en"><![CDATA[Pharmaceutical preparations]]></kwd>
<kwd lng="en"><![CDATA[Prescriptions]]></kwd>
<kwd lng="en"><![CDATA[Pediatrics]]></kwd>
<kwd lng="pt"><![CDATA[Uso off-label]]></kwd>
<kwd lng="pt"><![CDATA[Preparações farmacêuticas]]></kwd>
<kwd lng="pt"><![CDATA[Prescrições]]></kwd>
<kwd lng="pt"><![CDATA[Pediatria]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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