<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1688-0420</journal-id>
<journal-title><![CDATA[Revista Uruguaya de Cardiología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev.Urug.Cardiol.]]></abbrev-journal-title>
<issn>1688-0420</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Uruguaya de Cardiología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1688-04202025000101501</article-id>
<article-id pub-id-type="doi">10.29277/cardio.40.1.3</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Manejo práctico de los anticoagulantes directos]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Asadurian]]></surname>
<given-names><![CDATA[Pablo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Investigación y Ciencia en Hemostasis y Trombosis (ICHT)  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<volume>40</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S1688-04202025000101501&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S1688-04202025000101501&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S1688-04202025000101501&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El advenimiento de los nuevos anticoagulantes orales o anticoagulantes directos (DACO) y su creciente incorporación a la práctica clínica con apoyo en grandes estudios aleatorizados seminales de amplia difusión se transformó en una valiosa herramienta terapéutica y, a la vez, en un desafío para el médico práctico. Su uso apropiado requiere conocer, además de la información provista por dichos estudios, la historia clínica detallada del paciente, en especial la indicación de anticoagulación, su riesgo particular de sangrado y el impacto de circunstancias clínicas emergentes o potencialmente cambiantes que inciden en la propia indicación o en la continuidad del fármaco, así como en la dosis que debe emplearse. En este artículo y a propósito de un caso clínico se analiza el manejo práctico de los DACO durante procedimientos invasivos y cómo realizar la transición de un anticoagulante a otro. El uso adecuado de los DACO reduce complicaciones trombóticas y hemorrágicas y su manejo resulta más sencillo y seguro que el de la warfarina.]]></p></abstract>
</article-meta>
</front><back>
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