<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1688-0390</journal-id>
<journal-title><![CDATA[Revista Médica del Uruguay]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Méd. Urug.]]></abbrev-journal-title>
<issn>1688-0390</issn>
<publisher>
<publisher-name><![CDATA[Sindicato Médico del Uruguay]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1688-03902025000301206</article-id>
<article-id pub-id-type="doi">10.29193/rmu.41.3.6</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Estudio de interacciones farmacológicas en pacientes internados en un hospital universitario]]></article-title>
<article-title xml:lang="en"><![CDATA[Study of drug interactions in hospitalized patients at a university hospital]]></article-title>
<article-title xml:lang="pt"><![CDATA[Estudo de interações medicamentosas em pacientes internados em um hospital universitário]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quiroz]]></surname>
<given-names><![CDATA[Luca]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cuña]]></surname>
<given-names><![CDATA[Carolina Díaz]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vassallucci]]></surname>
<given-names><![CDATA[Ana Karenina]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Olmos]]></surname>
<given-names><![CDATA[Virginia]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bruno]]></surname>
<given-names><![CDATA[Gustavo]]></given-names>
</name>
</contrib>
</contrib-group>
<aff id="A">
<institution><![CDATA[,Hospital Maciel  ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<volume>41</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S1688-03902025000301206&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S1688-03902025000301206&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S1688-03902025000301206&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: las reacciones adversas a los medicamentos son una importante causa de morbimortalidad en los pacientes. Para prevenirlas es fundamental conocer las interacciones farmacológicas que pueden producirlas.  Objetivos: describir las interacciones fármaco-fármaco en una cohorte de pacientes ingresados en una sala de medicina de un hospital universitario.  Materiales y método: estudio descriptivo y transversal. Se evaluaron durante 2 meses las prescripciones de los pacientes y sus interacciones farmacológicas utilizando el programa informático Micromedex®. Se contemplaron las interacciones mayores y las contraindicaciones. Se relacionaron las interacciones con la edad, sexo, fármacos recibidos y días de internación.  Resultados: se incluyeron 57 pacientes. Se detectaron 109 interacciones mayores y 8 contraindicaciones en 24 pacientes (42% de los pacientes). Los pacientes con interacciones presentaron más días de internación (26,5 frente a 13,8, p=0,003), y mayor cantidad de fármacos recibidos por día (9 frente a 7,5, p=0,061). No se encontraron diferencias en edad ni sexo. Los fármacos involucrados de forma más frecuente fueron opioides, antipsicóticos, antitrombóticos, antidepresivos y benzodiacepinas. En el 58,1% de las interacciones participaron psicofármacos. Los potenciales efectos adversos más frecuentes fueron el riesgo de depresión del sistema nervioso central, prolongación del intervalo QT y riesgo de sangrado.  Conclusiones: las interacciones fármaco-fármaco son un problema frecuente en los pacientes internados. Formar equipos multidisciplinarios, conocer las interacciones y buscar los efectos adversos de forma activa es importante para la seguridad del paciente.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: adverse drug reactions are a major cause of morbidity and mortality in patients. Understanding drug interactions that may trigger these events is essential for prevention.  Objectives: to describe drug&#8211;drug interactions in a cohort of patients admitted to a medical ward in a university hospital.  Materials and methods: descriptive, cross-sectional study. Patient prescriptions and drug interactions were assessed over a 2-month period using the Micromedex® software. Major interactions and contraindications were analyzed. Associations were examined with age, sex, number of drugs prescribed, and length of hospital stay.  Results: a total of 57 patients were included. In 24 patients (42%), 109 major interactions and 8 contraindications were detected. Patients with interactions had longer hospital stays (26.5 vs 13.8 days, p=0.003) and received more medications per day (9 vs 7.5, p=0.061). No differences were found in age or sex. The most frequently involved drugs were opioids, antipsychotics, antithrombotics, antidepressants, and benzodiazepines. Psychotropic drugs were involved in 58.1% of interactions. The most common potential adverse effects were central nervous system depression, QT interval prolongation, and bleeding risk.  Conclusions: drug&#8211;drug interactions are a common issue among hospitalized patients. Building multidisciplinary teams, being aware of potential interactions, and actively monitoring for adverse effects are key to ensuring patient safety.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo  Introdução: as reações adversas a medicamentos são uma causa importante de morbimortalidade em pacientes. Conhecer as interações medicamentosas que podem causá-las é essencial para preveni-las.  Objetivos: descrever as interações entre medicamentos em uma coorte de pacientes internados em uma enfermaria de clínica médica de um hospital universitário.  Materiais e métodos: estudo descritivo e transversal. As prescrições dos pacientes e suas interações medicamentosas foram avaliadas durante 2 meses, utilizando o software Micromedex®. Foram consideradas as interações de maior gravidade e as contraindicações. As interações foram relacionadas à idade, sexo, número de medicamentos recebidos e tempo de internação.  Resultados: foram incluídos 57 pacientes. Em 24 deles (42%) foram detectadas 109 interações de maior gravidade e 8 contraindicações. Pacientes com interações tiveram tempo de internação mais longo (26,5 vs 13,8 dias, p=0,003) e receberam mais medicamentos por dia (9 vs 7,5, p=0,061). Não houve diferenças em relação à idade ou sexo. Os medicamentos mais frequentemente envolvidos foram opioides, antipsicóticos, antitrombóticos, antidepressivos e benzodiazepínicos. Psicofármacos participaram em 58,1% das interações. Os efeitos adversos potenciais mais comuns foram depressão do sistema nervoso central, prolongamento do intervalo QT e risco de sangramento.  Conclusões: as interações entre medicamentos são um problema frequente em pacientes hospitalizados. Formar equipes multidisciplinares, conhecer as interações e buscar ativamente os efeitos adversos é fundamental para a segurança do paciente.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Interacciones farmacológicas]]></kwd>
<kwd lng="es"><![CDATA[Seguridad del paciente]]></kwd>
<kwd lng="es"><![CDATA[Efectos adversos por drogas]]></kwd>
<kwd lng="es"><![CDATA[Farmacia intrahospitalaria]]></kwd>
<kwd lng="en"><![CDATA[Drug interactions]]></kwd>
<kwd lng="en"><![CDATA[Patient safety]]></kwd>
<kwd lng="en"><![CDATA[Drug-related adverse effects]]></kwd>
<kwd lng="en"><![CDATA[Inpatient pharmacy]]></kwd>
<kwd lng="pt"><![CDATA[Interações medicamentosas]]></kwd>
<kwd lng="pt"><![CDATA[Segurança do paciente]]></kwd>
<kwd lng="pt"><![CDATA[Efeitos adversos de medicamentos]]></kwd>
<kwd lng="pt"><![CDATA[Farmácia hospitalar]]></kwd>
</kwd-group>
</article-meta>
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