<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1688-0390</journal-id>
<journal-title><![CDATA[Revista Médica del Uruguay]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Méd. Urug.]]></abbrev-journal-title>
<issn>1688-0390</issn>
<publisher>
<publisher-name><![CDATA[Sindicato Médico del Uruguay]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1688-03902025000201701</article-id>
<article-id pub-id-type="doi">10.29193/rmu.41.2.3</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Orbitopatía asociada a hipotiroidismo: reporte de un caso y revisión de la literatura]]></article-title>
<article-title xml:lang="en"><![CDATA[Thyroid-associated orbitopathy in hypothyroidism: case report and literature review]]></article-title>
<article-title xml:lang="pt"><![CDATA[Orbitopatia associada ao hipotireoidismo: relato de caso e revisão da literatura]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Dorfman]]></surname>
<given-names><![CDATA[Florencia]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[Beatriz]]></given-names>
</name>
</contrib>
</contrib-group>
<aff id="A">
<institution><![CDATA[,Hospital de Clínicas Dr. Manuel Quintela  ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<volume>41</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S1688-03902025000201701&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S1688-03902025000201701&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S1688-03902025000201701&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La orbitopatía tiroidea es una enfermedad inflamatoria autoinmune órgano-específica que afecta el tejido conectivo retroocular, los músculos periorbitarios y la grasa retroorbitaria. Si bien se asocia predominantemente con hipertiroidismo por enfermedad de Graves-Basedow, también puede presentarse en pacientes con hipotiroidismo secundario a tiroiditis de Hashimoto, aunque con menor frecuencia. Presentamos el caso de un paciente con hipotiroidismo por tiroiditis de Hashimoto que desarrolló orbitopatía tiroidea. Se discuten los mecanismos fisiopatológicos, el cuadro clínico y el abordaje terapéutico basado en la evidencia disponible.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Thyroid-associated orbitopathy is an organ-specific autoimmune inflammatory disease affecting the retroocular connective tissue, periorbital muscles, and retroorbital fat. Although it is primarily associated with hyperthyroidism due to Graves&#8217; disease, it can also occur in patients with hypothyroidism secondary to Hashimoto&#8217;s thyroiditis, albeit less frequently. We present the case of a patient with hypothyroidism due to Hashimoto&#8217;s thyroiditis who developed thyroid orbitopathy. The pathophysiological mechanisms, clinical presentation, and evidence-based therapeutic approach are discussed.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo A orbitopatia tireoidiana é uma doença inflamatória autoimune órgão-específica que afeta o tecido conjuntivo retrocular, os músculos periorbitários e a gordura retroorbitária. Embora esteja principalmente associada ao hipertireoidismo causado pela doença de Graves-Basedow, também pode ocorrer em pacientes com hipotireoidismo secundário à tireoidite de Hashimoto, embora com menor frequência. Apresentamos o caso de um paciente com hipotireoidismo devido à tireoidite de Hashimoto que desenvolveu orbitopatia tireoidiana. Discutimos os mecanismos fisiopatológicos, a apresentação clínica e a abordagem terapêutica baseada em evidências disponíveis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Orbitopatía tiroidea]]></kwd>
<kwd lng="es"><![CDATA[Hipotiroidismo]]></kwd>
<kwd lng="es"><![CDATA[Tiroiditis de hashimoto]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad ocular tiroidea]]></kwd>
<kwd lng="es"><![CDATA[Autoinmunidad]]></kwd>
<kwd lng="en"><![CDATA[Thyroid orbitopathy]]></kwd>
<kwd lng="en"><![CDATA[Hypothyroidism]]></kwd>
<kwd lng="en"><![CDATA[Hashimoto&#8217;s thyroiditis]]></kwd>
<kwd lng="en"><![CDATA[Thyroid eye disease]]></kwd>
<kwd lng="en"><![CDATA[Autoimmunity]]></kwd>
<kwd lng="pt"><![CDATA[Orbitopatia tireoidiana]]></kwd>
<kwd lng="pt"><![CDATA[Hipotireoidismo]]></kwd>
<kwd lng="pt"><![CDATA[Tireoidite de hashimoto]]></kwd>
<kwd lng="pt"><![CDATA[Doença ocular tireoidiana]]></kwd>
<kwd lng="pt"><![CDATA[Autoimunidade]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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