<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1688-0390</journal-id>
<journal-title><![CDATA[Revista Médica del Uruguay]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Méd. Urug.]]></abbrev-journal-title>
<issn>1688-0390</issn>
<publisher>
<publisher-name><![CDATA[Sindicato Médico del Uruguay]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1688-03902023000201205</article-id>
<article-id pub-id-type="doi">1688-0390-rmu-39-2-e205</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Infecciones osteoarticulares: epidemiología, etiología y evolución clínica en un centro de referencia nacional]]></article-title>
<article-title xml:lang="en"><![CDATA[Osteoarticular infections: epidemiology, etiology and clinical evolution in a national reference center]]></article-title>
<article-title xml:lang="pt"><![CDATA[Infecções osteoarticulares: epidemiologia, etiologia e evolução clínica em um centro de referência nacional]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tenaglia]]></surname>
<given-names><![CDATA[Karina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sosa]]></surname>
<given-names><![CDATA[Alexis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Medina]]></surname>
<given-names><![CDATA[Julio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de la República. Facultad de Medicina Instituto Nacional de Ortopedia y Traumatología-Hospital de Clínicas. Unidad docente asistencial]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de la República Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de la República Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>39</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S1688-03902023000201205&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S1688-03902023000201205&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S1688-03902023000201205&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  la infección osteo-articular es una patología compleja, y su prevalencia esta en aumento. Conocer las principales características de su presentación clínica, etiología y evolución permite mejorar su abordaje.  Material y métodos: estudio observacional, retrospectivo, período 01 de enero 2020 a 31 diciembre 2020 en el Instituto Nacional de Ortopedia y Traumatología. Se incluyeron todos los pacientes adultos ingresados con diagnóstico clínico de infección osteo-articular y que fueron asistido en conjunto por Enfermedades Infecciosas y Traumatología en el período de estudio. Todos los casos contaban con uno o más cultivos microbiológicos profundos.  Resultados:  hubo 132 pacientes con infección osteo-articular, la relación hombre-mujer fue 2 a 1 y una media de 53 años. La presentación clínica fue con dolor, fístula y signos fluxivos locales. Las infecciones más frecuentes fueron de fracturas y prótesis articulares. El 54% de las infecciones fue por cocos gram positivos, 31% por enterobacterias y 13% bacilos gram negativos no fermentadores. En cuanto al perfil de sensibilidad 33% de los cocos fueron meticilino resistentes y 43% de las enterobacterias multirresistentes.  Conclusión: La patología mas frecuente en 2 de cada 3 ingresos fue la infección de fracturas y la asociada a material implantado. A la complejidad habitual del tratamiento quirúrgico y antimicrobiano de esta patología se suma que 3 de cada 10 microorganismos aislados fueron resistentes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  osteoarticular infections are a complex condition that are gradually increasing in prevalence. Learning about its clinical presentation, etiology and evolution will enable improving its management.  Method:  observational, retrospective study of cases seen at the National Orthopedic and Traumatology Institute from January 1st, 2020 to December 31st, 2020. All adult patients admitted with clinical diagnosis of osteoarticular infection who were assisted jointly by the Infectious Diseases and Traumatology units in the above mentioned period were included in the study. All cases had at least one deep microbiological cultures.  Results:  there were 132 patients with osteoarticular infection, female to male ratio was 2-to-1 and average age was 53 years old. Clinical presentation was characterized by pain, fistula and local fluxiye signs. The most frequent infections were fracture and prosthetic joint infections. Fifty four percent of infections were caused by gram-positive coccus, 31% were caused by enterobacteria and 13% by nonfermenting gram-negative bacilli (NFGNB). As to the sensitivity profile, 33% of cocci were methicillin-resistant and 43% of enterobacteria were multidrug-resistant.  Conclusions:  the most frequent pathology in 2 out of three hospitalizations were fracture infection and infections in orthopedic-related devices. The usual complexity.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução: a infecção osteoarticular é uma patologia complexa, e sua prevalência está aumentando. Conhecer as principais características da sua apresentação clínica, etiologia e evolução permite-nos melhorar a sua abordagem.  Material e métodos: estudo observacional, retrospectivo, que inclui pacientes atendidos no período 1º de janeiro -a 31 de dezembro de 2020 no Instituto Nacional de Ortopedia e Traumatologia. Foram incluídos todos os pacientes adultos internados com diagnóstico clínico de infecção osteoarticular atendidos conjuntamente por especialistas em Infecciologia e Traumatologia. Em todos os casos foram realizadas uma ou mais culturas microbiológicas profundas.  Resultados: foram incluídos 132 pacientes diagnosticados com infecção osteoarticular, a relação homem-mulher foi de 2 para 1 e a idade média foi 53 anos. A apresentação clínica foi: dor, fístula e sinais inflamatórios agudos locais. As infecções mais frequentes foram as associadas a fraturas e próteses articulares. 54% das infecções foram devidas a cocos Gram positivos, 31% a enterobactérias e 13% a bacilos Gram negativos não fermentadores. Em relação ao perfil de sensibilidade, 33% dos cocos eram resistentes à meticilina e 43% das enterobactérias eram multirresistentes.  Conclusão:  a patologia mais frequente em 2 dos 3 internamentos foi a infecção das fracturas e estava associada ao material implantado. Acrescenta-se à complexidade usual do tratamento cirúrgico e antimicrobiano desta doença o fato de que 3 em cada 10 microrganismos isolados eram resistentes.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Infección osteo-articular]]></kwd>
<kwd lng="es"><![CDATA[Osteomielitis]]></kwd>
<kwd lng="es"><![CDATA[Infecciones relacionadas con prótesis]]></kwd>
<kwd lng="en"><![CDATA[Osteo-articular infection]]></kwd>
<kwd lng="en"><![CDATA[Osteomyelitis]]></kwd>
<kwd lng="en"><![CDATA[Prosthesis-related infections]]></kwd>
<kwd lng="pt"><![CDATA[Infecção osteoarticular]]></kwd>
<kwd lng="pt"><![CDATA[Osteomielite]]></kwd>
<kwd lng="pt"><![CDATA[Infecções relacionadas à prótese]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Masters]]></surname>
<given-names><![CDATA[EA]]></given-names>
</name>
<name>
<surname><![CDATA[Ricciardi]]></surname>
<given-names><![CDATA[BF]]></given-names>
</name>
<name>
<surname><![CDATA[Bentley]]></surname>
<given-names><![CDATA[KLM]]></given-names>
</name>
<name>
<surname><![CDATA[Moriarty]]></surname>
<given-names><![CDATA[TF]]></given-names>
</name>
<name>
<surname><![CDATA[Schwarz]]></surname>
<given-names><![CDATA[EM]]></given-names>
</name>
<name>
<surname><![CDATA[Muthukrishnan]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Skeletal infections microbial pathogenesis, immunity and clinical management]]></article-title>
<source><![CDATA[Nat Rev Microbiol]]></source>
<year>2022</year>
<volume>20</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>385-400</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Walter]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Rupp]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Baertl]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Alt]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The role of multidisciplinary teams in musculoskeletal infection]]></article-title>
<source><![CDATA[Bone Joint Res]]></source>
<year>2022</year>
<volume>11</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>6-7</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ferry]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Seng]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Mainard]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Jenny]]></surname>
<given-names><![CDATA[JY]]></given-names>
</name>
<name>
<surname><![CDATA[Laurent]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Senneville]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The CRIOAc healthcare network in France a nationwide Health Ministry program to improve the management of bone and joint infection]]></article-title>
<source><![CDATA[Orthop Traumatol Surg Res]]></source>
<year>2019</year>
<volume>105</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>185-90</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="">
<collab>Fondo Nacional de Recursos</collab>
<source><![CDATA[Visualizador actos médicos 2020]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="">
<collab>Unidad Nacional de Seguridad Vial</collab>
<source><![CDATA[2021-Informe semestral de Siniestralidad Vial. Estadísticas]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Constant]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Calabro]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Metsemakers]]></surname>
<given-names><![CDATA[WJ]]></given-names>
</name>
<name>
<surname><![CDATA[Richards]]></surname>
<given-names><![CDATA[RG]]></given-names>
</name>
<name>
<surname><![CDATA[Moriarty]]></surname>
<given-names><![CDATA[TF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Preclinical models of Infection in Bone and Joint Surgery En: Zimmerli W, ed. Bone and Joint Infections: from microbiology to diagnostics and treatment. 2nd ed]]></article-title>
<source><![CDATA[John Wiley Sons,]]></source>
<year>2021</year>
<page-range>99-115</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Renz]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Margaryan]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Trampuz]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diagnostic approach in bone and joint infections En: Zimmerli W, ed. Bone and Joint Infections: from microbiology to diagnostics and treatment. 2nd ed]]></article-title>
<source><![CDATA[John Wiley Sons,]]></source>
<year>2021</year>
<page-range>5-20</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sendi]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Morgenstern]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Metsemakers]]></surname>
<given-names><![CDATA[WJ]]></given-names>
</name>
<name>
<surname><![CDATA[McNally]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fracture-related infection of the long bones En: Zimmerli W, ed. Bone and Joint Infections: from microbiology to diagnostics and treatment. 2nd ed]]></article-title>
<source><![CDATA[John Wiley Sons,]]></source>
<year>2021</year>
<page-range>367-85</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Karczewski]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Winkler]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Renz]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Trampuz]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Lieb]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Perka]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A standardized interdisciplinary algorithm for the treatment of prosthetic joint infections.]]></article-title>
<source><![CDATA[Bone Joint J]]></source>
<year>2019</year>
<volume>101-B</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>132-9</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ariza]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Cobo]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Baraia-Etxaburu]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Benito]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Bori]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Cabo]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Executive summary of management of prosthetic joint infections Clinical practice guidelines by the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC)]]></article-title>
<source><![CDATA[Enferm Infecc Microbiol Clin]]></source>
<year>2017</year>
<volume>35</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>189-95</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zimmerli]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Borens]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Infectious arthritis]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Peter]]></surname>
<given-names><![CDATA[E. Ochsner]]></given-names>
</name>
<name>
<surname><![CDATA[Borens]]></surname>
<given-names><![CDATA[Olivier]]></given-names>
</name>
<name>
<surname><![CDATA[Bodler]]></surname>
<given-names><![CDATA[Paul-Michael]]></given-names>
</name>
</person-group>
<source><![CDATA[Infections of the musculoskeletal system. Basic principles, prevention, diagnosis and treatment]]></source>
<year>2016</year>
<page-range>147-55</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ross]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Septic arthritis of native joints]]></article-title>
<source><![CDATA[Infect Dis Clin North Am]]></source>
<year>2017</year>
<volume>31</volume>
<page-range>203-18</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Metsemakers]]></surname>
<given-names><![CDATA[WJ]]></given-names>
</name>
<name>
<surname><![CDATA[Morgenstern]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[McNally]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Moriarty]]></surname>
<given-names><![CDATA[TF]]></given-names>
</name>
<name>
<surname><![CDATA[McFadyen]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Scarborough]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fracture-related infection a consensus on definition from an international expert group]]></article-title>
<source><![CDATA[Injury]]></source>
<year>2018</year>
<volume>49</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>505-10</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[McNally]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Sousa]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Wouthuyzen-Bakker]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[AF]]></given-names>
</name>
<name>
<surname><![CDATA[Soriano]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Vogely]]></surname>
<given-names><![CDATA[HC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The EBJIS definition of periprosthetic joint infection]]></article-title>
<source><![CDATA[Bone Joint J]]></source>
<year>2021</year>
<volume>103-B</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>18-25</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cardoso]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Barbosa]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Coelho]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<name>
<surname><![CDATA[Correia]]></surname>
<given-names><![CDATA[JG]]></given-names>
</name>
<name>
<surname><![CDATA[Maurício]]></surname>
<given-names><![CDATA[HL]]></given-names>
</name>
<name>
<surname><![CDATA[Lima]]></surname>
<given-names><![CDATA[Á]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Spondylodiscitis a retrospective analysis of clinical, etiological, and radiological diagnosis]]></article-title>
<source><![CDATA[Int J Spine Surg]]></source>
<year>2020</year>
<volume>14</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>226-31</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Magiorakos]]></surname>
<given-names><![CDATA[AP]]></given-names>
</name>
<name>
<surname><![CDATA[Srinivasan]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Carey]]></surname>
<given-names><![CDATA[RB]]></given-names>
</name>
<name>
<surname><![CDATA[Carmeli]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Falagas]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
<name>
<surname><![CDATA[Giske]]></surname>
<given-names><![CDATA[CG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria an international expert proposal for interim standard definitions for acquired resistance]]></article-title>
<source><![CDATA[Clin Microbiol Infect]]></source>
<year>2012</year>
<volume>18</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>268-81</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alberdi]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Atutxa]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Zabarte]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Epidemiología del trauma grave]]></article-title>
<collab>Grupo de Trabajo de Trauma y Neurointensivismo de SEMICYUC</collab>
<source><![CDATA[Med Intensiva]]></source>
<year>2014</year>
<volume>38</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>580-8</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Paolillo]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Scasso]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Torres]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Barrios]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Tavares]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Ahmed]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Siniestros de tránsito, los grupos relacionados por el diagnóstico y los costos hospitalarios. Características clínicas y costos de 740 pacientes hospitalizados por siniestros de tránsito en el trienio 2012- 2014 en La Asistencial Médica Departamental de Maldonado, Uruguay]]></article-title>
<source><![CDATA[Rev Méd Urug]]></source>
<year>2016</year>
<volume>32</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>25-35.</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Whitaker]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Denning]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Assessing trauma care health systems in low- and middle-income countries, a protocol for a systematic literature review and narrative synthesis]]></article-title>
<collab>O´Donohoe N.Poenaru D.Guadagno E.Leather A</collab>
<source><![CDATA[Syst Rev]]></source>
<year>2019</year>
<volume>8</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>157</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20.</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Parvizi]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Gehrke]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
</person-group>
<source><![CDATA[Proceedings of the Second International Consensus Meeting on Musculoskeletal Infection]]></source>
<year>2018</year>
<publisher-name><![CDATA[Philadelpia]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="book">
<source><![CDATA[Global guidelines for the prevention of surgical site infection,]]></source>
<year>2018</year>
<edition>2</edition>
<publisher-loc><![CDATA[Geneva ]]></publisher-loc>
<publisher-name><![CDATA[World Health Organization]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Parvizi]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Shohat]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Gehrke]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevention of periprosthetic joint infection: new guidelines]]></article-title>
<source><![CDATA[Bone Joint J]]></source>
<year>2017</year>
<volume>99-B</volume>
<numero>4_Suppl_ B</numero>
<issue>4_Suppl_ B</issue>
<page-range>3-10</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Garrote-Garrote]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Del-Moral-Luque]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Checa-García]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Valverde-Cánovas]]></surname>
<given-names><![CDATA[JF]]></given-names>
</name>
<name>
<surname><![CDATA[Campelo-Gutiérrez]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez-Martín]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antibioterapia profiláctica en la artroplastia de cadera Estudio de cohortes]]></article-title>
<source><![CDATA[Rev Esp Quimioter]]></source>
<year>2018</year>
<volume>31</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>118-22</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alamanda]]></surname>
<given-names><![CDATA[VK]]></given-names>
</name>
<name>
<surname><![CDATA[Springe]]></surname>
<given-names><![CDATA[BD.]]></given-names>
</name>
<name>
<surname><![CDATA[Bone Joint]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[The prevention of infection: 12 modifiable risk factors]]></source>
<year>2019</year>
<volume>101-B</volume>
<numero>1_Suppl_A</numero>
<issue>1_Suppl_A</issue>
<page-range>3-9</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[CY]]></given-names>
</name>
<name>
<surname><![CDATA[Hsieh]]></surname>
<given-names><![CDATA[RW]]></given-names>
</name>
<name>
<surname><![CDATA[Yen]]></surname>
<given-names><![CDATA[HT]]></given-names>
</name>
<name>
<surname><![CDATA[Hsu]]></surname>
<given-names><![CDATA[TC]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[CY]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[YC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Short- versus long-course antibiotics in osteomyelitis a systematicreview and meta-analysis]]></article-title>
<source><![CDATA[Int J Antimicrob Agents]]></source>
<year>2019</year>
<volume>53</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>246-60</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[HK]]></given-names>
</name>
<name>
<surname><![CDATA[Rombach]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Zambellas]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Walker]]></surname>
<given-names><![CDATA[AS]]></given-names>
</name>
<name>
<surname><![CDATA[McNally]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Atkins]]></surname>
<given-names><![CDATA[BL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Oral versus intravenous antibiotics for bone and joint infection]]></article-title>
<source><![CDATA[NEngl J Med]]></source>
<year>2019</year>
<volume>380</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>425-36</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chang]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Bhandari]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Zhu]]></surname>
<given-names><![CDATA[KL]]></given-names>
</name>
<name>
<surname><![CDATA[Mirza]]></surname>
<given-names><![CDATA[RD]]></given-names>
</name>
<name>
<surname><![CDATA[Ren]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Kennedy]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antibiotic prophylaxis in the management of open fractures: asystematic survey of current practice and recommendations.]]></article-title>
<source><![CDATA[JBJS Rev]]></source>
<year>2019</year>
<volume>7</volume>
<numero>2:e1</numero>
<issue>2:e1</issue>
</nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fantoni]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Taccari]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Giovannenze]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Systemic antibiotic treatment of chronic osteomyelitis in adults]]></article-title>
<source><![CDATA[Eur Rev Med Pharmacol Sci]]></source>
<year>2019</year>
<volume>23</volume>
<numero>2 Suppl</numero>
<issue>2 Suppl</issue>
<page-range>258-70</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Glaudemans]]></surname>
<given-names><![CDATA[AWJM]]></given-names>
</name>
<name>
<surname><![CDATA[Jutte]]></surname>
<given-names><![CDATA[PC]]></given-names>
</name>
<name>
<surname><![CDATA[Cataldo]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Cassar-Pullicino]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Gheysens]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Borens]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Consensus document for the diagnosis of peripheral bone infection in adults: a joint paper by the EANM, EBJIS, and ESR (with ESCMID endorsement).]]></article-title>
<source><![CDATA[Eur J Nucl Med Mol Imaging]]></source>
<year>2019</year>
<volume>46</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>957-70</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vemu]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Sudhaharan]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Mamidi]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Chavali]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Need for appropriate specimen for microbiology diagnosis of chronic osteomyelitis]]></article-title>
<source><![CDATA[J Lab Physicians]]></source>
<year>2018</year>
<volume>10</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>21-5</page-range></nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kavanagh]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Ryan]]></surname>
<given-names><![CDATA[EJ]]></given-names>
</name>
<name>
<surname><![CDATA[Widaa]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Sexton]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Fennell]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Staphylococcal osteomyelitis disease progression, treatment challenges, and future directions]]></article-title>
<collab>O´Rourke S</collab>
<source><![CDATA[Clin Microbiol Rev]]></source>
<year>2018</year>
<volume>31</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>e00084-17</page-range></nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carvalho]]></surname>
<given-names><![CDATA[VC]]></given-names>
</name>
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[PR]]></given-names>
</name>
<name>
<surname><![CDATA[Dal-Paz]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Paula]]></surname>
<given-names><![CDATA[AP]]></given-names>
</name>
<name>
<surname><![CDATA[Félix Cda]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Lima]]></surname>
<given-names><![CDATA[AL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Gram-negative osteomyelitis clinical and microbiological profile]]></article-title>
<source><![CDATA[Braz J Infect Dis]]></source>
<year>2012</year>
<volume>16</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>63-7</page-range></nlm-citation>
</ref>
<ref id="B33">
<label>33</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Triffault-Fillit]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Ferry]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Laurent]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Pradat]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Dupieux]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Conrad]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Microbiologic epidemiology depending on time to occurrence of prosthetic joint infection a prospective cohort study]]></article-title>
<source><![CDATA[Clin Microbiol Infect]]></source>
<year>2019</year>
<volume>25</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>353-8</page-range></nlm-citation>
</ref>
<ref id="B34">
<label>34</label><nlm-citation citation-type="journal">
<collab>García del Pozo E.Collazos J.Carton JA.Camporro D.Asensi V</collab>
<article-title xml:lang=""><![CDATA[Factors predictive of relapse in adult bacterial osteomyelitis of long bones]]></article-title>
<source><![CDATA[BMC Infect Dis]]></source>
<year>2018</year>
<volume>18</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>635</page-range></nlm-citation>
</ref>
<ref id="B35">
<label>35</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Papadopoulos]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ribera]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Mavrogenis]]></surname>
<given-names><![CDATA[AF]]></given-names>
</name>
<name>
<surname><![CDATA[Rodriguez-Pardo]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Bonnet]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Salles]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Multidrug-resistant and extensively drug-resistant Gram-negative prosthetic joint infections role of surgery and impact of colistin administration]]></article-title>
<source><![CDATA[Int J Antimicrob Agents]]></source>
<year>2019</year>
<volume>53</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>294-301</page-range></nlm-citation>
</ref>
<ref id="B36">
<label>36</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pfang]]></surname>
<given-names><![CDATA[BG]]></given-names>
</name>
<name>
<surname><![CDATA[García-Cañete]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[García-Lasheras]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Blanco]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Auñón]]></surname>
<given-names><![CDATA[Á]]></given-names>
</name>
<name>
<surname><![CDATA[Parron-Cambero]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Orthopedic implant-associated infection by multidrug resistant enterobacteriaceae]]></article-title>
<source><![CDATA[J Clin Med]]></source>
<year>2019</year>
<volume>8</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>220</page-range></nlm-citation>
</ref>
<ref id="B37">
<label>37</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Antony]]></surname>
<given-names><![CDATA[SJ]]></given-names>
</name>
<name>
<surname><![CDATA[Parikh]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
<name>
<surname><![CDATA[Soto]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Cameron]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Mody]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Extended-spectrum beta-lactamase infections in orthopedic-related devices and prosthetic joints]]></article-title>
<source><![CDATA[Orthopedics]]></source>
<year>2016</year>
<volume>39</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>e668-73</page-range></nlm-citation>
</ref>
<ref id="B38">
<label>38</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Davido]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Saleh-Mghir]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Rottman]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Jaffal]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Salomon]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Bouchand]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Native bone and joint infections caused by extended-spectrumß-lactamase-producing Enterobacterales experience of a reference centre in the Greater Paris area]]></article-title>
<source><![CDATA[Int J Antimicrobial Agents]]></source>
<year>2022</year>
<volume>59</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>106497</page-range></nlm-citation>
</ref>
<ref id="B39">
<label>39</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pouderoux]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Becker]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Goutelle]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Lustig]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Triffault-Fillit]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Daoud]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Subcutaneous suppressive antibiotic therapy for bone and joint infections safety and outcome in a cohort of 10 patients]]></article-title>
<source><![CDATA[J Antimicrob Chemother]]></source>
<year>2019</year>
<volume>74</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>2060-4</page-range></nlm-citation>
</ref>
<ref id="B40">
<label>40</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[PR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Outpatient parenteral antimicrobial therapy for orthopedic infections - a successful public health care experience in Brazil]]></article-title>
<collab>da Silva Felix C.Cordeiro de Carvalho V.Mazzini Giovani A.Suarti dos Reis R.Beraldo M</collab>
<source><![CDATA[Braz J Infect Dis]]></source>
<year>2016</year>
<volume>20</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>272-5</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
