<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1688-0390</journal-id>
<journal-title><![CDATA[Revista Médica del Uruguay]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Méd. Urug.]]></abbrev-journal-title>
<issn>1688-0390</issn>
<publisher>
<publisher-name><![CDATA[Sindicato Médico del Uruguay]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1688-03902021000401204</article-id>
<article-id pub-id-type="doi">10.29193/rmu.37.4.4</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Caracterización de pacientes con microcarcinoma papilar de tiroides en el Hospital de Clínicas (UDELAR) en los últimos 10 años]]></article-title>
<article-title xml:lang="en"><![CDATA[Characterization of patients with papillary thyroid microcarcinoma at the Clinicas University Hospital (UDELAR) in the last 10 years]]></article-title>
<article-title xml:lang="pt"><![CDATA[Caracterização de pacientes com microcarcinoma papilar de tireoide no Hospital de Clínicas (UDELAR) nos últimos 10 anos]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mintegui]]></surname>
<given-names><![CDATA[Gabriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Casamayou]]></surname>
<given-names><![CDATA[Florencia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arciénega]]></surname>
<given-names><![CDATA[Claudia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[Beatriz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ronco]]></surname>
<given-names><![CDATA[Alvaro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de la República Hospital de Clínicas Facultad de Medicina]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de la República Hospital de Clínicas Facultad de Medicina]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de la República Hospital de Clínicas Facultad de Medicina]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,CLAEH Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Maldonado ]]></addr-line>
<country>Uruguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>37</volume>
<numero>4</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S1688-03902021000401204&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S1688-03902021000401204&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S1688-03902021000401204&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción: el microcarcinoma papilar tiroideo (MCPT) es un tumor &lt;1 cm, indolente y con diagnóstico incidental o asintomático. Su incidencia aumentó últimamente por mayor detección ecográfica de nódulos no palpables, pero la mortalidad se mantiene estable, con elevada sobrevida a largo plazo.  Objetivo:  caracterizar los pacientes con MCPT en la clínica de Endocrinología y Metabolismo del Hospital de Clínicas en la década 2008-2018.  Materiales y métodos:  estudio observacional, transversal, retrospectivo y analítico. Se revisaron historias de archivo y policlínica de pacientes que concurrieron a nuestro servicio desde junio/2008 a junio/2018. Se recabó el número de pacientes atendidos en el hospital en 1978-2008 para estimar incidencia y casuística anual. Las asociaciones entre variables y de tendencias se analizaron estadísticamente.  Resultados:  de 193 pacientes con carcinoma diferenciado de tiroides, 42 (22%) tuvieron MCPT. La incidencia hospitalaria de MCPT tendió a aumentar en los últimos 40 años (media = 4,2 casos/año); 88% fueron mujeres. El 69% de los diagnósticos fue por punción aspiración de aguja fina (PAAF) de un nódulo tiroideo, siendo 57% unifocales y 43% multifocales. Hubo asociación significativa entre multifocalidad e invasión capsular. Un 84% no tuvo metástasis ganglionares. En 55% de los casos se realizó radioyodo (RY) postcirugía.  Conclusiones:  aumentó la incidencia de MCPT, mayormente en mujeres. El diagnóstico prequirúrgico se hizo fundamentalmente por PAAF de nódulos tiroideos. La invasión capsular se asoció a multifocalidad. Un 16% tuvo metástasis ganglionares al diagnóstico. En la mayoría se realizó tiroidectomía total y 55% RY.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  papillary thyroid microcarcima (PTMC) is a tumour &lt;1 cm in size, indolent and with incidental or asymptomatic diagnostic. Recently, the incidence of PTMC increased as a result of higher ultrasound detection of nonpalpable nodes, although mortality rates remain stable, with high survival in the long-term.  Objective:  to characterize patients with PTMC at the Endocrinology and Metabolism Department of the Clinicas University Hospital in the 2008-2018 decade.  Method:  observational, transversal, retrospective and analytical study. Medical records filed and policlinic records of patients who were seen in our service since June, 2008 and June, 2018 were reviewed. The number of patients assisted in the hospital between 1978 and 2008 was found, to estimate incidence and annual casuistic. Statistical analysis of variables and tendencies was performed.  Results:  42 (22%) out of 139 patients with poorly differentiated thyroid carcinoma (PDTC) had papillary thyroid microcarcinoma. In the last 40 years, hospital incidence of PTMC has increased (average = 4,2 cases/year), 88% of which were female patients. 69% of diagnostics were done by thyroid fine-needle aspirate cytology (FNAC); 57% were single focal and 43% multifocal. There was a significant association between multifocality and capsule invasion. 84% of cases did not evidence lymph node metastases. In 55% of cases postoperative radioactive iodine therapy was applied.  Conclusions:  the incidence of PTMC increased, mainly in women. Diagnosis prior to surgery was mainly done by thyroid FNAC. Capsular invasion was associated to multifocality. 16% evidence lymph node metastases upon diagnosis. Complete thyroidectomy was done in most cases, followed by radioactive iodine therapy un 55% of cases.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução:  o microcarcinoma papilar de tireoide (MCPT) é um tumor &lt;1 cm, indolente e com diagnóstico incidental ou assintomático. Sua incidência aumentou recentemente devido à maior detecção ultrassonográfica de nódulos não palpáveis, mas a mortalidade permanece estável, com alta sobrevida em longo prazo.  Objetivo:  caracterizar os pacientes com MCPT no ambulatório de Endocrinologia e Metabolismo do Hospital de Clínicas na década de 2008-2018.  Materiais e métodos: estudo observacional, transversal, retrospectivo e analítico. Os prontuários de pacientes, históricos e atuais de pacientes foram atendidos no período junho 2008 - junho 2018 foram revisados. O número de pacientes tratados no hospital em 1978-2008 foi coletado para estimar a incidência e a casuística anual. As associações entre variáveis, e tendências foram analisadas estatisticamente.  Resultados: de 193 pacientes com carcinoma diferenciado de tireoide, 42 (22%) tinham MCPT. A incidência hospitalar de MCPT mostrou uma tendência crescente nos últimos 40 anos (média = 4,2 casos/ano); 88% eram mulheres. 69% dos diagnósticos foram realizados por punção aspirativa por agulha fina (PAAF) de nódulo tireoidiano, sendo 57% unifocal e 43% multifocal. Houve uma associação significativa entre multifocalidade e invasão capsular. 84% não apresentavam metástases em linfonodos. O radioiodo pós-operatório (RY) foi realizado em 55% dos casos.  Conclusões: a incidência de MCPT aumentou, principalmente em mulheres. O diagnóstico pré-cirúrgico foi feito principalmente pela PAAF de nódulos tireoidianos. A invasão capsular foi associada à multifocalidade. 16% tinham metástases linfonodais no momento do diagnóstico. Realizou-se tireoidectomia total na maioria dos pacientes e 55% foi submetida a RY.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Microcarcinoma papilar de tiroides.]]></kwd>
<kwd lng="en"><![CDATA[Papillary thyroid microcarcinoma.]]></kwd>
<kwd lng="pt"><![CDATA[Microcarcinoma papilar de tireoide.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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