<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1688-0390</journal-id>
<journal-title><![CDATA[Revista Médica del Uruguay]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Méd. Urug.]]></abbrev-journal-title>
<issn>1688-0390</issn>
<publisher>
<publisher-name><![CDATA[Sindicato Médico del Uruguay]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1688-03902018000100042</article-id>
<article-id pub-id-type="doi">10.29193/rmu.34.1.2</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Cáncer de cabeza y cuello en Uruguay. Análisis de sobrevida en dos centros de referencia]]></article-title>
<article-title xml:lang="en"><![CDATA[Head and neck cancer in Uruguay. Survival analysis in two reference centers]]></article-title>
<article-title xml:lang="pt"><![CDATA[Câncer de cabeça e pescoço no Uruguai. Análise de sobrevivência em dois centros de referência]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Álvarez Arias]]></surname>
<given-names><![CDATA[Diego]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Munyo Estefan]]></surname>
<given-names><![CDATA[Andrés]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Borche]]></surname>
<given-names><![CDATA[German]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[D&#8217;Albora]]></surname>
<given-names><![CDATA[Ricardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Sande]]></surname>
<given-names><![CDATA[Virginia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cuello]]></surname>
<given-names><![CDATA[Mauricio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de la República Hospital de Clínicas Cátedra de Otorrinolaringología]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de la República Hospital de Clínicas Cátedra de Otorrinolaringología]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de la República Hospital de Clínicas Cátedra de Otorrinolaringología]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de la República Hospital de Clínicas ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad de la República Hospital de Clínicas ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2018</year>
</pub-date>
<volume>34</volume>
<numero>1</numero>
<fpage>42</fpage>
<lpage>63</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S1688-03902018000100042&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S1688-03902018000100042&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S1688-03902018000100042&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  el carcinoma escamoso de cabeza y cuello (HNSCC) es el cáncer de mayor prevalencia en la otorrinolaringología, ocupando en el Uruguay el quinto lugar en incidencia y el sexto lugar en mortalidad en hombres. El propósito de este estudio fue analizar la sobrevida global de pacientes con cáncer de cabeza y cuello en dos centros de referencia de Montevideo.  Método:  se analizó de forma retrospectiva la sobrevida global de 436 pacientes diagnosticados con HNSCC entre los años 2005 y 2015. Se analizó la sobrevida por método de Kaplan-Meier en relación con el estadio tumoral, topografía, estatus de tabaquismo y alcoholismo de los pacientes. Para el estudio de la interacción de las variables con posible importancia en el pronóstico se utilizó el modelo de regresión de Cox.  Resultados:  la mediana de sobrevida global de los pacientes con cáncer de cabeza y cuello en nuestra serie es de 35,8 meses (23,5-48,1, IC 95%), para el cáncer de laringe fue superior a la del resto de los pacientes con cáncer de otros sitios anatómicos, 77,3 (49,3-105,2, IC 95%) versus 26,2 meses (20,7-48,1, IC 95%, p &lt; 0,001). No hubo diferencia entre la sobrevida global de tabaquistas y no tabaquistas. El grupo de los no alcoholistas presentó una mejor sobrevida global que el grupo de los alcoholistas, 72,4 (39,1-105,7, IC 95%) versus 26,7 (19,9-33,6 IC 95%). El análisis multivariante identificó el estadio y el alcoholismo como factores pronósticos independientes en nuestra serie.  Conclusiones:  la mediana de sobrevida global de nuestra serie es similar a la reportada en la bibliografía internacional. Los pacientes con cáncer de laringe presentan mayor sobrevida que los pacientes con cáncer de otros sitios otorrinolaringológicos. De los factores de riesgo clásicos, en nuestra serie el consumo de alcohol impacta negativamente en sobrevida de los pacientes con cáncer de cabeza y cuello.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction: head and neck squamous cell carcinomas (HNSCC) is the most prevalent cancer in otorhinolaryngology, being it the fifth cancer in terms of incidence in Uruguay and the sixth in male mortality. The study aims at analysing global survival in patients with head and neck cancer in two reference centers in Montevideo.  Method:  retrospective analysis of global survival of 436 patients diagnosed with HNSCC between 2005 and 2015. Survival was analysed with the Kaplan-Meier method with regard to the patients&#8217; stage of cancer, topography, smoking and alcohol consumption. The Cox regression method was used to study the interaction of variables with potential importance in the prognosis.  Results:  in our series median global survival of patients with head and neck cancer is 35.8 months (23.5-48.1, CI 95%), it as higher for larynx cancer than that of the rest of the patients with cancer in other anatomic sites, 77.3 (49.4-105.2, CI 95%) versus 26.2 months (20.7 - 48.1, CI 95%, p &lt; 0,001). There was no difference between the global survival of smokers and non-smokers. Non-alcohol consumers presented a better global survival than the group of alcohol consumers, 72.4 (39.1-105.7, CI 95%) versus 26.7 (19.9-33.6 CI 95%). The multivariable analysis identified stage of cancer and alcohol consumption as independent prognostic factors in our series.  Conclusions: median global survival in our series is similar to that reported in the international bibliography. Patients with larynx cancer evidence a longer survival than patients with cancer in other otorhinolaryngologic sites. As to classic risk factors, alcohol consumption has a negative impact on the survival of patients with head and neck cancer.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução: o carcinoma epidermóide de cabeça e pescoço (HNSCC) é o câncer com maior prevalência em Otorrinolaringologia; no Uruguai é o quinto tumor em incidência e o sexto em mortalidade em homens. O objetivo deste estudo foi analisar a sobrevida global dos pacientes com câncer de cabeça e pescoço em dois centros de referência de Montevidéu.  Métodos: fez-se uma análise retrospectiva da sobrevida global de 436 pacientes diagnosticados com HNSCC no período 2005-2015. A sobrevida foi estudada pelo método de Kaplan-Meier em relação ao estádio tumoral, topografia, estatus de tabaquismo e alcoolismo dos pacientes. Para estudar a interação das variáveis com possível importância no prognóstico utilizou-se o modelo de regressão de Cox.  Resultados: a mediana de sobrevida global dos pacientes com câncer de cabeça e pescoço na nossa serie foi de 35,8 meses (23,5-48,1, IC 95%), sendo superior para o câncer de laringe ao do resto dos pacientes com câncer de outros sítios anatômicos, 77,3 (49,3-105,2, IC 95%) versus 26,2 meses (20,7-48,1, IC 95%, p &lt; 0,001). Não se observou diferença entre a sobrevida global de fumantes e não fumantes. O grupo dos não alcoolistas apresentou uma melhor sobrevida global que o grupo dos alcoolistas, 72,4 (39,1-105,7, IC 95%) versus 26,7 (19,9-33,6 IC 95%). A análise multivariante identificou o estádio e o alcoolismo como fatores prognósticos independentes na nossa serie.  Conclusões: a mediana de sobrevida global da nossa serie é similar à descrita na bibliografia internacional. Os pacientes com câncer de laringe apresentam maior sobrevida que os pacientes com câncer de outros sítios otorrinolaringológicos. Dos fatores de risco clássicos, na nossa serie o consumo de álcool impacta negativamente na sobrevida dos pacientes com câncer de cabeça e pescoço.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Neoplasias de cabeza y cuello]]></kwd>
<kwd lng="es"><![CDATA[Tabaquismo]]></kwd>
<kwd lng="es"><![CDATA[Alcoholismo]]></kwd>
<kwd lng="es"><![CDATA[Sobrevida]]></kwd>
<kwd lng="es"><![CDATA[Uruguay]]></kwd>
<kwd lng="en"><![CDATA[Head and neck neoplasms]]></kwd>
<kwd lng="en"><![CDATA[Tobacco use disorder]]></kwd>
<kwd lng="en"><![CDATA[Alcoholism]]></kwd>
<kwd lng="en"><![CDATA[Survivorship]]></kwd>
<kwd lng="en"><![CDATA[Uruguay]]></kwd>
<kwd lng="pt"><![CDATA[Neoplasias de cabeça e pescoço]]></kwd>
<kwd lng="pt"><![CDATA[Tabagismo]]></kwd>
<kwd lng="pt"><![CDATA[Alcoolismo]]></kwd>
<kwd lng="pt"><![CDATA[Sobrevida]]></kwd>
<kwd lng="pt"><![CDATA[Uruguai]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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