<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0717-5000</journal-id>
<journal-title><![CDATA[CLEI Electronic Journal]]></journal-title>
<abbrev-journal-title><![CDATA[CLEIej]]></abbrev-journal-title>
<issn>0717-5000</issn>
<publisher>
<publisher-name><![CDATA[Centro Latinoamericano de Estudios en Informática]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0717-50002016000300058</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[How to deal with Haplotype data: An Extension to the Conceptual Schema of the Human Genome]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes Román]]></surname>
<given-names><![CDATA[José Fabián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pastor]]></surname>
<given-names><![CDATA[Óscar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valverde]]></surname>
<given-names><![CDATA[Francisco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Roldán M.]]></surname>
<given-names><![CDATA[David]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,PROS Research Center Universitat Politècnica de València ]]></institution>
<addr-line><![CDATA[Valencia ]]></addr-line>
<country>Spain</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Central del Este (UCE). Department of Engineering Sciences ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universitat de València Escola Tècnica Superior d'Enginyeria Departament d&#8217;Informàtica]]></institution>
<addr-line><![CDATA[Valencia ]]></addr-line>
<country>Spain</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2016</year>
</pub-date>
<volume>19</volume>
<numero>3</numero>
<fpage>58</fpage>
<lpage>106</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S0717-50002016000300058&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S0717-50002016000300058&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S0717-50002016000300058&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: The goal of this work is to describe the advantages of the application of Conceptual Modeling (CM) in complex domains, such as genomics. Nowadays, the study and comprehension of the human genome is a major challenge due to its high level of complexity. The constant evolution in the genomic domain contributes to the generation of ever larger amounts of new data, which means that if we do not manage it correctly data quality could be compromised (i.e., problems related with heterogeneity and inconsistent data). In this paper, we propose the use of a Conceptual Schema of the Human Genome (CSHG), designed to understand and improve our ontological commitment to the domain and also extend (enrich) this schema with the integration of a novel concept: Haplotypes. Our focus is on improving the understanding of the relationship between genotype and phenotype, since new findings show that this question is more complex than was originally thought. Here we present the first steps in our data management approach with haplotypes (variations, frequencies and populations) and discuss the database evolution to support this data. Each new version in our conceptual schema (CS) introduces changes to the underlying database structure that has essential and practical implications for better understanding and managing the relevant information. A solution based on conceptual models gives a clear definition of the domain with direct implications in the medical field (Precision Medicine), in which Genomic Information Systems (GeIS) play a very important role.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[haplotypes]]></kwd>
<kwd lng="en"><![CDATA[conceptual modeling]]></kwd>
<kwd lng="en"><![CDATA[GeIS]]></kwd>
<kwd lng="en"><![CDATA[statistical models]]></kwd>
<kwd lng="en"><![CDATA[genetic diagnosis.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Paton]]></surname>
<given-names><![CDATA[N. W.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8220;Conceptual Modelling of Genomic Information&#8221;]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Khan]]></surname>
<given-names><![CDATA[S. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Hayes]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Moussouni]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Brass]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Eillbeck]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Oliver]]></surname>
<given-names><![CDATA[S. G]]></given-names>
</name>
</person-group>
<source><![CDATA[BIOINFORMATICS]]></source>
<year>2000</year>
<volume>16</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>548-57</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="confpro">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pastor]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<source><![CDATA[Enforcing Conceptual Modeling to Improve the Understanding of Human Genome]]></source>
<year>2010</year>
<conf-name><![CDATA[ Asia-Pacific Conference on Conceptual Modelling]]></conf-name>
<conf-loc> </conf-loc>
</nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bornberg-Bauer]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8220;Conceptual data modelling for bioinformatics&#8221;]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Paton]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<source><![CDATA[Briefings in Bioinformatics]]></source>
<year>2002</year>
<volume>3</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>166-80</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="confpro">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martin]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Integrating Human Genome Variation Data: An Information System Approach]]></source>
<year>2011</year>
<conf-name><![CDATA[ 22nd International Workshop on Database and Expert Systems Applications (DEXA)]]></conf-name>
<conf-loc> </conf-loc>
</nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[&#8220;Sensibilidad al Alcohol y la Predisposición a beber&#8221;]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[A. M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Ciencia al Día Internacional]]></source>
<year>2000</year>
<volume>3</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>1-13</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dick]]></surname>
<given-names><![CDATA[D. M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8220;Candidate Genes for Alcohol Dependence: A Review of Genetic Evidence from Human Studies&#8221;]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Foroud]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<source><![CDATA[Clinical &amp; Experimental Research]]></source>
<year>2003</year>
<volume>27</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>868-79</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[P. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Ladero Quesada]]></surname>
<given-names><![CDATA[J. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Leza Cerro]]></surname>
<given-names><![CDATA[J. C.]]></given-names>
</name>
<name>
<surname><![CDATA[Lizasoain]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<source><![CDATA[Drogodependencias: Farmacología - Patología - Psicología - Legislación]]></source>
<year>2009</year>
<edition>3</edition>
<publisher-name><![CDATA[Médica Panamericana]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[&#8220;Integración de Haplotipos al Modelo Conceptual del Genoma Humano utilizando la Metodología SILE&#8221;]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reyes Román]]></surname>
<given-names><![CDATA[J. F.]]></given-names>
</name>
</person-group>
<source><![CDATA[Ing. Software, Métodos Formales &amp; Sistemas de Información]]></source>
<year>2013</year>
</nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Campos]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8220;Análisis del haplotipo en portadores de la mutación 6857delAA en el gen BRCA2 en 4 familias con cáncer de mama u ovario hereditario&#8221;]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Díez]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Álvarez]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Palma]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Domènech]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Balmaña]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Baiget]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Medicina Clínica]]></source>
<year>2004</year>
<volume>123</volume>
<numero>14</numero>
<issue>14</issue>
<page-range>543-5</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Álvarez]]></surname>
<given-names><![CDATA[A. S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8220;Asociación del cáncer de mama con los polimorfismos T-66G y G-156GG del gen SPP1 y las concentraciones séricas de osteopontina&#8221;]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Márquez]]></surname>
<given-names><![CDATA[J. T.]]></given-names>
</name>
<name>
<surname><![CDATA[Vargas]]></surname>
<given-names><![CDATA[F. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Romero]]></surname>
<given-names><![CDATA[M. R.]]></given-names>
</name>
</person-group>
<source><![CDATA[Ginecol Obstet Mex]]></source>
<year>2012</year>
<volume>80</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>22-9</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="">
<source><![CDATA[The Effects of Alcohol on the Brain]]></source>
<year>2016</year>
</nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Edenberg]]></surname>
<given-names><![CDATA[H. J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8220;Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations&#8221;]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Dick]]></surname>
<given-names><![CDATA[D. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Xuei]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Tian]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Almasy]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Bauer]]></surname>
<given-names><![CDATA[L. O]]></given-names>
</name>
<name>
<surname><![CDATA[Kwon]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[The American Journal of Human Genetics]]></source>
<year>2004</year>
<volume>74</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>705-14</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gabriel]]></surname>
<given-names><![CDATA[S. B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8220;The Structure of Haplotype Blocks in the Human Genome&#8221;]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Schaffner]]></surname>
<given-names><![CDATA[S. F]]></given-names>
</name>
<name>
<surname><![CDATA[Nguyen]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Moore]]></surname>
<given-names><![CDATA[J. M]]></given-names>
</name>
<name>
<surname><![CDATA[Roy]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Blumenstiel]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Liu-Cordero]]></surname>
<given-names><![CDATA[S. N]]></given-names>
</name>
</person-group>
<source><![CDATA[Science]]></source>
<year>2002</year>
<volume>296</volume>
<numero>5576</numero>
<issue>5576</issue>
<page-range>2225-9</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fonseca]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8220;Deletions Identification in Female Carriers of Duchenne&#8217;s Muscular Distrophy&#8221;]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Mateus]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Restrepo]]></surname>
<given-names><![CDATA[C. M]]></given-names>
</name>
</person-group>
<source><![CDATA[Acta Medica Colombiana]]></source>
<year>2008</year>
<volume>33</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>63-7</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="">
<article-title xml:lang=""><![CDATA[&#8220;Introduction to design science methodology&#8221;]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wieringa]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Slides based on a book on Design Science methodology]]></source>
<year>2013</year>
</nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wieringa]]></surname>
<given-names><![CDATA[R. J]]></given-names>
</name>
</person-group>
<source><![CDATA[Design science methodology for information systems and software engineering]]></source>
<year>2014</year>
<publisher-name><![CDATA[Springer]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Delves]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Martin]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Burton]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Roitt]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<source><![CDATA[Inmunología: Fundamentos]]></source>
<year>2014</year>
<page-range>1-548</page-range><publisher-name><![CDATA[Médica Panamericana]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gibbs]]></surname>
<given-names><![CDATA[R. A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA["The international HapMap project."]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Belmont]]></surname>
<given-names><![CDATA[J. W]]></given-names>
</name>
<name>
<surname><![CDATA[Hardenbol]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Willis]]></surname>
<given-names><![CDATA[T. D]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Tam]]></surname>
<given-names><![CDATA[P. K. H]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature]]></source>
<year>2003</year>
<volume>426</volume>
<numero>6968</numero>
<issue>6968</issue>
<page-range>789-96</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cheung]]></surname>
<given-names><![CDATA[K. H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA["ALFRED: an allele frequency database for diverse populations and DNA polymorphisms"]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Osier]]></surname>
<given-names><![CDATA[M. V]]></given-names>
</name>
<name>
<surname><![CDATA[Kidd]]></surname>
<given-names><![CDATA[J. R]]></given-names>
</name>
<name>
<surname><![CDATA[Pakstis]]></surname>
<given-names><![CDATA[A. J]]></given-names>
</name>
<name>
<surname><![CDATA[Miller]]></surname>
<given-names><![CDATA[P. L]]></given-names>
</name>
<name>
<surname><![CDATA[Kidd]]></surname>
<given-names><![CDATA[K. K]]></given-names>
</name>
</person-group>
<source><![CDATA[Nucleic Acids Research]]></source>
<year>2000</year>
<volume>28</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>361-3</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Willuweit]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA["Y chromosome haplotype reference database (YHRD): update"]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Roewer]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<source><![CDATA[Forensic Science International: Genetics]]></source>
<year>2007</year>
<volume>1</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>83-7</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Higasa]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA["D-HaploDB: a database of definitive haplotypes determined by genotyping complete hydatidiform mole samples"]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Kukita]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Tahira]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<source><![CDATA[Nucleic Acids Research]]></source>
<year>2007</year>
<volume>35</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="confpro">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mayordomo]]></surname>
<given-names><![CDATA[A. M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Human genome conceptual modeling: An ontological framework for the design and implementation of genomic Information Systems]]></source>
<year>2012</year>
<conf-name><![CDATA[ Sixth International Conference on Research Challenges in Information Science (RCIS), IEEE]]></conf-name>
<conf-loc> </conf-loc>
<page-range>1-6</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ram]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA["Modeling the semantics of 3D protein structures&#8221;]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Wei]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<source><![CDATA[Conceptual Modeling-ER 2004]]></source>
<year>2004</year>
<page-range>696-708</page-range><publisher-name><![CDATA[Springer Berlin Heidelberg]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="confpro">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pastor]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Levin]]></surname>
<given-names><![CDATA[A. M]]></given-names>
</name>
<name>
<surname><![CDATA[Casamayor]]></surname>
<given-names><![CDATA[J. C]]></given-names>
</name>
<name>
<surname><![CDATA[Celma]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Eraso]]></surname>
<given-names><![CDATA[L. E]]></given-names>
</name>
<name>
<surname><![CDATA[Villanueva]]></surname>
<given-names><![CDATA[M. J]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez-Alonso]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Enforcing conceptual modeling to improve the understanding of human genome]]></source>
<year>2010</year>
<conf-name><![CDATA[ Fourth International Conference on Research Challenges in Information Science]]></conf-name>
<conf-loc> </conf-loc>
<page-range>85-92</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[A haplotype map of the human genome]]></article-title>
<source><![CDATA[Nature]]></source>
<year>2005</year>
<volume>437</volume>
<numero>7063</numero>
<issue>7063</issue>
<page-range>1299-320</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stephens]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8220;A New Statistical Method for Haplotype Reconstruction from Population Data&#8221;]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Smith]]></surname>
<given-names><![CDATA[N. J]]></given-names>
</name>
<name>
<surname><![CDATA[Donnelly]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[The American Journal of Human Genetics]]></source>
<year>2001</year>
<volume>68</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>978-89</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fallin]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8220;Accuracy of Haplotype Frequency Estimation for Biallelic Loci, via the Expectation-Maximization Algorithm for Unphased Diploid Genotype Data&#8221;]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Schork]]></surname>
<given-names><![CDATA[N. J]]></given-names>
</name>
</person-group>
<source><![CDATA[The American Journal of Human Genetics]]></source>
<year>2000</year>
<volume>67</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>947-59</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schaid]]></surname>
<given-names><![CDATA[D. J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8220;Score Tests for Association between Traits and Haplotypes when Linkage Phase Is Ambiguous&#8221;]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Rowland]]></surname>
<given-names><![CDATA[C. M]]></given-names>
</name>
<name>
<surname><![CDATA[Tines]]></surname>
<given-names><![CDATA[D. E]]></given-names>
</name>
<name>
<surname><![CDATA[Jacobson]]></surname>
<given-names><![CDATA[R. M]]></given-names>
</name>
<name>
<surname><![CDATA[Poland]]></surname>
<given-names><![CDATA[G. A]]></given-names>
</name>
</person-group>
<source><![CDATA[The American Journal of Human Genetics]]></source>
<year>2002</year>
<volume>70</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>425-34</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="">
<source><![CDATA[&#8220;Genética de Poblaciones&#8221;, Universidad de la República Uruguay]]></source>
<year>2003</year>
</nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barbadilla]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Genética de Poblaciones]]></source>
<year>2009</year>
</nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="">
<article-title xml:lang=""><![CDATA[Modelo de Hardy-Weinberg]]></article-title>
<source><![CDATA[Atlas of Genetics and Cytogenetics in Oncology and Haematology]]></source>
<year>2015</year>
</nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barrett]]></surname>
<given-names><![CDATA[J. C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA["Haploview: analysis and visualization of LD and haplotype maps"]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Fry]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Maller]]></surname>
<given-names><![CDATA[J. D. M. J]]></given-names>
</name>
<name>
<surname><![CDATA[Daly]]></surname>
<given-names><![CDATA[M. J]]></given-names>
</name>
</person-group>
<source><![CDATA[Bioinformatics]]></source>
<year>2005</year>
<volume>21</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>263-5</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reich]]></surname>
<given-names><![CDATA[D. E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA["Linkage disequilibrium in the human genome"]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Cargill]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Bolk]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Ireland]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Sabeti]]></surname>
<given-names><![CDATA[P. C.]]></given-names>
</name>
<name>
<surname><![CDATA[Richter]]></surname>
<given-names><![CDATA[D. J]]></given-names>
</name>
<name>
<surname><![CDATA[Lander]]></surname>
<given-names><![CDATA[E. S]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature]]></source>
<year>2001</year>
<volume>411</volume>
<numero>6834</numero>
<issue>6834</issue>
<page-range>199-204</page-range></nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Landrum]]></surname>
<given-names><![CDATA[M. J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA["ClinVar: public archive of relationships among sequence variation and human phenotype"]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[J. M]]></given-names>
</name>
<name>
<surname><![CDATA[Riley]]></surname>
<given-names><![CDATA[G. R]]></given-names>
</name>
<name>
<surname><![CDATA[Jang]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Rubinstein]]></surname>
<given-names><![CDATA[W. S]]></given-names>
</name>
<name>
<surname><![CDATA[Church]]></surname>
<given-names><![CDATA[D. M]]></given-names>
</name>
<name>
<surname><![CDATA[Maglott]]></surname>
<given-names><![CDATA[D. R]]></given-names>
</name>
</person-group>
<source><![CDATA[Nucleic Acids Research]]></source>
<year>2014</year>
<volume>42</volume>
</nlm-citation>
</ref>
<ref id="B35">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Johnston]]></surname>
<given-names><![CDATA[J. J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA["Databases of genomic variation and phenotypes: existing resources and future needs"]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Biesecker]]></surname>
<given-names><![CDATA[L. G]]></given-names>
</name>
</person-group>
<source><![CDATA[Human molecular genetics]]></source>
<year>2013</year>
</nlm-citation>
</ref>
<ref id="B36">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hubbard]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA["The Ensembl genome database project"]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Barker]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Birney]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Cameron]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Clark]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Durbin]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Nucleic Acids Research]]></source>
<year>2002</year>
<volume>30</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>38-41</page-range></nlm-citation>
</ref>
<ref id="B37">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Piñero]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA["DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes"]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Queralt-Rosinach]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Bravo]]></surname>
<given-names><![CDATA[Á]]></given-names>
</name>
<name>
<surname><![CDATA[Deu-Pons]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Bauer-Mehren]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Baron]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Furlong]]></surname>
<given-names><![CDATA[L. I]]></given-names>
</name>
</person-group>
<source><![CDATA[Database]]></source>
<year>2015</year>
<volume>2015</volume>
<page-range>bav028</page-range></nlm-citation>
</ref>
<ref id="B38">
<nlm-citation citation-type="confpro">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reyes Román]]></surname>
<given-names><![CDATA[J. F.]]></given-names>
</name>
<name>
<surname><![CDATA[Pastor]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<source><![CDATA[Use of GeIS for Early Diagnosis of Alcohol Sensitivity]]></source>
<year>2016</year>
<volume>3</volume>
<conf-name><![CDATA[ Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies]]></conf-name>
<conf-loc> </conf-loc>
<page-range>284-9</page-range></nlm-citation>
</ref>
<ref id="B39">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rosenbloom]]></surname>
<given-names><![CDATA[K. R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8220;The UCSC genome browser database: 2015 update&#8221;]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Armstrong]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Barber]]></surname>
<given-names><![CDATA[G. P]]></given-names>
</name>
<name>
<surname><![CDATA[Casper]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Clawson]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Diekhans]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Harte]]></surname>
<given-names><![CDATA[R. A]]></given-names>
</name>
</person-group>
<source><![CDATA[Nucleic Acids Research]]></source>
<year>2015</year>
<volume>42</volume>
<page-range>D764-70</page-range></nlm-citation>
</ref>
<ref id="B40">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kent]]></surname>
<given-names><![CDATA[W. J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8220;Exploring relationships and mining data with the UCSC Gene Sorter&#8221;]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Hsu]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Karolchik]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Kuhn]]></surname>
<given-names><![CDATA[R. M]]></given-names>
</name>
<name>
<surname><![CDATA[Clawson]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Trumbower]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Haussler]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Genome res]]></source>
<year>2005</year>
<volume>15</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>737-41</page-range></nlm-citation>
</ref>
<ref id="B41">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pastor]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8220;Model-driven development&#8221;]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[España]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Panach]]></surname>
<given-names><![CDATA[J. I]]></given-names>
</name>
<name>
<surname><![CDATA[Aquino]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<source><![CDATA[Informatik-Spektrum]]></source>
<year>2008</year>
<volume>31</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>394-407</page-range></nlm-citation>
</ref>
<ref id="B42">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Munoz]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8220;ETL process modeling conceptual for data warehouses: a systematic mapping study&#8221;]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Mazon]]></surname>
<given-names><![CDATA[J. N]]></given-names>
</name>
<name>
<surname><![CDATA[Trujillo]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Latin America Transactions]]></source>
<year>2011</year>
<volume>9</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>358-63</page-range></nlm-citation>
</ref>
<ref id="B43">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[&#8220;Wiki-Genome: A model-driven genome data management environment&#8221;]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martinez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[IEEE]]></source>
<year>2012</year>
<conf-name><![CDATA[ Sixth International Conference on Research Challenges in Information Science (RCIS)]]></conf-name>
<conf-loc> </conf-loc>
<page-range>1-6</page-range></nlm-citation>
</ref>
<ref id="B44">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pastor]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Conceptual modeling of human genome: Integration challenges]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Casamayor]]></surname>
<given-names><![CDATA[J. C]]></given-names>
</name>
<name>
<surname><![CDATA[Celma]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Mota]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Pastor]]></surname>
<given-names><![CDATA[M. Á]]></given-names>
</name>
<name>
<surname><![CDATA[Levin]]></surname>
<given-names><![CDATA[A. M]]></given-names>
</name>
</person-group>
<source><![CDATA[Conceptual Modelling and Its Theoretical Foundations]]></source>
<year>2012</year>
<page-range>231-50</page-range><publisher-name><![CDATA[Springer Berlin Heidelberg]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B45">
<nlm-citation citation-type="">
<source><![CDATA[NCBI. dbSNP ER Schema]]></source>
<year>2015</year>
</nlm-citation>
</ref>
<ref id="B46">
<nlm-citation citation-type="">
<source><![CDATA[Ensembl. Ensembl: Features_Analyses_Core Schema]]></source>
<year>2016</year>
</nlm-citation>
</ref>
<ref id="B47">
<nlm-citation citation-type="">
<source><![CDATA[UCSC. UCSC Genome Bioinformatics: Haplotypes representation]]></source>
<year>2015</year>
</nlm-citation>
</ref>
<ref id="B48">
<nlm-citation citation-type="confpro">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reyes Román]]></surname>
<given-names><![CDATA[J. F.]]></given-names>
</name>
<name>
<surname><![CDATA[Pastor]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Valverde]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Roldán]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Including haplotypes treatment in a Genomic Information Systems Management]]></source>
<year>2016</year>
<conf-name><![CDATA[ XIX Ibero-American Conference on Software Engineering (CIbSE 2016)]]></conf-name>
<conf-loc> </conf-loc>
<page-range>11-24</page-range></nlm-citation>
</ref>
<ref id="B49">
<nlm-citation citation-type="">
<source><![CDATA[ETL-Tools.Info, &#8220;Proceso ETL]]></source>
<year>2016</year>
</nlm-citation>
</ref>
<ref id="B50">
<nlm-citation citation-type="">
<source><![CDATA[HeidiSQL, &#8220;Basic help on using HeidiSQL]]></source>
<year>2016</year>
</nlm-citation>
</ref>
<ref id="B51">
<nlm-citation citation-type="book">
<source><![CDATA[PHP y MySQL: domine el desarrollo de un sitio web dinámico e interactivo]]></source>
<year>2014</year>
<publisher-name><![CDATA[ENI]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B52">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Date]]></surname>
<given-names><![CDATA[C. J]]></given-names>
</name>
</person-group>
<source><![CDATA[Introducción a los sistemas de bases de datos]]></source>
<year>2001</year>
<page-range>15-9</page-range><publisher-name><![CDATA[Pearson Educación]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B53">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Febles]]></surname>
<given-names><![CDATA[J. P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA["Aplicación de la minería de datos en la bioinformática"]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Acimed]]></source>
<year>2002</year>
<volume>10</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>69-76</page-range></nlm-citation>
</ref>
<ref id="B54">
<nlm-citation citation-type="">
<source><![CDATA[UCSC Genome Bioinformatics: Schema for Haplotypes - GRCh38 Haplotype to Reference Sequence Mapping Correspondence]]></source>
<year>2016</year>
</nlm-citation>
</ref>
<ref id="B55">
<nlm-citation citation-type="">
<source><![CDATA[The Sequence Ontology. Haplotype (Current_SVN)]]></source>
<year>2016</year>
</nlm-citation>
</ref>
<ref id="B56">
<nlm-citation citation-type="confpro">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Phan]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<source><![CDATA[dbSNP and dbVar: NCBI Databases of Simple and Structural Variations]]></source>
<year>2015</year>
<conf-name><![CDATA[ In Plant and Animal Genome XXIII Conference, Plant and Animal Genome]]></conf-name>
<conf-loc> </conf-loc>
</nlm-citation>
</ref>
<ref id="B57">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sherry]]></surname>
<given-names><![CDATA[S. T.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8220;dbSNP: the NCBI database of genetic variation&#8221;]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Ward]]></surname>
<given-names><![CDATA[M. H.]]></given-names>
</name>
<name>
<surname><![CDATA[Kholodov]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Baker]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Phan]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Smigielski]]></surname>
<given-names><![CDATA[E. M]]></given-names>
</name>
<name>
<surname><![CDATA[Sirotkin]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<source><![CDATA[Nucleic Acids Research]]></source>
<year>2001</year>
<volume>29</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>308-11</page-range></nlm-citation>
</ref>
<ref id="B58">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8220;Alcoholismo y sociedad, tendencias actuales&#8221;]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Lima]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Aldana]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Casanova]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Feliciano]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<source><![CDATA[Al de Medicina Militar]]></source>
<year>2014</year>
<volume>33</volume>
<numero>3</numero>
<issue>3</issue>
</nlm-citation>
</ref>
<ref id="B59">
<nlm-citation citation-type="">
<source><![CDATA[PubMed web, &#8220;Using PubMed]]></source>
<year>2016</year>
</nlm-citation>
</ref>
<ref id="B60">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Olivé]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Conceptual modeling of information systems]]></source>
<year>2007</year>
<publisher-name><![CDATA[Springer]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B61">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Saccone]]></surname>
<given-names><![CDATA[S. F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8220;BioQ: tracing experimental origins in public genomic databases using a novel data provenance model&#8221;]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Quan]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Jones]]></surname>
<given-names><![CDATA[P. L]]></given-names>
</name>
</person-group>
<source><![CDATA[Bioinformatics]]></source>
<year>2012</year>
<volume>28</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>1189-91</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
