<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1688-1249</journal-id>
<journal-title><![CDATA[Archivos de Pediatría del Uruguay]]></journal-title>
<abbrev-journal-title><![CDATA[Arch. Pediatr. Urug.]]></abbrev-journal-title>
<issn>1688-1249</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Uruguaya de Pediatría]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1688-12492024000301217</article-id>
<article-id pub-id-type="doi">10.31134/ap.95.2.6</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Evaluación del efecto sobre la estadía hospitalaria a propósito del cambio de tratamiento antibiótico intravenoso a vía oral en pacientes pediátricos apendicectomizados por apendicitis precoz en el Centro Hospitalario Pereira Rossell, 2020/2021]]></article-title>
<article-title xml:lang="en"><![CDATA[Evaluation of the effect on hospital stay in cases of moving from intravenous to oral antibiotic treatment in pediatric patients after appendicectomy for early appendicitis at the Pereira Rossell Pediatric Hospital 2020/2021]]></article-title>
<article-title xml:lang="pt"><![CDATA[Avaliação do efeito na permanência hospitalar em casos de mudança do tratamento antibiótico intravenoso para oral em pacientes pediátricos apendicectomizados por apendicite precoce no Centro Hospitalar Pereira Rossell, 2020/2021]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Britos]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Figueredo]]></surname>
<given-names><![CDATA[Emilene]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bonapelch]]></surname>
<given-names><![CDATA[Soledad]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cavalleri]]></surname>
<given-names><![CDATA[Fiorella]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,UDELAR Facultad de Medicina Dirección y Gestión Sanitaria]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,UDELAR Facultad de Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,UDELAR Facultad de Medicina Medicina Preventiva y Social]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,UDELAR Facultad de Medicina Medicina Preventiva y Social]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Uruguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<volume>95</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S1688-12492024000301217&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S1688-12492024000301217&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S1688-12492024000301217&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Objetivos: evaluar el efecto sobre el tiempo de estadía a propósito del cambio de modelo de tratamiento antibiótico en pacientes pediátricos cursando posoperatorio por apendicectomía precoz en el Centro Hospitalario Pereira Rossell (CHPR).  Metodología: se realizó un estudio cuasi experimental con grupo de control histórico. La población objetivo estuvo compuesta por niños, niñas y adolescentes cursando posoperatorio por apendicectomía precoz en el Servicio de Cirugía Pediátrica.  Resultados: se constató una diferencia estadísticamente significativa en el tiempo de internación poscirugía entre ambos grupos, diferencia que con una confianza de 95% podría ser por lo menos de 14 horas y como máximo de 33 horas. La magnitud del efecto en el tiempo de internación del grupo que recibió antibiótico vía oral luego de la apendicectomía, respecto de los que recibieron antibiótico por vía intravenosa, fue grande.  Conclusiones:  la nueva modalidad de tratamiento implementada para el posoperatorio de apendicitis aguda precoz (edematosas y flemonosas) por vía oral se asoció con una menor estancia hospitalaria. Esto conlleva, según los antecedentes existentes, a un menor riesgo de infecciones intrahospitalarias, una menor disrupción del entorno familiar del niño y a un uso más eficiente del recurso cama.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Summary:  Objetives:  assess the effect of hospital stay length when changing the antibiotic treatment model in pediatric patients undergoing postoperative early appendectomy at the Pereira Rossell Hospital.  Methodology:  a quasi-experimental study was carried out, with a historical control group. The target population was integrated by boys, girls and adolescents, undergoing postoperative early appendectomy in the Pediatric Surgical Ward.  Results:  a statistically significant difference was found in the post-surgery hospitalization time in both groups, a difference that with 95% confidence could be at least 14 hours and at the most 33. The significance of the effect on the hospitalization time of the group that received oral antibiotics after appendectomy, compared to those who received intravenous antibiotics was large.  Conclusions:  the new oral treatment modality implemented for the postoperative period of early acute appendicitis (edematous and phlegmonous) was linked to a shorter hospital stay. This leads, according to existing precedents, to a lower risk of in-hospital infections, less disruption of the child&#8217;s family environment and a more efficient use of bed resources.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Objetivos: avaliar o efeito no tempo de internação da mudança no modelo de tratamento antibiótico em pacientes pediátricos submetidos à apendicectomia precoce pós-operatória no Hospital Pereira Rossell.  Metodologia:  foi realizado um estudo quase experimental, com o grupo de controle histórico. A população-alvo foi composta por meninos, meninas e adolescentes, submetidos ao pós-operatório de apendicectomia precoce no Serviço de Cirurgia Pediátrica.  Resultados: foi encontrada diferença estatisticamente significativa no tempo de internação pós-cirúrgica em ambos os grupos, diferença que com 95% de confiança poderia ser de no mínimo 14 horas e no máximo 33. A magnitude do efeito no tempo de internação do grupo que recebeu via oral antibióticos após apendicectomia, em comparação com aqueles que receberam antibióticos intravenosos foi grande.  Conclusões: a nova modalidade de tratamento oral implementada no pós-operatório de apendicite aguda precoce (edematosa e flegmonosa) esteve associada a menor tempo de internação. Isso leva, de acordo com os precedentes existentes, a um menor risco de infecções hospitalares, a uma menor perturbação do ambiente familiar da criança e a uma utilização mais eficiente do recurso cama.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Apendicitis]]></kwd>
<kwd lng="es"><![CDATA[Cuidados Posoperatorios]]></kwd>
<kwd lng="es"><![CDATA[Tiempo de Internación]]></kwd>
<kwd lng="es"><![CDATA[Ampicilina]]></kwd>
<kwd lng="es"><![CDATA[Amoxicilina]]></kwd>
<kwd lng="en"><![CDATA[Appendicitis]]></kwd>
<kwd lng="en"><![CDATA[Postoperative Care]]></kwd>
<kwd lng="en"><![CDATA[Hospitalization Time]]></kwd>
<kwd lng="en"><![CDATA[Ampicillin]]></kwd>
<kwd lng="en"><![CDATA[Amoxicillin]]></kwd>
<kwd lng="pt"><![CDATA[Apendicite]]></kwd>
<kwd lng="pt"><![CDATA[Pós-Operatório]]></kwd>
<kwd lng="pt"><![CDATA[Tempo de Internação]]></kwd>
<kwd lng="pt"><![CDATA[Ampicilina]]></kwd>
<kwd lng="pt"><![CDATA[Amoxicilina]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Akkoyun]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Outpatient laparoscopic appendectomy in children a single center experience with 92 cases]]></article-title>
<source><![CDATA[Surg Laparosc Endosc Percutan Tech]]></source>
<year>2013</year>
<volume>23</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>49-50</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kleinman]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Fraga]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bouzas]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Berazategui]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Laparoscopía y apendicectomía laparoscópica en niños: experiencia nacional]]></article-title>
<source><![CDATA[Arch Pediatr Urug]]></source>
<year>2010</year>
<volume>81</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>5-15</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hansen]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Kleif]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Jakobsen]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Paerregaard]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Changes in incidence and management of acute appendicitis in children-a population-based study in the period 2000-2015]]></article-title>
<source><![CDATA[Eur J Pediatr Surg]]></source>
<year>2021</year>
<volume>31</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>347-52</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[García Camiño]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Campillo i López]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Delgado Díez]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Ballesteros Moya]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Calle Gómez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Martín Sánchez]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Apendicitis en menores de cuatro años identificación de signos, síntomas y parámetros analíticos y radiológicos hacia un diagnóstico precoz]]></article-title>
<source><![CDATA[Rev Pediatr Aten Primaria]]></source>
<year>2014</year>
<volume>16</volume>
<numero>63</numero>
<issue>63</issue>
<page-range>213-8</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Salö]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ohlsson]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Arnbjörnsson]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Stenström]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Appendicitis in children from a gender perspective]]></article-title>
<source><![CDATA[Pediatr Surg Int]]></source>
<year>2015</year>
<volume>31</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>845-53</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cheng]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Cheng]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Burjonrappa]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Facilitating factors in same-day discharge after pediatric laparoscopic appendectomy]]></article-title>
<source><![CDATA[J Surg Res]]></source>
<year>2018</year>
<volume>229</volume>
<page-range>145-9</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Esparaz]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Jeziorczak]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Mowrer]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Chakraborty]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Nierstedt]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Zumpf]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Adopting single-incision laparoscopic appendectomy in children: is it safe during the learning curve?]]></article-title>
<source><![CDATA[J Laparoendosc Adv Surg Tech A]]></source>
<year>2019</year>
<volume>29</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>1306-10</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="">
<collab>Universidad de la República</collab>
<collab>Facultad de Medicina</collab>
<collab>Cátedra de Cirugía Pediátrica</collab>
<source><![CDATA[Pautas de manejo clínico en cirugía pediátrica: apendicitis aguda]]></source>
<year>2007</year>
<publisher-loc><![CDATA[Solís ]]></publisher-loc>
</nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arnold]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Wormer]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Kao]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Klima]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Colavita]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Cosper]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Home intravenous versus oral antibiotics following appendectomy for perforated appendicitis in children a randomized controlled trial]]></article-title>
<source><![CDATA[Pediatr Surg Int]]></source>
<year>2018</year>
<volume>34</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1257-68</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[van den Boom]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[de Wijkerslooth]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Wijnhoven]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Systematic review and meta-analysis of postoperative antibiotics for patients with a complex appendicitis]]></article-title>
<source><![CDATA[Dig Surg]]></source>
<year>2020</year>
<volume>37</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>101-10</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[de Wijkerslooth]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Boerma]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[van Rossem]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[van Rosmalen]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Baeten]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Beverdam]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[2 days versus 5 days of postoperative antibiotics for complex appendicitis a pragmatic, open-label, multicentre, non-inferiority randomised trial]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2023</year>
<volume>401</volume>
<numero>10374</numero>
<issue>10374</issue>
<page-range>366-76</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Song]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Suh]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Bacterial culture and antibiotic susceptibility in patients with acute appendicitis]]></article-title>
<source><![CDATA[Int J Colorectal Dis]]></source>
<year>2018</year>
<volume>33</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>441-7</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Minneci]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Deans]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evolving issues in the use of antibiotics for the treatment of uncomplicated appendicitis]]></article-title>
<source><![CDATA[JAMA]]></source>
<year>2021</year>
<volume>325</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>351-2</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bechis]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Michel]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Merrot]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Nicoleta]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Lando]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Leone]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparaison de deux protocoles d antibioprophylaxie associée à l appendicectomie de l enfant]]></article-title>
<source><![CDATA[Arch Pediatr]]></source>
<year>2014</year>
<volume>21</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>1167-72</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Minneci]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Mahida]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Lodwick]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Sulkowski]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Nacion]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Cooper]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effectiveness of patient choice in nonoperative vs surgical management of pediatric uncomplicated acute appendicitis]]></article-title>
<source><![CDATA[JAMA Surg]]></source>
<year>2016</year>
<volume>151</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>408-15</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Montilla]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Kromrey]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Robustez de las pruebas T en comparación de medias, ante violación de supuestos de normalidad y homocedasticidad]]></article-title>
<source><![CDATA[Cien Ing]]></source>
<year>2010</year>
<volume>31</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>101-8</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Domínguez-Lara]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Magnitud del efecto, una guía rápida]]></article-title>
<source><![CDATA[Educ Med]]></source>
<year>2018</year>
<volume>19</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>251-4</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="book">
<collab>R Foundation for Statistical Computing</collab>
<source><![CDATA[R Core Team (2019) R: a language and environment for statistical computing]]></source>
<year>2019</year>
<publisher-loc><![CDATA[Vienna ]]></publisher-loc>
<publisher-name><![CDATA[R Foundation for Statistical Computing]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Scott]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Shekherdimian]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Rouch]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Sacks]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Dawes]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Lui]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Same-day discharge in laparoscopic acute non-perforated appendectomy]]></article-title>
<source><![CDATA[J Am Coll Surg]]></source>
<year>2017</year>
<volume>224</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>43-8</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cunha]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intravenous-to-oral antibiotic switch therapy a cost-effective approach]]></article-title>
<source><![CDATA[Postgrad Med]]></source>
<year>1997</year>
<volume>101</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>111-2</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kilgore]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ghosh]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Beavers]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Wong]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Hymel]]></surname>
<given-names><![CDATA[PJr]]></given-names>
</name>
<name>
<surname><![CDATA[Brossette]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The costs of nosocomial infections]]></article-title>
<source><![CDATA[Med Care]]></source>
<year>2008</year>
<volume>46</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>101-4</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stickland]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Clayton]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Sankey]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Hill]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A qualitative study of sleep quality in children and their resident parents when in hospital]]></article-title>
<source><![CDATA[Arch Dis Child]]></source>
<year>2016</year>
<volume>101</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>546-51</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Doupnik]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Hill]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Palakshappa]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Worsley]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Bae]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Shaik]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Parent coping support interventions during acute pediatric hospitalizations a meta-analysis]]></article-title>
<source><![CDATA[Pediatrics]]></source>
<year>2017</year>
<volume>140</volume>
<numero>3</numero>
<issue>3</issue>
</nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="book">
<collab>Organización Panamericana de la Salud</collab>
<source><![CDATA[Directrices sobre componentes básicos para los programas de prevención y control de infecciones a nivel nacional y de establecimientos de atención de salud para pacientes agudos]]></source>
<year>2017</year>
<publisher-loc><![CDATA[Washington, DC ]]></publisher-loc>
<publisher-name><![CDATA[OPS]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barrios]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Le Pera]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Icardi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Chiparelli]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Algorta]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Stoll]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Infecciones intrahospitalarias por adenovirus en niños asistidos en el Centro Hospitalario Pereira Rossell, 2001-2006]]></article-title>
<source><![CDATA[Rev Méd Urug]]></source>
<year>2009</year>
<volume>25</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>102-9</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Caamaño]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Sastre]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Figueiras]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estudios de utilización de medicamentos]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Fernández Crehuet Navajas]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Gestal Otero]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Delgado Rodríguez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Bolúmar Montrull]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Herruzo Cabrera]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Serra Majem]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<source><![CDATA[Piédrola Gil Medicina preventiva y salud pública]]></source>
<year>2016</year>
<edition>12</edition>
<page-range>1104-13</page-range><publisher-loc><![CDATA[Barcelona ]]></publisher-loc>
<publisher-name><![CDATA[Elsevier-Masson]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kashyap]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Reisen]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Hornick]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Nace]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Laje]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Same-day discharge after laparoscopic appendectomy for non-perforated appendicitis is safe and cost effective]]></article-title>
<source><![CDATA[Pediatr Surg Int]]></source>
<year>2021</year>
<volume>37</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>859-63</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Orthopoulos]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Santone]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Izzo]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Tirabassi]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez-Caraballo]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Corriveau]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Increasing incidence of complicated appendicitis during COVID-19 pandemic]]></article-title>
<source><![CDATA[Am J Surg]]></source>
<year>2021</year>
<volume>221</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1056-60</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Baral]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Chhetri]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Thapa]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparison of acute appendicitis before and within lockdown period in COVID-19 era A retrospective study from rural Nepal]]></article-title>
<source><![CDATA[PLoS One]]></source>
<year>2021</year>
<volume>16</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Finkelstein]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Picado]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Muddasani]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Wodnicki]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Mesko]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Unger]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A retrospective analysis of the trends in acute appendicitis during the COVID-19 pandemic]]></article-title>
<source><![CDATA[J Laparoendosc Adv Surg Tech A]]></source>
<year>2021</year>
<volume>31</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>243-6</page-range></nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lee-Archer]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Blackall]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Campbell]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Boyd]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Patel]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[McBride]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Increased incidence of complicated appendicitis during the COVID-19 pandemic]]></article-title>
<source><![CDATA[J Paediatr Child Health]]></source>
<year>2020</year>
<volume>56</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>1313-4</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
