1688-1249 1688-1249 S1688-12492021000301305 10.31134/ap.92.2.5 Uruguay Uruguay Uruguay Uruguay Uruguay 00 12 2021 00 12 2021 92 2

1 2011 12 1031-66 2 2012 3 191-202 3 2008 69 6 6 586-7 4 2015 41 ^s2 ^s2 2 A74 5 2001 72 ^s1 ^s1 1 S5-13 6 2014 134 4 4 e976-82 7 Agencia Española de Medicamentos y Productos Sanitarios 2019 8 Food and Drug Administration 2009 9 2007 8 18 18 3195-203 10 2017 21 80-5 11 2019 9 1 1 71 12 2019 55 1 1 52 13 2009 71 1 1 82-3 14 2017 88 3 3 142-8