<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1688-0420</journal-id>
<journal-title><![CDATA[Revista Uruguaya de Cardiología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev.Urug.Cardiol.]]></abbrev-journal-title>
<issn>1688-0420</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Uruguaya de Cardiología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1688-04202020000300234</article-id>
<article-id pub-id-type="doi">10.29277/cardio.35.3.16</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Prevención y manejo del sangrado en cirugía cardíaca]]></article-title>
<article-title xml:lang="en"><![CDATA[Management of bleeding in the cardiac surgery setting]]></article-title>
<article-title xml:lang="pt"><![CDATA[Prevenção e gerenciamento de sangramento na cirurgia cardíaca]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Delgado]]></surname>
<given-names><![CDATA[Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Machado]]></surname>
<given-names><![CDATA[Washington]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Machado]]></surname>
<given-names><![CDATA[Gonzalo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Cirugía Cardíaca  ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital de Clínicas Centro Cardiovascular Universitario ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<volume>35</volume>
<numero>3</numero>
<fpage>234</fpage>
<lpage>274</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S1688-04202020000300234&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S1688-04202020000300234&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S1688-04202020000300234&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: Todo procedimiento quirúrgico supone grados variables de agresión. La cirugía cardíaca (CC) con el uso muchas veces necesario de la circulación extracorpórea (CEC), impacta particularmente sobre múltiples sistemas orgánicos. En el presente trabajo, se analizará su repercusión sobre la hemostasia. El sangrado es una de las complicaciones más frecuentes y con mayor morbimortalidad durante el posoperatorio de CC. Aunque de causa multifactorial, adquieren especial relevancia la técnica quirúrgica, el tiempo de CEC y las enfermedades preexistentes. La aparición de nuevos fármacos procoagulantes y sistemas de monitorización de la hemostasia, junto al uso de protocolos de manejo con buena evidencia pero baja adherencia, no han logrado hasta el momento disminuir el uso de hemocomponentes. En esta revisión analizamos las recomendaciones actuales para el manejo del sangrado en CC, su prevención a través de la optimización preoperatoria del paciente, la estratificación del riesgo, el sostén de la hemostasia intraoperatoria y el tratamiento de las complicaciones hemorrágicas posoperatorias.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Summary: Any surgical procedure is detrimental to the body. Cardiac surgery with the necessary use of cardiopulmonary bypass particularly impacts on multiple systems. In this review, emphasis will be placed on its impact on hemostasis. Bleeding is one of the most frequent complications and with the highest morbidity and mortality in these patients. Although it is caused by a number of factors, the surgical technique, the cardiopulmonary bypass time and the pre-existing diseases acquire special relevance. The appearance of new procoagulant drugs and systems for monitoring hemostasis, the use of management protocols, with good evidence but low adherence, have so far not been able to reduce the use of blood components. In this review we analyse the current recommendations for the management of bleeding in cardiac surgery, its prevention through the preoperative optimization of the patient, stratify their risk, maintain intraoperative hemostasis and treat postoperative bleeding complications in those patients who suffer them.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo: Todo procedimento cirúrgico envolve diferentes graus de agressão. A cirurgia cardíaca com o uso necessário da circulação extracorpórea impacta particularmente vários sistemas. Neste trabalho, será dada ênfase ao seu impacto na hemostase. O sangramento é uma das complicações mais comuns e mórbidas nesses pacientes. Embora mutifatorial na causa, a técnica cirúrgica, o tempo da circulação extracorpórea e as doenças pré-existentes tornam-se particularmente relevantes. O surgimento de novas drogas procoagulantes, novos sistemas de monitoramento de hemostase e o uso de protocolos de gestão com boas evidências mas baixa adesão até agora não conseguiram diminuir até agora o uso de hemocomponentes. Nesta revisão nós analisamos as recomendações atuais para o manejo do sangramento na cirurgia cardíaca, sua prevenção através da otimização pré-operatória do paciente, a estratificação do risco, o apoio da hemostase intraoperatória e o tratamento de complicações hemorrágicas pós-operatórias daqueles pacientes que os apresentam.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Sangrado posoperatorio]]></kwd>
<kwd lng="es"><![CDATA[Profilaxis]]></kwd>
<kwd lng="es"><![CDATA[Manejo]]></kwd>
<kwd lng="en"><![CDATA[Postoperative bleeding]]></kwd>
<kwd lng="en"><![CDATA[Prophylaxis]]></kwd>
<kwd lng="en"><![CDATA[Management]]></kwd>
<kwd lng="pt"><![CDATA[Sangramento pós-operatório]]></kwd>
<kwd lng="pt"><![CDATA[Profilaxia]]></kwd>
<kwd lng="pt"><![CDATA[Gestão]]></kwd>
</kwd-group>
</article-meta>
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