<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1688-0420</journal-id>
<journal-title><![CDATA[Revista Uruguaya de Cardiología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev.Urug.Cardiol.]]></abbrev-journal-title>
<issn>1688-0420</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Uruguaya de Cardiología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1688-04202017000300321</article-id>
<article-id pub-id-type="doi">10.29277/ruc/32.3.13</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Insuficiencia cardíaca en el mundo real. Un punto de vista italiano]]></article-title>
<article-title xml:lang="en"><![CDATA[Real world evidence of heart failure: an Italian point of view]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Maggioni]]></surname>
<given-names><![CDATA[Aldo P.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Orso]]></surname>
<given-names><![CDATA[Francesco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Calabria]]></surname>
<given-names><![CDATA[Silvia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rossi]]></surname>
<given-names><![CDATA[Elisa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martini]]></surname>
<given-names><![CDATA[Nello]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,ANMCO Research Center  ]]></institution>
<addr-line><![CDATA[Florencia ]]></addr-line>
<country>Italia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universitaria Careggi Departamento de Geriatría Sección de Medicina Geriátrica y Cardiología]]></institution>
<addr-line><![CDATA[Florencia ]]></addr-line>
<country>Italia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Collaborative Outcome Research  ]]></institution>
<addr-line><![CDATA[Boloña ]]></addr-line>
<country>Italia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,CINECA Interuniversity Consortium Casalecchio di Reno ]]></institution>
<addr-line><![CDATA[Boloña ]]></addr-line>
<country>Italia</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Drugs &amp; Health  ]]></institution>
<addr-line><![CDATA[Roma ]]></addr-line>
<country>Italia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<volume>32</volume>
<numero>3</numero>
<fpage>321</fpage>
<lpage>329</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S1688-04202017000300321&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S1688-04202017000300321&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S1688-04202017000300321&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivos:  las características de la población de pacientes con insuficiencia cardíaca (IC) en los estudios clínicos aleatorizados (ECA) son, generalmente, muy distintas a las de la práctica real debido a criterios específicos de elegibilidad. Estos pacientes no representan totalmente &#8220;el mundo real&#8221; de esta condición clínica. El análisis de una base de datos administrativa puede ser útil para describir mejor las características de los pacientes con IC en el mundo real.  Métodos:  los datos provienen del observatorio italiano ARNO, que incluye una población de aproximadamente 2.500.000 de personas registradas en el Servicio Sanitario Nacional Italiano (SSNI). Fueron seleccionados los egresos por IC (1 de enero de 2008 al 31 diciembre de 2012). Describimos las características clínicas, los tratamientos, la tasa y causas de rehospitalizaciones y los costos directos para el SSNI ocasionados durante un año de seguimiento.  Resultados:  de los 2.456.739 individuos incluidos en la base de datos, 54.059 (2,2%) fueron hospitalizados por IC, 41.413 fueron dados de alta con vida con un tratamiento prescripto para su IC. La edad media fue de 78±11 años, las mujeres fueron el 51,4%. Solo 26,6% fue manejado en un ámbito cardiológico. Las comorbilidades más frecuentes fueron diabetes (30,7%), enfermedad pulmonar obstructiva crónica (EPOC) (30,5%) y depresión (21%). Inhibidores de la enzima convertidora de angiotensina y antagonistas de receptores de angiotensina (IECA/ARAII), betabloqueantes (BB) y antagonistas de receptor de mineralocorticoides (ARM) fueron prescriptos en 65,8%, 49,7% y 42,1% respectivamente. Al menos una rehospitalización ocurrió en 56,6% de los pacientes en un año de seguimiento, el 49% de ellas fueron por causas no cardiovasculares. El costo directo por paciente fue de 11.867 euros por año, debido fundamentalmente a la hospitalización.  Conclusiones:  la evidencia del mundo real provee una descripción de las características de los pacientes y los patrones de tratamiento que son muy diferentes de aquellos reportados en los ECA. Los costos del SNISS son ocasionados principalmente por las hospitalizaciones, las cuales frecuentemente se deben a causas no cardiovasculares.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Summary  Aims: the population of patients with heart failure (HF) randomized in clinical trials is generally far from real practice because selected according to specific eligibility criteria. These patients do not fully represent the &#8220;real world&#8221; of this clinical condition. Analysis of an administrative database can be useful to better describe the characteristics of real world patients with HF.  Methods: data came from the Italian ARNO Observatory including a population of nearly 2,500,000 inhabitants of the Italian National Health Service (INHS). Patients were selected when discharged for HF (January 1, 2008 - December 31, 2012). We described the clinical characteristics the pharmacological treatments, rate and type of re-hospitalizations and direct costs for the INHS occurring during 1 year follow-up (FU).  Results: of the 2,456,739 subjects included in the database, 54,059 (2.2%) were hospitalized for HF: 41,413 were discharged alive and prescribed on HF treatments. Mean age was 78±11 years, females accounted for 51.4%. Just 26.6% were managed in a cardiology setting. The more frequent co-morbidities were diabetes (30.7%), COPD (30.5%) and depression (21%). ACE-inhibitors/Angiotensin Receptor Blockers, Betablockers and Aldosterone antagonists were prescribed in 65.8, 49.7 and 42.1% of patients. At least one re-hospitalization occurred during the 1-year follow-up in 56.6% of patients, 49% of them were due to non-cardiovascular causes. INHS&#8217;s direct cost per patient per year was 11,867&#8364; mainly driven by hospitalizations.  Conclusions: real world evidence provides a description of patients&#8217; characteristics and treatment patterns that are very different from those reported by randomized clinical trials. Costs for the INHS are mainly driven by hospitalizations which are often due to non-cardiovascular reasons.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Insuficiencia cardíaca]]></kwd>
<kwd lng="es"><![CDATA[Tratamiento farmacológico]]></kwd>
<kwd lng="en"><![CDATA[Heart failure]]></kwd>
<kwd lng="en"><![CDATA[drug therapy]]></kwd>
</kwd-group>
</article-meta>
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