<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1688-0390</journal-id>
<journal-title><![CDATA[Revista Médica del Uruguay]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Méd. Urug.]]></abbrev-journal-title>
<issn>1688-0390</issn>
<publisher>
<publisher-name><![CDATA[Sindicato Médico del Uruguay]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1688-03902021000401205</article-id>
<article-id pub-id-type="doi">10.29193/rmu.37.4.5</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Coagulopatía asociada al trauma en la Unidad de Cuidados Intensivos]]></article-title>
<article-title xml:lang="en"><![CDATA[Trauma associated coagulopathy in the Intensive Care Unit]]></article-title>
<article-title xml:lang="pt"><![CDATA[Coagulopatia associada a trauma em Unidade de Terapia Intensiva]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Grille]]></surname>
<given-names><![CDATA[Pedro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Herrerin]]></surname>
<given-names><![CDATA[Andrea]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Verga]]></surname>
<given-names><![CDATA[Federico]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,ASSE Hospital Maciel Unidad de Cuidados Intensivos]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,ASSE Hospital Maciel Unidad de Cuidados Intensivos]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>37</volume>
<numero>4</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S1688-03902021000401205&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S1688-03902021000401205&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S1688-03902021000401205&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción: la enfermedad traumática es un problema de salud mundial. La coagulopatía asociada al trauma (CAT) constituye una complicación grave, multifactorial y de diagnóstico controversial.  Objetivos:  valorar la incidencia de CAT, los factores asociados a su desarrollo y su asociación con el pronóstico, en una serie de pacientes traumatizados ingresados a la Unidad de Cuidados Intensivos de nuestro hospital.  Pacientes y métodos:  estudio prospectivo de todos los pacientes ingresados con diagnóstico de trauma grave a la UCI. Se definió CAT en base a los parámetros clásicos de laboratorio, por la presencia de al menos uno de: INR mayor a 1,3, plaquetopenia menor a 100.000/mm3, y/o aPTT mayor a 38 segundos. Las variables continuas se expresaron como la media ± desvío estándar. Se realizó análisis de chi cuadrado, test exacto de Fisher y regresión logística binaria para estudiar la asociación entre las variables. Se consideró significativo un valor p &lt; 0,05.  Resultados:  se analizaron 103 pacientes, con media de edad de 33 años y predominio de sexo masculino. Se encontró CAT en 42 pacientes (40,8%), presentándose al ingreso hospitalario en la mayoría de los casos. Los factores de riesgo asociados a CAT fueron: gravedad al ingreso, shock, hipoperfusión, acidosis, transfusión masiva, sangrado significativo (estudio univariado), así como trauma penetrante y disfunción multiorgánica (estudio multivariado). No se encontró asociación significativa entre CAT y mortalidad.  Conclusiones:  presentamos el primer reporte de este tema en nuestro medio. En nuestra población la CAT es frecuente y se presenta ya al ingreso hospitalario. Se relaciona con la gravedad y el tipo de trauma. Su diagnóstico precoz es clave en el manejo de los pacientes con trauma grave.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  trauma is a global health problem. Trauma-associated coagulopathy constitutes a severe and multifactorial complication whose diagnosis is controversial.  Objectives:  to assess the incidence of trauma-associated coagulopathy, the factors associated to the development of this condition and their impact on prognosis in a series of trauma patients admitted into the intensive care unit of our hospital.  Method:  prospective study of all patients admitted to the ICU with a diagnosis of acute trauma. Trauma-associated coagulopathy was defined according to classical laboratory parameters, when it complies with one of the following: International normalized ratio (INR) greater than 1.3, thrombocytopenia smaller than 100000/mm3, and/or aPTT greater than 38 seconds. Continuous variables were expressed as the average ± standard deviation. The chi square analysis, Fisher exact test and binary logistic regression were performed, p &lt; 0,05 being considered significant.  Results:  103 patients were analysed, average age was 33 years old and they were mostly male. Trauma-associated coagulopathy was found in 42 patients (40.8 %), and it was seen in most patients at the time they were hospitalized. Risk factors of trauma-associated coagulopathy were the following: severity upon hospitalization, shock, hypoperfusion, acidosis, massive transfusion, significant bleeding (univariate analysis); penetrating trauma and multi-organ dysfunction (multivariate analysis). No significant association between trauma- associated coagulopathy and mortality was found.  Conclusions:  the study presents the first report on this topic in our country. Trauma associated coagulopathy is rather common in our population and it is seen upon hospitalization. This condition is related to severity and the kind of trauma. Early diagnosis is essential in the handling of patients with severe trauma.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução:  as doenças traumáticas são um problema de saúde global. A coagulopatia associada a trauma (TAC) é uma complicação diagnóstica séria, multifatorial e controversa.  Objetivos:  avaliar a incidência de TAC, os fatores associados ao seu desenvolvimento e sua associação com o prognóstico, em uma série de pacientes com trauma internados na Unidade de Terapia Intensiva do Hospital Maciel em Montevidéu, Uruguai.  Pacientes e métodos:  estudo prospectivo de todos os pacientes admitidos na UTI com diagnóstico de trauma grave. A TAC foi definida com base nos parâmetros laboratoriais clássicos, pela presença de pelo menos um dos seguintes: coeficiente internacional normalizado - INR maior que 1,3, trombocitopenia menor que 100.000 / mm3 e / ou PTTa maior que 38 segundos. As variáveis contínuas foram expressas como média ± desvio padrão. A análise do qui-quadrado, o teste exato de Fisher e a regressão logística binária foram realizados para estudar a associação entre as variáveis. Um valor de p &lt;0,05 foi considerado significativo.  Resultados: foram analisados 103 pacientes, com média de idade de 33 anos e predomínio do sexo masculino. A TAC foi encontrada em 42 pacientes (40,8%), apresentando-se na admissão hospitalar na maioria dos casos. Os fatores de risco associados à TAC foram: gravidade na admissão, choque, hipoperfusão, acidose, transfusão massiva, sangramento significativo (estudo univariado); bem como trauma penetrante e disfunção de múltiplos órgãos (estudo multivariado). Nenhuma associação significativa foi encontrada entre CAT e mortalidade.  Conclusões: apresentamos o primeiro relatório sobre o tema em nosso meio. Em nossa população, a TAC é frequente e já está presente na admissão hospitalar. Está relacionado à gravidade e ao tipo de trauma. Seu diagnóstico precoce é fundamental no manejo de pacientes com traumas graves.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Coagulopatía]]></kwd>
<kwd lng="es"><![CDATA[Trauma]]></kwd>
<kwd lng="es"><![CDATA[Choque hemorrágico]]></kwd>
<kwd lng="es"><![CDATA[Transfusión masiva]]></kwd>
<kwd lng="en"><![CDATA[Coagulopathy]]></kwd>
<kwd lng="en"><![CDATA[Trauma]]></kwd>
<kwd lng="en"><![CDATA[Hemorrhagic shock]]></kwd>
<kwd lng="en"><![CDATA[Massive transfusion]]></kwd>
<kwd lng="pt"><![CDATA[Coagulopatia]]></kwd>
<kwd lng="pt"><![CDATA[Trauma]]></kwd>
<kwd lng="pt"><![CDATA[Choque hemorrágico]]></kwd>
<kwd lng="pt"><![CDATA[Transfusão masiva]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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