<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1688-0390</journal-id>
<journal-title><![CDATA[Revista Médica del Uruguay]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Méd. Urug.]]></abbrev-journal-title>
<issn>1688-0390</issn>
<publisher>
<publisher-name><![CDATA[Sindicato Médico del Uruguay]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1688-03902018000300062</article-id>
<article-id pub-id-type="doi">10.29193/rmu.34.3.2</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Un programa de ejercicio de 20 semanas mejora marcadores de estatus cognitivo, inflamatorios y metabólicos en pacientes diabéticos tipo 2]]></article-title>
<article-title xml:lang="en"><![CDATA[A 20 week exercise program improves markers of cognitive, inflammatory and metabolic status in patients with type 2 diabetes]]></article-title>
<article-title xml:lang="pt"><![CDATA[Um programa de exercícios de 20 semanas melhora os marcadores de status cognitivo, inflamatórios e metabólicos em pacientes diabéticos tipo 2]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pisabarro]]></surname>
<given-names><![CDATA[Raúl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gutiérrez]]></surname>
<given-names><![CDATA[Mauricio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Orellano]]></surname>
<given-names><![CDATA[Pablo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Charamelo]]></surname>
<given-names><![CDATA[Ana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Llado]]></surname>
<given-names><![CDATA[Natalia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Kamaid]]></surname>
<given-names><![CDATA[Ana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mattiozzi]]></surname>
<given-names><![CDATA[Andrea]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mazza]]></surname>
<given-names><![CDATA[Milton]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de la República  Facultad de Medicina]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de la República Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de la República Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de la República Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad de la República Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Universidad de la República Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af7">
<institution><![CDATA[,Universidad de la República Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<aff id="Af8">
<institution><![CDATA[,Universidad de la República Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Montevideo ]]></addr-line>
<country>Uruguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2018</year>
</pub-date>
<volume>34</volume>
<numero>3</numero>
<fpage>62</fpage>
<lpage>85</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_arttext&amp;pid=S1688-03902018000300062&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_abstract&amp;pid=S1688-03902018000300062&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.edu.uy/scielo.php?script=sci_pdf&amp;pid=S1688-03902018000300062&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La diabetes mellitus tipo 2 es debida a la insulino-resistencia en el 90% de los casos y es determinante de riesgo para demencia vascular y enfermedad de Alzheimer. La inflamación, sistémica y crónica, de bajo grado de intensidad determina pérdida de sensibilidad a la insulina en el cerebro y deterioro cognitivo. El objetivo de este trabajo fue evaluar el impacto de un programa de ejercicio de 20 semanas sobre el estatus cognitivo (incluyendo calidad de vida) e inflamatorio en una muestra de diabéticos mellitus tipo 2 cuyo diagnóstico es menor o igual a diez años, asistidos por nuestro Sistema Nacional Integrado de Salud (SNIS).  Método:  el estudio fue clínico, abierto, randomizado y controlado con pacientes en nivel primario de atención. De los 168 pacientes diabéticos tipo 2 reclutados, 41 cumplieron con los criterios de inclusión. La muestra fue dividida en dos grupos homogéneos. A ambos grupos se les aplicó una batería de tests cognitivos y extracciones de sangre para medir marcadores inflamatorios y metabólicos antes y después del programa de ejercicio.  Resultados:  en el grupo de intervención, la mejoría cognitiva y calidad de vida estuvieron relacionadas al descenso significativo de los marcadores de inflamación IL-6 y ferritina, así como de marcadores metabólicos. En contraste, el grupo control no mostró ninguna mejoría.  Conclusiones:  una aplicación precoz y periódica del programa de 20 semanas de ejercicio controlado u otro similar en el tratamiento de los diabéticos mellitus tipo 2 asistidos por nuestro SNIS puede contribuir en la prevención del deterioro cognitivo y la enfermedad de Alzheimer.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Diabetes mellitus type 2 is a disorder caused by insulin resistance in 90 per cent of cases and determines risk of vascular dementia and Alzheimer&#8217;s disease. Low grade chronic and systemic inflammation determines a loss in insulin sensitivity in the brain and cognitive deterioration. The study aimed to assess the impact of a 20 week exercise program on the cognitive (including quality of life) and inflammatory status in a sample of patients with type 2 diabetes mellitus whose diagnosis is ten years or less, assisted in our national integrated health system.  Method: clinical, open, randomised and controlled study on patients of the primary level of care. 41 out of 168 patients with type 2 diabetes mellitus recruited met the inclusion criteria. The sample was divided into two homogeneous groups. Both groups underwent cognitive tests and blood samples were taken to measure inflammatory and metabolic markers, before and after the exercise program.  Results: cognitive and quality of life improvement were correlated to a significant decrease of inflammation markers: IL-6 and ferritin, as well as of metabolic markers. Unlike this, no improvement was seen in the control group.  Conclusions:  early and regular application of the 20 week controlled exercise program or similar to treat patients with type 2 diabetes mellitus who are followed by our national integrated health system may contribute to preventing cognitive deterioration and Alzheimer&#8217;s disease.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo: A diabetes mellitus tipo 2, em 90% dos casos, é devida à insulina-resistência e é um determinante de risco para demência vascular e doença de Alzheimer. A inflamação sistêmica e crônica, de baixo grau de intensidade determina perda de sensibilidade à insulina no cérebro e deterioro cognitivo. O objetivo deste trabalho foi avaliar o impacto de um programa de exercícios de vinte semanas sobre o status cognitivo (incluindo qualidade de vida) e inflamatório em uma amostra de diabéticos mellitus tipo 2 cujo diagnóstico foi realizado em um período menor ou igual a dez anos, atendidos no sistema nacional integrado de salud.  Método:  o estudio foi clínico, aberto, randomizado e controlado com pacientes atendidos no primeiro nível de atenção. Dos168 pacientes diabéticos tipo 2 recrutados, 41 cumpriam com os critérios de inclusão. A amostra foi dividida em dois grupos homogêneos. Ambos os grupos foram submetidos a uma bateria de testes cognitivos e coleta de sangue para medir marcadores inflamatórios e metabólicos, antes e depois do programa de exercícios.  Resultados:  no grupo de intervenção, a melhoria cognitiva e de qualidade de vida estavam relacionadas a diminuição significativa dos marcadores de inflamação: IL-6 e ferritina, bem como dos marcadores metabólicos. No entanto, o grupo controle não mostrou nenhuma melhoria.  Conclusões:  a aplicação precoce e periódica do programa de vinte semanas de exercícios controlados, ou outro similar, no tratamento dos pacientes diabéticos mellitus tipo 2 atendidos no sistema nacional integrado de saúde (SNIS) pode contribuir para a prevenção do deterioro cognitivo e da doença de Alzheimer.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Diabetes mellitus tipo 2]]></kwd>
<kwd lng="es"><![CDATA[Calidad de vida]]></kwd>
<kwd lng="es"><![CDATA[Ejercicio]]></kwd>
<kwd lng="en"><![CDATA[Type 2 diabetes mellitus]]></kwd>
<kwd lng="en"><![CDATA[Quality of life]]></kwd>
<kwd lng="en"><![CDATA[Exercise]]></kwd>
<kwd lng="pt"><![CDATA[Diabetes mellitus tipo 2]]></kwd>
<kwd lng="pt"><![CDATA[Qualidade de vida]]></kwd>
<kwd lng="pt"><![CDATA[Exercício]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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