Abstract

SERVIOLI, Luisa Fernanda. Adult IgA vasculitis: Literature review. Rev. Urug. Med. Int. [online]. 2024, vol.9, e201.  Epub Dec 01, 2024. ISSN 2393-6797.  https://doi.org/10.26445/09.01.15.

The following literature review focuses on the most relevant and controversial aspects of this entity in terms of clinical presentation, pathogenesis, diagnosis and therapeutic approach. Although IgA vasculitis is the most common in pediatrics, it can occur in adults with a different clinical presentation and a more serious prognosis than in children, including progression to end-stage renal disease. In adults, there are no universally accepted diagnostic criteria and treatment is controversial, given the absence of randomized controlled studies to support it. There have been recent advances in the understanding of environmental and genetic factors, in the abnormalities of innate and acquired immunity and in the role of galactose-deficient IgA1 immune complexes.

Keywords : IgA vasculitis; glomerulonephritis; Henöch- Schonlein purpura; Immune Complex vasculitis; vascular purpura.

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