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Revista Uruguaya de Medicina Interna

On-line version ISSN 2393-6797


VALDIVIESO, Carlos Guamán et al. Use of NT-proBNP in the outpatient follow-up of heart failure patients with reduced left ventricular ejection fraction in a multidisciplinary heart failure unit. Rev. Urug. Med. Int. [online]. 2023, vol.8, n.1, pp.26-37.  Epub Mar 01, 2023. ISSN 2393-6797.


Heart failure (HF) is a prevalent clinical syndrome worldwide, which benefits from a multidisciplinary approach, but its outpatient follow-up remains a challenge. The diagnostic and prognostic utility of NT-proBNP is supported by current evidence, but its use in monitoring has not yet been defined. The present study sought to determine whether the variation over time in the value of NT-proBNP was related to changes in the pharmacological treatment of outpatients with HF and reduced left ventricular ejection fraction (LVEF ≤ 40%) in a multidisciplinary heart failure unit. (MHFU).


Retrospective cohort study of patients, who met the inclusion criteria: 2 or more quantifications of NT-proBNP in 12 months and a minimum follow-up of 2 years between 2013 and 2017.


Of 566 members of the MHFU active cohort, 107 met the inclusion criteria; most men (58%), median age 63 years (Q1;Q3: 55.9;71.2), the main comorbidity was arterial hypertension (71%). The etiology of HF was non-ischemic in 56% of the population, and 50% had a functional class - NYHA I. Median baseline NT-proBNP was 698 pg/ml (Q1;Q3: (218;1564), with median baseline LVEF of 30% (Q1;Q3: 27;40). In 55% of the patients, the variation in the NT-proBNP value during follow-up was related to changes in pharmacological treatment.


In half of the population of our cohort, it was shown that NT-proBNP values were related to changes in pharmacological treatment, regardless of the clinical situation.

Keywords : heart failure; multidisciplinary unit; natriuretic peptides; NT-ProBNP.

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