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Revista Uruguaya de Medicina Interna

Print version ISSN 2393-6797On-line version ISSN 2393-6797


DIAZ CUNA, Carolina et al. Multicentric descriptive study of interstitial lung disease associated with autoimmune diseases in health centers in Montevideo, Uruguay. Rev. Urug. Med. Int. [online]. 2018, vol.3, n.3, pp.12-19. ISSN 2393-6797.


The Interstitial Lung Disease (ILD) is a common manifestation from Connective Tisuue Disease (CTD). Objectives: Describe the characteristics of a population with ILD related to CTD in different hospitals of Montevideo. Analize the clinic manifestations, imagenologic pattern and severity of respiratory function evaluated by spirometry.


Retrospective-descriptive of historical study of cohort, between 2008 december and december 2017.


59 patients were enrolled, female 88%, mean age 61.The first symptom in diagnosis was dyspnea. The CTD identified were: Rheumatoid Arthritis (AR) 28%, Sclerodermia (SL) 22%, Mixed-CTD 7%. Debut of ILD before CTD 9%. The 47% of de patients have ILD in the first year of de diagnosis. The imagenologic pattern were: non specific interstitial pneumonia (NSIP) 65%, usual interstitial pneumonia (UIP) 27%, organizing pneumonia 5%, lymphocytic interstitial pneumonia (LIP) 1%. The most common illness in UIP pattern was AR, in NINE was SL. Forced vital capacity (FVC) media was 80%, DLCO media 71%, SL predominate in patients with FVC and DLCO less than 50%.


AR and SL were the most common ILD. Almost half of the patients have ILD in the first year of the diagnosis, the NSIP pattern was the most frequent. UIP was most prevalent in AR and NSIP in SL.

Keywords : Autoimmune disease; connective tissue disease; Interstitial lung disease.

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