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Revista Uruguaya de Medicina Interna

Print version ISSN 2393-6797On-line version ISSN 2393-6797


SILVARINO, Ricardo; GADOLA, Liliana  and  RIOS, Pablo. Obesity and Chronic Kidney Disease. Rev. Urug. Med. Int. [online]. 2017, vol.2, n.3, pp.3-23. ISSN 2393-6797.

Obesity and being overweight are a pandemic. More than half of adults in Latin America are overweight and one in four are obese. In Uruguay, the situation is also worrying. One in two adults is overweight and one in five is obese. Overweight and obesity are linked to the development and progression of chronic kidney disease. This is a direct consequence of obesity through mechanical factors such as hyperfiltration or increased cavitary pressures, or through multiple endocrine and inflammatory mediators regulated by adipose tissue. Indirectly obesity is linked to the development of risk factors for kidney disease such as diabetes mellitus, hypertension, hyperuricemia and non-alcoholic fatty liver. Finally, some pathologies such as nephrolithiasis and the development of neoplasias are more frequent in the scenario of overweight and obesity, and are linked to the development of renal disease. Measures leading to weight loss and the incorporation of healthy habits have been linked to a reduction in the prevalence and progression of renal disease, as well as to an improvement in markers of renal injury such as proteinuria. Inhibition of the renin-angiotensin-aldosterone axis is another effective measure to decrease the progression of renal disease in this population.

Keywords : Obesity; Overweight; Chronic Renal Disease.

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