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Revista Uruguaya de Medicina Interna

Print version ISSN 2393-6797On-line version ISSN 2393-6797


URBAN, Luis et al. Study of sporadic ataxias of adult onset in Hospital de Clínicas de Montevideo - Uruguay. Rev. Urug. Med. Int. [online]. 2017, vol.2, n.2, pp.43-51. ISSN 2393-6797.


Etiological diagnosis of Sporadic Ataxia of Adult Onset (SAAO) is a clinical challenge because its possible causes are multiple. There are no studies of SAAO in our country.


To describe the clinical, imaging and etiological characteristics of patients with SAAO.


Prospective observational study of patients with SAAO who consulted at Hospital de Clínicas de Montevideo from April 2010 to March 2014. A protocolized clinical-paraclinical evaluation was performed to reach the etiological diagnosis. Results: Thirty-six patients were included. In 20 of them an acquired definite etiology was demonstrated. The most frequent were alcoholic and paraneoplastic cerebellar degeneration . The majority of cases in which a treatment of this etiology was instituted resulted in a cessation of the progression or improvement of symptoms. Discussion and Conclusions: The protocolized study of patients with SAAO achieves the etiological diagnosis in more than 50% of the cases. Still, 44% of patients remained without proven etiology, mainly due to the inability to access genetic studies. The factors that are most associated with finding a proven acquired etiology were: rapid progression, pure vermis syndrome and frank asymmetry of symptoms.

Keywords : Ataxia; Sporadic Ataxia of Adult Onset; Cerebellar Degeneration..

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