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Anales de la Facultad de Medicina
On-line version ISSN 2301-1254
Abstract
PEREZ PEREZ, Natalia et al. Prevalence of HPV genotypes in cervical high risk intraepithelial lesions and cervical cancer in the population of Hospital de Clínicas. Montevideo-Uruguay. Anfamed [online]. 2020, vol.7, n.2, e202. Epub Dec 01, 2020. ISSN 2301-1254. https://doi.org/10.25184/anfamed2020v7n2a10.
Cervical Cancer (CC) is a public health problem worldwide. Its indisputable association with the Human Papilloma Virus (HPV) makes its study necessary.
The objective of this work is to know the prevalence of the different HPV genotypes, in pre-invasive high-grade malignant lesions (HSIL) and / or cervical cancer.
Material and Methods:
All women who were referred to Low genital tract service in the Hospital de Clinicas between January 2011 and December 2012, for a PAP suspected of injury and in which HSIL or cervical cancer was later confirmed were typified. Data on age, type of lesion and genotyping were collected. The viral DNA extraction was carried out from cervico-vaginal samples preserved in commercial transport medium (Sacace) using the QIAamp DNA Mini Kit (QIAGEN). 14 high-risk genotypes were searched.
Results:
75 patients were typified, 19 with CCU and 56 with HSIL. HPV 16 was the most prevalent in 61.5% for single infections and almost 100% for multiple infections and 60% for all lesions, followed in prevalence by HPV 31,33 and 45. The HPV 18 was very rare.
Conclusions:
In this sample, the prevalence of HPV 16 is in accordance with national publications, being the most frequent. HPV 18 has a very low prevalence, being 2 cases in 75, always in multiple infections.
Keywords : Human Papillomavirus (HPV); genotype; high-grade cervical intraepitelial lesions; cervical cancer..
