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Anales de la Facultad de Medicina

On-line version ISSN 2301-1254

Abstract

CAMEJO, Natalia et al. Characteristics of male breast cancer in a Uruguayan population. Anfamed [online]. 2018, vol.5, n.1, pp.46-67. ISSN 2301-1254.  http://dx.doi.org/10.25184/anfamed2018v5n1a7.

Breast cancer (BC) in men (MBC) is an uncommon clinical entity. Even though it shares some similarities with female BC, it has a distinctive profile. The objective of this study was to identify the characteristics of MBC and learn how it is managed in our setting.

Materials and methods: retrospective study including patients diagnosed with MBC in three centers in Uruguay for a period of 15 years.

Results: 12 patients were enrolled; the median age was 68 years; a third of whom had a family history (FH).

Clinical and pathological characteristics: all of the tumors were ductal carcinomas of histological grade (HG) 2-3, 1/4 were stage (S) I, half (6) were SII, 6 had axillary metastases, 2/3 were estrogen receptor (ER) / progesterone receptor (PR) +. Three biological subtypes were defined: I) HER2- ER/PR+: 2/3 of patients; II) HER2+: 1/6; and III) triple-negative: 1/6. All patients with localized cancer underwent a mastectomy and most were treated with chemotherapy (CHT). All of those who presented with localized, ER/PR+ cancer received adjuvant hormone therapy, with good adherence and tolerance. Two of the eleven patients treated with radical surgery recurred during evolution; the rest remain in follow-up or treatment without evidence of recurrence.

Conclusion: we presented a series of patients with MBC, with a profile similar to the one reported in the literature. Age at presentation was higher than that of female BC, and most were ER/PR +, HER 2-. However, patients in this series presented with breast cancer in the localized stage and high-grade tumors in a higher proportion than is described in the literature.

Keywords : breast neoplasm; ductal carcinoma; male; diagnosis; treatment..

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