Abstract

SILVEIRA, Felipe Martins; PEREIRA-PRADO, Vanesa  and  BOLOGNA-MOLINA, Ronell. Molecular bases of benign odontogenic tumors: a review of the literature in the context of the latest classification of the World Health Organization. Odontoestomatología [online]. 2022, vol.24, n.39, e315.  Epub Aug 01, 2022. ISSN 0797-0374.  https://doi.org/10.22592/ode2022n39e315.

Odontogenic tumors (OTs) are a heterogeneous group of lesions that range from hamartomas to benign or malignant neoplasms. The present study aimed to review the literature regarding the molecular and genetic aspects from some benign OTs. Based on the review of the included studies, it is supported that genetic background may play an important role in the etiology and pathogenesis of OTs. However, the body of evidence on the subject still does not allow to conclude the definitive mechanisms involved in the development and progression of OTs. It is suggested the development of further molecular and genetic studies evaluating significant samples of OTs to establish its etiopathogenesis, facilitate its diagnostic process and enrich the therapeutic approaches.

Keywords : odontogenic tumors; molecular pathology.

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