Abstract

GOMEZ-HERRERA, Zaira et al. Immunohistochemical profile of odontogenic myxoma, with emphasis on microvascular density and tumor aggressiveness markers. Odontoestomatología [online]. 2020, vol.22, n.35, pp.52-61.  Epub June 01, 2020. ISSN 0797-0374.  https://doi.org/10.22592/ode2020n35a7.

In order to elucidate better the biological behavior of the odontogenic myxoma (OM), immunohistochemistry was performed in 31 samples, using markers related to mechanisms of tumor progression (adhesion, angiogenesis, apoptosis, inflammation and cell proliferation). Odontogenic epithelium was detected in four samples with CK19 and CD138, the latter had a low-expression in extracellular matrix (ECM) and a high-expression in tumor cells. The mean microvascular density (MVD) assessed with CD34 and VEGF-A, was 7.51 and 5.35 blood vessels respectively. A high-expression of Orosomucoid-1 and Mast Cell Tryptase was observed in tumor cells and ECM, while Calretinin was completely negative. The previously mentioned immunohistochemical profile, as well as the low expression of Ki-67, Bcl-2 and p53 and the relatively low MVD, suggests that the proliferative, anti-apoptotic and angiogenic activities do not represent the main growing mechanisms of OM, which could be associated to other events, such as immunomodulation and ECM degradation.

Keywords : odontogenic myxoma; immunohistochemistry; tumoral markers; angiogenesis..

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