SciELO - Scientific Electronic Library Online

 
vol.21 número34Efecto del EDTAC y del ácido cítrico sobre la pared dentinaria. Variación del tiempo de exposición y la edad dentariaÍndice de Higiene Oral en los Escolares de 12 años de la Parroquia Checa en el Cantón Cuenca, Provincia del Azuay - Ecuador, 2016. índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Links relacionados

Compartilhar


Odontoestomatología

versão impressa ISSN 0797-0374versão On-line ISSN 1688-9339

Resumo

DAVILA, Lucía et al. Immunoexpression of biomarkers Bax, Bcl-2, CD-138, H3, Ki-67, MCM3 and p53 in oral lichen planus. Odontoestomatología [online]. 2019, vol.21, n.34, pp.16-26.  Epub 01-Dez-2019. ISSN 0797-0374.  https://doi.org/10.22592/ode2019n34a3.

This study aims to establish an association of the expression of specific biomarkers in oral lichen planus to understand its biological behavior. Materials and methods: An immunohistochemistry study was conducted in 40 cases of oral lichen planus against BAX, BCL-2, CD-138, Histone 3, Ki-67, MCM3 and p53 at the Molecular Pathology Area of the School of Dentistry, UDELAR, Uruguay. Results: A greater expression of BAX was detected compared to BCL-2, suggesting a pro‑apoptotic behavior, supported by the absence of p53 expression. MCM3 expression was more sensitive than Ki-67, considering proliferation alterations. CD-138 had a more intense and uniform expression, determining fewer intercellular adhesion alterations. Conclusions The expression of the proteins studied suggests an alteration in proliferative and apoptotic mechanisms, associated with a pathological behavior of the oral mucosa.

Palavras-chave : oral lichen planus; apoptosis; proliferation.

        · resumo em Espanhol     · texto em Espanhol | Inglês     · Inglês ( pdf ) | Espanhol ( pdf )