Abstract

DAVILA, Lucía et al. Immunoexpression of biomarkers Bax, Bcl-2, CD-138, H3, Ki-67, MCM3 and p53 in oral lichen planus. Odontoestomatología [online]. 2019, vol.21, n.34, pp.16-26.  Epub Dec 01, 2019. ISSN 0797-0374.  https://doi.org/10.22592/ode2019n34a3.

This study aims to establish an association of the expression of specific biomarkers in oral lichen planus to understand its biological behavior. Materials and methods: An immunohistochemistry study was conducted in 40 cases of oral lichen planus against BAX, BCL-2, CD-138, Histone 3, Ki-67, MCM3 and p53 at the Molecular Pathology Area of the School of Dentistry, UDELAR, Uruguay. Results: A greater expression of BAX was detected compared to BCL-2, suggesting a pro‑apoptotic behavior, supported by the absence of p53 expression. MCM3 expression was more sensitive than Ki-67, considering proliferation alterations. CD-138 had a more intense and uniform expression, determining fewer intercellular adhesion alterations. Conclusions The expression of the proteins studied suggests an alteration in proliferative and apoptotic mechanisms, associated with a pathological behavior of the oral mucosa.

Keywords : oral lichen planus; apoptosis; proliferation.

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