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versão impressa ISSN 0797-0374versão On-line ISSN 1688-9339


PEREIRA-PRADO, Vanesa et al. Cell proliferation study in human tooth germs. Odontoestomatología [online]. 2018, vol.20, n.32, pp.78-83. ISSN 0797-0374.

The aim of this study was to determine the expression of MCM4-5-6 in human tooth germs in the bell stage.

Materials and methods:

Histological samples were collected from four fetal maxillae placed in paraffin at the block archive of the Histology Department of the School of Dentistry, UdelaR. Sections were made for HE routine technique and for immunohistochemistry technique for MCM4-5-6.


Different regions of the enamel organ showed 100% positivity in the intermediate layer, a variation from 100% to 0% in the inner epithelium from the cervical loop to the incisal area, and 0% in the stellar reticulum as well as the outer epithelium.


The results show and confirm the proliferative action of the different areas of the enamel organ.

Palavras-chave : MCM4; MCM5; MCM6; tooth germ; cell proliferation.

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