Abstract

APELLANIZ, Delmira; PEREIRA-PRADO, Vanesa; TAPIA-REPETTO, Gabriel  and  BOLOGNA-MOLINA, Ronell. MCM2-7 complex: a review. Odontoestomatología [online]. 2018, vol.20, n.32, pp.4-11. ISSN 0797-0374.  https://doi.org/10.22592/ode2018n32a2.

New cells are formed from preexisting cells through an ordered series of events called cell cycle. As the control of this cycle is fundamental for genome integrity, multiple proteins regulate this process. We currently know that the MCM2-7 complex has a major role in DNA replication in the cell cycle, in particular regarding proliferation. The immunohistochemical identification of the proteins in this complex on tissues may be useful, as they could be used as biomarkers and would help us understand one of the biological mechanisms affected in cancer processes.

Our aim is to collect the existing evidence regarding the members of the MCM2-7 complex, since these proteins could be effective biological cell proliferation markers, which would help practitioners make accurate diagnosis, prognosis and future therapeutic targets of lesions that are mainly neoplastic, especially in the oral mucosa.

Keywords : MCM2-7 complex; cell proliferation; tumors.

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