SciELO - Scientific Electronic Library Online

 
vol.18 issue28Bioactive materials in dentin remineralisationFood consumption during the school playtime. Design and validation of a survey instrument author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Related links

Share


Odontoestomatología

Print version ISSN 0797-0374On-line version ISSN 1688-9339

Abstract

PEREIRA PRADO, Vanesa et al. Metalloproteinases (MMPs) of the extracellular matrix in Dentistry. Odontoestomatología [online]. 2016, vol.18, n.28, pp.20-29. ISSN 0797-0374.

Abstract Most body tissues are found in a constant renovation process, modulated by a large number of proteins that induce tissue synthesis and degradation over time. Matrix metalloproteinases (MMPs) are a family of 25 zinc-dependent endopeptidases in charge of the cleavage of the immediate components of the extracellular matrix. Certain MMPs, especially MMP-2 and MMP-9, are related to the development of dental germ as well as odontogenic tumor invasion and proliferation. They are a significant factor in tumor aggressiveness and possible treatments. Moreover, both MMPs participate in the progression of dental caries and apical periodontitis in patients with necrotic pulp. Several periodontal pathogens promote the secretion of both MMP-2 and MMP-9, increasing the destruction of periodontal tissues, which is closely linked to the progression of the disease. High levels of these MMPs are found in patients undergoing orthodontic treatment, not only in the compression side but also on the tension one. This establishes a connection between tooth movement and tissue renovation. This review analyzes MMPs expression and usefulness in different areas of dental science, emphasizing their potential as biomarkers

Keywords : Matrix metalloproteinases; extracellular matrix; dentistry.

        · abstract in Spanish     · text in English | Spanish     · English ( pdf ) | Spanish ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License