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Archivos de Medicina Interna

Print version ISSN 0250-3816On-line version ISSN 1688-423X


HACKEMBRUCH, H. Jochen; PERNA, Abayubá; GAYE, Andrés  and  CAAMANO, José. Lambert Syndrome - Eaton: Clinical and neurophysiological characteristics. Arch. Med Int [online]. 2015, vol.37, n. 3, pp.163-166. ISSN 0250-3816.

Abstract:   Lambert Eaton myasthenic syndrome (LEMS) is an uncommon neuromuscular joint disease, usually infra diagnosed, with characteristic but nonspecific clinical symptoms but very typical neurophysiological findings. In most cases it is a paraneoplastic syndrome although idiopathic  forms also exist. We describe the case of a patient with typical clinical presentation and neurophysiological findings that allowed the diagnosis. The initial screening for hidden malignancy was negative, but the follow up is essential to rule it out given its strong association. The evolution was satisfactory with symptomatic treatment. We discuss the pathophysiology of the disorder, establishing as fundamental fact, the presence of antibodies against presynaptic voltage-dependent calcium channels, which is essential to understand the symptomatic treatment. We review the features that are associated with increased risk of hidden malignancy and propose a follow-up strategy to throw it off early

Keywords : Eaton Lambert; Myasthenic síndrome; Paraneoplastic syndrome.

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