SciELO - Scientific Electronic Library Online

 
vol.37 issue 3 author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • Have no similar articlesSimilars in SciELO

Share


Archivos de Medicina Interna

Print version ISSN 0250-3816On-line version ISSN 1688-423X

Abstract

COSTALES, Diego et al. First experience of everolimus in patients with tuberous sclerosis and subependymal giant cell astrocytoma in Uruguay. Arch. Med Int [online]. 2015, vol.37, n. 3, pp.150-153. ISSN 0250-3816.

Abstract:    Tuber sclerosis complex (TSC) is a multisystemic genetic disease caused by a loss of function of hamartin/tuberin complex. This results in an m-TOR activation with tumor formation, among which is subependymal giant cell astrocytoma (SEGA). Everolimus inhibits m-TOR reducing SEGA size. The objective of this work is to show the first experience of SEGA treatment with everolimus in Uruguay. Case: 6 years old boy with TSC, with normal development and no history of seizures. At the age of 5 he installed intracranial hypertension due to hydrocephalus secondary to a SEGA. With surgery tumor was partially resect, with a 14.3cm3 tumor remnant. Treatment with everolimus was iniciated with a tumor size reduction of 54.5% after the first month of treatment, 65.5% after 3 months and 68.5% after 6 months. He had minor secondary effects (mouth ulcerations and upper respiratory tract infections). Good response in this patient shows evidence of possible use of everolimus as an adjuvant terapy to surgery in SEGA

Keywords : Tuber Sclerosis; Astrocytoma; Everolimus.

        · abstract in Spanish     · text in Spanish

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License