Abstract

MEDICI, Conrado et al. Topiramate for the prevention of migraine: Experience at a Child Neurology Clinic. Arch. Med Int [online]. 2015, vol.37, n. 2, pp.94-97. ISSN 0250-3816.

Migraine is the most frequent primary headache in pediatric population, and incidence increases with age. Treatment includes know precipitating factors, changes in life style, acute headaches treatment and in some cases preventive medications. Topiramate has proven efficacy in preventive treatment. The objective of this work was to assess response and safety of Topiramate for migraine in a pediatric population. We made a prospective study, between 04/01/2008 to 10/31/2013. Topiramate was started in patients with 3 or more headache episodes per month and effectiveness was considered when a 50% or more reduction in episodes occurred. 190 patients consulted in this period. 63.9% had migraine. 48% were treated with Topiramate, being effective in 89.6% of patients. In 2 patients there was no response to treatment and in 4 patients treatment was discontinued due to worsening of headaches or secondary effects that disappeared after treatment discontinuation. In conclusion Topiramate is effective and secure for migraine preventive treatment in pediatric population

Keywords : Headaches; Migraine; Topiramate.