Abstract

PINEIRO, Natalia; PERNA, Abayubá; BALDIZZONI, Marcela  and  CORREA, Fernando. Analysis of a Uruguayan cohort of patients with Glioblastoma treated with radiotherapy and Temozalamide. Arch. Med Int [online]. 2014, vol.36, n. 3, pp.133-136. ISSN 0250-3816.

Objectives: find out the two-year survival of patients diagnosed with Multiform Glioblastoma (MGB) treated with Temozolamide funded by the National Resource Fund (FNR), and evaluate the safety of therapy and prognostic factors. Methodology: cohort of patients with MGB, treated with Temozolamide between May 2009 and December 2011. Data source: database of the FNR. Results: the 81 patients included had a median overall survival of 18 months; 33  of them were still alive at two years. The multivariate analysis found that the patient’s age and functional status were the risk factors for mortality. Eight patients had severe adverse effects. Discussion: Presentation of the first national results related to the combined therapy of MGB. Survival was similar to that reported in the international reference studies and greater than that described for radiation therapy alone. Benefits were greater in young patients presenting with a good functional capacity before starting therapy. The safety of therapy was deemed acceptable.

Keywords : Multiform glioblastoma; Temozolamide.